G553 Prevalence and pattern of prenatal alcohol exposure determined by alcohol biomarkers in newborn blood spot screening cards

Baldwin, A., Jones, J., Jones, M., Plate, C., & Lewis, D. (2015). Retrospective assessment of prenatal alcohol exposure by detection of phosphatidylethanol in stored dried blood spot cards: An objective method for determining prevalence rates of alcohol consumption during pregnancy. The International Journal Of Alcohol And Drug Research, 4(2), 131-137. doi:http://dx.doi.org/10.7895/ijadr.v4i2.209Aims: To analyze the efficacy of screening banked newborn dried blood spots (DBS) for detection of phosphatidylethanol(PEth), a direct alcohol biomarker, with the purpose of performing a retrospective assessment of statewide prevalence rates ofalcohol consumption in late pregnancy that results in risky prenatal alcohol exposure.Design: Residual DBS samples collected for newborn screening and stored by a state department of public health wereexamined for concentrations of PEth. The prevalence of prenatal alcohol exposure, as determined by this direct alcoholbiomarker, was compared to prevalence rates of alcohol consumption during pregnancy that have been derived from multiplestate-based and national studies using maternal self-report surveys.Setting: DBS cards representative of the general newborn population were collected from multiple hospitals across a singlemidwestern state.Participants: Two hundred fifty anonymous newborn DBS collected for routine metabolic screening in a midwestern state wererequested through the Virtual Repository of Dried Blood Spots.Measures: Concentrations of PEth, a highly specific biomarker of alcohol consumption, were analyzed using a liquidchromatography–tandem mass spectrometry method validated by our laboratory.Findings: Of 2 50 D BS e xamined, 4 % w ere p ositive f or PEth ( PEth ≥ 8 n g/ml) which is indicative of exposure to maternalalcohol consumption during the last month of pregnancy.Conclusions: Detection of PEth from newborn DBS cards can identify prenatal alcohol exposure and also be used forretrospective surveillance of alcohol consumption during the last three to four weeks of pregnancy, using specimens that arecollected for routine metabolic screening and stored by many state health departments.

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Complex Trauma and Prenatal Alcohol Exposure: Clinical Implications

Perspectives on School-Based Issues ◽

10.1044/sbi13.2.32 ◽

2012 ◽

Vol 13 (2) ◽

pp. 32-42 ◽

Cited By ~ 8

Author(s):

Yvette D. Hyter

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Child Development ◽

Academic Outcomes ◽

Complex Trauma ◽

Prenatal Alcohol Exposure ◽

Alcohol Exposure ◽

Clinical Implications ◽

Prenatal Alcohol ◽

The Brain

Abstract Complex trauma resulting from chronic maltreatment and prenatal alcohol exposure can significantly affect child development and academic outcomes. Children with histories of maltreatment and those with prenatal alcohol exposure exhibit remarkably similar central nervous system impairments. In this article, I will review the effects of each on the brain and discuss clinical implications for these populations of children.

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Prenatal Alcohol Exposure Tied to Conduct Problems

Ob Gyn News ◽

10.1016/s0029-7437(07)71051-0 ◽

2008 ◽

Vol 43 (1) ◽

pp. 10

Author(s):

MARY ANN MOON

Keyword(s):

Conduct Problems ◽

Prenatal Alcohol Exposure ◽

Alcohol Exposure ◽

Prenatal Alcohol

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Prenatal alcohol exposure and signs of minor neurological dysfunction at preschool age

Developmental Medicine & Child Neurology ◽

10.1017/s0012162200000979 ◽

2000 ◽

Vol 42 (8) ◽

pp. 508-514 ◽

Cited By ~ 15

Author(s):

Béatrice Larroque ◽

Monique Kaminski ◽

Phillipe Dehaene ◽

Damien Subtil ◽

Denis Querleu

Keyword(s):

Prenatal Alcohol Exposure ◽

Alcohol Exposure ◽

Preschool Age ◽

Neurological Dysfunction ◽

Minor Neurological Dysfunction ◽

Prenatal Alcohol

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Impact of Moderate Prenatal Alcohol Exposure on Problem Behaviors in Preschool and School Children

Zeitschrift für Entwicklungspsychologie und Pädagogische Psychologie ◽

10.1026/0049-8637/a000106 ◽

2014 ◽

Vol 46 (2) ◽

pp. 89-100 ◽

Cited By ~ 1

Author(s):

Manuela Pfinder ◽

Stefan Liebig ◽

Reinhold Feldmann

Keyword(s):

Problem Behaviors ◽

Tobacco Smoke ◽

Prenatal Alcohol Exposure ◽

Alcohol Exposure ◽

Smoke Exposure ◽

Low Ses ◽

German Health ◽

Kiggs Study ◽

Strengths And Difficulties ◽

Prenatal Alcohol

Data on the relation between moderate prenatal alcohol exposure (PAE) and behavioral disorders are inconsistent, and this raises new questions. We examined (1) the association between moderate PAE and problem behaviors and (2) whether these associations differed by levels of socioeconomic status (SES), fetal smoke exposure, or exposure to environmental tobacco smoke (ETS). Data were taken from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) study. Parents evaluated children’s behaviors using the Strengths and Difficulties Questionnaire (SDQ). Results showed a slight, but insignificant, increase of problem behaviors in children with moderate PAE. In 3- to 6-year-olds, PAE had a stronger effect on hyperactivity/inattention in combination with fetal smoke exposure (odds ratio = 2.82), than did PAE alone. Effects were not stronger in low-SES children, but they were stronger in children with ETS. We conclude that moderate PAE might have adverse effects on neurodevelopment, with stronger effects in disadvantaged populations. To confirm our preliminary findings, further research should be conducted.

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