scholarly journals MLLrearranged acute lymphoblastic leukaemia presenting as a maxillary sinus mass with a discordant immunophenotypic profile from the bone marrow

2019 ◽  
Vol 12 (2) ◽  
pp. e227400
Author(s):  
Yunzu Michele Wang ◽  
Jun Qin Mo ◽  
Dennis John Kuo ◽  
Victor Wong
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Maxillary Sinus ◽  
Lymphoblastic Leukaemia ◽  
In Situ Hybridisation ◽  
Fluorescence In Situ Hybridisation ◽  
Primary Mass ◽  
B Cell Malignancy ◽  
Cell Malignancy

We describe an unusual case of pre-B lymphoblastic leukaemia presenting with a unilateral maxillary sinus mass in which biopsies of the primary mass and the bone marrow demonstrated conflicting immunophenotyping results. The extramedullary mass was consistent with a precursor B-cell malignancy, while the bone marrow was initially reported as a possible mature B-cell malignancy. The treatments for the two are fundamentally different, which necessitated a delay in the initiation of his chemotherapy until a clear diagnosis was made. Mixed lineage leukaemia gene rearrangement was confirmed by fluorescence in situ hybridisation in both the primary mass and bone marrow, which unified the diagnosis as pre-B acute lymphoblastic leukaemia given the common cytogenetic feature.

CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK

2009 ◽  
Vol 145 (4) ◽  
pp. 491-499 ◽  
Author(s):  
Julius G. Juarez ◽  
Marilyn Thien ◽  
Aileen Dela Pena ◽  
Rana Baraz ◽  
Kenneth F. Bradstock ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia

scholarly journals Preventive Healthcare and Management for Acute Lymphoblastic Leukaemia in Adults: Case Report and Literature Review

Healthcare ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 531
Author(s):  
Wei-Ping Chen ◽  
Wen-Fang Chiang ◽  
Hung-Ming Chen ◽  
Jenq-Shyong Chan ◽  
Po-Jen Hsiao
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Peripheral Blood ◽  
Rare Case ◽  
Early Recognition ◽  
Abdominal Sonography ◽  
Clinical Scenarios ◽  
Consciousness Disturbance

Acute lymphoblastic leukaemia (ALL) is diagnosed by the presence of at least 30% lymphoblasts in the bone marrow or 20% lymphoblasts in peripheral blood. ALL may be aggressive and include the lymph nodes, liver, spleen, central nervous system (CNS), and other organs. Without early recognition and timely treatment, ALL will progress quickly and may have poor prognosis in clinical scenarios. ALL is a rare type of leukaemia in adults but is the most common type in children. Precipitating factors such as environmental radiation or chemical exposure, viral infection, and genetic factors can be associated with ALL. We report a rare case of ALL with symptomatic hypercalcaemia in an adult woman. The patient presented with general weakness, poor appetite, bilateral lower limbs oedema, consciousness disturbance, and lower back pain for 3 weeks. She had a history of cervical cancer and had undergone total hysterectomy, chemotherapy, and radiation therapy. Her serum calcium level was markedly increased, at 14.1 mg/dl at admission. Neck magnetic resonance imaging, abdominal sonography, abdominal computed tomography, and bone marrow examination were performed. Laboratory data, including intact parathyroid hormone (i-PTH), peripheral blood smear, and 25-(OH) D3, were checked. Bone marrow biopsy showed B cell lymphoblastic leukaemia. Chemotherapy was initiated to be administered but was discontinued due to severe sepsis. Finally, the patient died due to septic shock. This was a rare case of B cell ALL in an adult complicated by hypercalcaemic crisis, which could be a life-threatening emergency in clinical practice. Physicians should pay attention to the associated risk factors. Early recognition and appropriate treatment may improve clinical outcomes.

scholarly journals Understanding the reconstitution of the B-cell compartment in bone marrow and blood after treatment for B-cell precursor acute lymphoblastic leukaemia

2017 ◽  
Vol 178 (2) ◽  
pp. 267-278 ◽  
Author(s):  
Prisca M. J. Theunissen ◽  
Anouk van den Branden ◽  
Alita Van Der Sluijs-Gelling ◽  
Valerie De Haas ◽  
Auke Beishuizen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Cell Precursor ◽  
Cell Compartment

scholarly journals Characterization of Overt B-Cell Lymphomas in Patients With Hepatitis C Virus Infection

Blood ◽  
1997 ◽  
Vol 90 (2) ◽  
pp. 776-782 ◽  
Author(s):  
Salvatore De Vita ◽  
Cosimo Sacco ◽  
Domenico Sansonno ◽  
Annunziata Gloghini ◽  
Franco Dammacco ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cell ◽  
Hcv Infection ◽  
Low Grade ◽  
B Cell Malignancy ◽  
Hodgkin's Lymphomas ◽  
Cell Malignancy

Abstract A pathogenetic role of the hepatitis C virus (HCV) has been hypothesized for a subset of B-cell non-Hodgkin's lymphomas (NHLs). However, the preliminary characterization of B-cell NHLs in HCV-infected individuals has been poorly addressed. In the present study, we report detailed information on 35 consecutive patients with overt B-cell NHL of recent onset and HCV infection; all patients referred to a single oncological center in Northeast Italy. Histopathologic evaluation was performed by a single reference hemopathologist, and the link with the two relevant autoimmune diseases predisposing to B-cell NHL and in which HCV has been implied, ie, “essential” mixed cryoglobulinemia (EMC) and Sjögren's syndrome, was investigated. Control groups included 122 consecutive HCV-negative patients with B-cell NHL and 464 consecutive histopathologic cases of B-cell NHL referred to the same center, as well as 127 consecutive patients with HCV infection and without lymphoma referred to a different center in the same geographical area. B-cell NHLs in HCV-infected patients frequently presented at onset (1) an extranodal localization with peculiar target organs of HCV infection (ie, the liver and major salivary glands) being significantly overrepresented; (2) a diffuse large cell histotype without any prior history of low-grade B-cell malignancy or bone marrow involvement; and (3) a weak association with a full-blown predisposing autoimmune disease, although serum autoimmune features were common and cryoglobulins were always present. Therefore, the HCV-related B-cell NHLs in this oncological series presented distinctive features compared with B-cell NHLs in HCV-negative patients, and they differed from bone marrow low-grade NHLs frequently diagnosed in HCV-positive patients with EMC. Such novel information may be relevant for future research aimed at clarifying the possible link between HCV infection, autoimmunity, nonmalignant B-cell lymphoproliferation, and overt B-cell malignancy.

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