scholarly journals Primary clear-cell urothelial carcinoma of urinary bladder: a not-so-clear entity with review of literature

2019 ◽  
Vol 12 (10) ◽  
pp. e231192 ◽  
Author(s):  
Lalit Kumar ◽  
Anubhav Narwal ◽  
Manoj Kumar ◽  
Seema Kaushal
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Urothelial Cancer ◽  
Clear Cell ◽  
Muscularis Propria ◽  
Urinary Bladder Cancer ◽  
Review Of Literature ◽  
Unusual Variant ◽  
Urothelial Tumours

Primary clear-cell urothelial carcinoma (CCUC) is an uncommon type of urothelial cancer with only 16 cases reported in published literature. Due to the rarity of the tumour, its clinical and prognostic values have not been clearly understood. We present one such rare clinical diagnosis in a 60-year- old man who underwent radical cystectomy (RC) with ileal conduit for urinary bladder cancer. Histopathology showed features of high-grade CCUC infiltrating the muscularis propria. Immunohistochemistry revealed diffuse immunopositivity of pan cytokeratin (CK), GATA3, P40, CK7 but was immunonegative for CD10 and vimentin. Our patient expired 4 months after diagnosis. CCUC has recently been included in the WHO 2016 classification of urothelial tumours. Most of the patients present with poor prognosis. Accurate diagnosis and recognition of this unusual variant are essential for better patient management and prognosis. Early RC seems to be the preferred way of management.

scholarly journals Clear cell urothelial carcinoma of the urinary bladder - a rare pathological entity. A case report and a systematic review of the literature

2019 ◽  
Author(s):  
Ioana Mihai ◽  
Sorina Taban ◽  
Alin Cumpanas ◽  
Emilian Gh. Olteanu ◽  
Mihaela Iacob ◽  
...  
Keyword(s):  
Systematic Review ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Clear Cell ◽  
Citation Index ◽  
Urinary Bladder Cancer ◽  
Review Of The Literature ◽  
Cell Variant ◽  
Clear Cell Variant ◽  
Common Histological Type

The most common histological type of urinary bladder cancer is urothelial carcinoma (UC). In contrast, the clear cell variant of urothelial carcinoma (CCUC) is quite a rare neoplasm. In this study, we report a case of an 81-year-old male, presenting with gross hematuria and acute urinary retention, which was subsequently diagnosed with CCUC at our pathology department. Furthermore, we provide a short systematic review of the literature (PubMed, Scopus, Science Citation Index) for this rare histopathological entity and a brief discussion about its morphological and immunohistochemical (IHC) characteristics.

scholarly journals Clear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature

2014 ◽  
Vol 8 (1) ◽  
Author(s):  
Virginia M Knez ◽  
Willis Barrow ◽  
M Scott Lucia ◽  
Shandra Wilson ◽  
Francisco G La Rosa
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Clear Cell ◽  
Review Of The Literature

scholarly journals Squamous Cell Carcinoma of the Urinary Bladder: Clinicopathological and Molecular Update

2021 ◽  
Author(s):  
Sunil Vitthalrao Jagtap ◽  
Swati S Jagtap ◽  
Parneet Kaur ◽  
Snigdha Vartak
Keyword(s):  
Squamous Cell Carcinoma ◽  
Bladder Cancer ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Urinary Bladder Cancer ◽  
Cell Phenotype ◽  
Molecular Features ◽  
Muscle Invasive

Urinary bladder cancer is one of the most prevalent cancers worldwide.Squamous Cell Carcinoma (SCC) is an uncommon subtype of urinary bladder carcinoma.It is a malignant epithelial neoplasm arising in the urinary bladder demonstrating a pure squamous cell phenotype. On histopathology it is considered when tumor is showing pure squamous morphology without any component of conventional urothelial carcinoma. The SCC is a histologically distinct form of cancer. It arises from the uncontrolled multiplication of cells showing particular cytological or tissue architectural characteristics of squamous cell differentiation, such as the presence of keratin, tonofilament bundles or desmosomes. Majority of bladder SCC are high grade, high stage tumors with most cancers having muscle invasion at the time of diagnosis while overall about 80% of bladder cancers are non-muscle invasive bladder cancer at diagnosis.COX-2 is markedly expressed in all SCCs. An increased COX-2 level induces the development of SCC of the bladder affecting many biological features of this tissue including apoptosis, cell adhesion, angiogenesis and invasiveness.TERT promoter mutations, commonly found in conventional urothelial carcinoma, are also highly prevalent in urinary bladder squamous cell carcinoma suggesting a common tumorgenesis and potential utility as a molecular urine-based-screening assay.This review summarizes the current features related to clinical , pathological, and molecular features of SCC of urinary bladder.

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