scholarly journals Synchronous breast and colon cancer: the importance of multidisciplinary team cancer meetings

2019 ◽  
Vol 12 (12) ◽  
pp. e232680
Author(s):  
Hussain Adnan Abdulla ◽  
Raed Almarzooq ◽  
Amal Alrayes
Keyword(s):  
Colon Cancer ◽  
Multidisciplinary Team ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Radical Mastectomy ◽  
Right Hemicolectomy ◽  
Left Breast ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Ascending Colon

A 58-year-old female patient presented with left breast lump. Mammography and ultrasonography were performed, which reported lesions suspicious of malignancy in the left breast and axilla. Core biopsy of the lesions revealed invasive ductal carcinoma with axillary lymph node metastasis. Staging CT scan (thorax, abdomen and pelvis) identified a coexisting neoplasm in the ascending colon. Colonoscopy was performed and the tumour in the ascending colon was biopsied. Histopathological examination revealed adenocarcinoma. In the multidisciplinary team cancer meeting, it was decided to treat the breast cancer first and then the colon cancer, followed by adjuvant chemotherapy. In the first operation, left modified radical mastectomy was performed. Two weeks after her initial operation, the patient underwent laparoscopic right hemicolectomy. Postoperatively, the patient did not develop any complications and was referred to oncology for chemotherapy.

scholarly journals Trastuzumab induced radiation recall dermatitis: an interesting case

2018 ◽  
Vol 7 (12) ◽  
pp. 2465
Author(s):  
Anupama C. ◽  
Anuradha H. V. ◽  
Vinayak V. Maka
Keyword(s):  
Ductal Carcinoma ◽  
Growth Factor Receptor ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Interesting Case ◽  
Axillary Lymph ◽  
Radiation Recall ◽  
Skin Reactions ◽  
Radiation Recall Dermatitis ◽  
Recall Dermatitis

Radiation recall dermatitis (RRD) is the appearance of skin reactions in previously irradiated skin which is triggered by the administration of certain drugs. Surgery, chemotherapy, and radiotherapy are the mainstay of treatment in breast cancer. RRD induced by trastuzumab has been rarely reported in India. This is a case report of a 56-year-old woman presented to the medical oncology outpatient department of our hospital with breast lump, and she was diagnosed to have human epidermal growth factor receptor 2 (HER-2/neu) positive invasive ductal carcinoma of left breast of stage T2N3cM0. She was treated with neoadjuvant chemotherapy, and she underwent modified radical mastectomy with axillary lymph node dissection. The treating oncologist was planned to start on adjuvant chemotherapy with injection trastuzumab for every four weeks, for 15 cycles. Patient received first dose of injection trastuzumab (450 mg) intravenously in the right (contralateral) arm and developed painful, swollen, erythematous blisters, and maculopapular rashes following the sharp linear borders of her previous radiation fields. She was reviewed by the medical oncologist and diagnosed as a rare case of RRD and treated with topical betamethasone cream. Causality assessment for RRD to trastuzumab was done using Naranjo and WHO-UMC scale and found to be in the category of probable and probable/ likely respectively.

scholarly journals A rare case report of incidental solitary uterine metastasis in primary invasive lobular carcinoma of breast

2016 ◽  
Author(s):  
Vivek Gupta ◽  
Amita Mishra ◽  
Namit Kalra ◽  
Bhawna Narula
Keyword(s):  
Rare Case ◽  
Ductal Carcinoma ◽  
Residual Disease ◽  
Histopathological Examination ◽  
Lobular Carcinoma ◽  
Radical Mastectomy ◽  
Left Breast ◽  
Tram Flap ◽  
Metastatic Pattern ◽  
Her Family

Introduction: Infiltrating Lobular carcinoma (ILC) of the breast is second most common cancer of breast next only to Infiltrating ductal carcinoma (IDC). It has a different metastatic pattern as compared to the IDC. Breast cancer is the most frequent primary site which spreads to gynaecologic organs. Case Presentation: A 40 yrs old Iraqi lady presented as a diagnosed case of lobular carcinoma of left breast. She had already undergone a lumpectomy at Iraq a month back and now had come for completion of treatment. On metastatic workup with PETCT scan, we found a multicentric residual disease in the left breast along with some ipsilateral axillary LN with significant uptake. The concurrent CECT done showed a uterine leiomyomam also. As she was strongly hormone receptor positive, had completed her family and was having mennorhagia probably attributable to uterine fibroids. She was offered hysterectomy with B/L salpingo-oophorectomy. She was keen for breast preservation but in view of her multicentricity of disease on the left breast she was counselled for mastectomy with upfront whole breast reconstruction with TRAM flap. She underwent left modified radical mastectomy with hysterectomy with BSO and TRAM flap reconstruction. The histopathological examination revealed a multicentric, multifocal ILC, grade II with heavy nodal involvement including extracapsular extension. The leiomyoma of uterus also showed tumor deposits from lobular carcinoma breast. Conclusion: We report a very rare case of metastatic pattern of carcinoma of breast. On literature review we found that it is common for the lobular carcinomas of breast to metastasise to gynaecologic organs. Uterine corpus is a very rare site of metastasis for extragenital cancers including breast. All the patients of primary lobular carcinoma of breast should be screened for gynaecologic secondaries in the preoperative workup with high degree of suspicion.

scholarly journals Clinical Assessment of 324 Breast Cancer Cases in Two Centers Between the Years of 1992 and 2002

2003 ◽  
Vol 46 (4) ◽  
pp. 195-199
Author(s):  
Ali Borazan ◽  
Hasan Üstün ◽  
Faruk Aksoy ◽  
Celalettin Vatansev ◽  
Zafer Cantürk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Systemic Chemotherapy ◽  
Ductal Carcinoma ◽  
Estrogen Receptor Status ◽  
Left Breast ◽  
Axillary Lymph Node Metastasis ◽  
University Hospital ◽  
Histopathological Diagnosis ◽  
Axillary Lymph

The records of the 324 patients with breast cancer; diagnosed and followed in two different University Hospital between years of January 1992 and January 2002 were reviewed retrospectively. The median age of the patients was 49.0±12.5 years, with the range of 18 and 90 years. The most frequently seen age interval of the patients was 40 and 49 years. The most frequently seen symptom and physical examination finding of the patients were breast mass. Breast cancer was diagnosed in 324 women, 173 in the left breast and 151 in the right breast. At the hospital admission percentages of the patients’ disease stages were as follows: I (2.8 %), IIA (30.0 %), IIB (24.0 %), IIIA (19.8 %), IIIB (11.4) and IV (12.0 %). The most frequently seen histopathological diagnosis was infiltrative ductal carcinoma (84.4 %). Axillary lymph node metastasis was found in 61.7 % of the patients. Primary therapeutic options and percentages were surgical therapy (78.5 %), systemic chemotherapy (17.5 %) and radiotherapy (4 %). Systemic chemotherapy was given to 81.2 % of the patients. From the files, estrogen receptor status was known in 311 and positive in 128 (41.2 %) of them. Tamoxifen was given patients who had positive estrogen receptor. The five-year survival rate of the patients was calculated as 75.9 %.

scholarly journals Synchronous Occurrence of Primary Breast Carcinoma and Primary Colon Adenocarcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Gurkan Yetkin ◽  
Fevzi Celayir ◽  
Ismail Ethem Akgun ◽  
Ramazan Ucak
Keyword(s):  
Adjuvant Chemotherapy ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Colon Adenocarcinoma ◽  
Right Hemicolectomy ◽  
Left Breast ◽  
Lymph Node Biopsy ◽  
Hepatic Flexure ◽  
Breast Invasive Ductal Carcinoma ◽  
Primary Colon

A 65-year-old female patient presented to the emergency clinic with abdominal pain, meteorism, and intermittent rectal bleeding. Colonoscopy was performed, and a hepatic flexure tumor was detected. Histopathological examination of biopsy revealed adenocarcinoma. Thoracoabdominal CT was performed for staging, and a spiculated contour mass was found incidentally on the left breast. Mammography and ultrasonography were performed for the cause of these findings, and suspicious lesions of malignancy were seen in the left breast. Invasive ductal carcinoma was detected in core needle biopsy samples from lesions. In the multidisciplinary council consisting of oncologist, pathologist, radiologist, and general surgery specialist, it was decided to perform breast operation first and then colon operation, followed by adjuvant chemotherapy. In the first operation, left total mastectomy and sentinel lymph node biopsy were performed. One week after her initial operation, the patient underwent right hemicolectomy. After operations, the patient did not develop postoperative complications and was sent to medical oncology department for adjuvant chemotherapy.

scholarly journals Axillary Lymph Node Metastasis of Colon Cancer—Case Report and Literature Review

2014 ◽  
Vol 03 (12) ◽  
pp. 669-673
Author(s):  
Helena Devesa ◽  
Luísa Pereira ◽  
Álvaro Gonçalves ◽  
Telma Brito ◽  
Teresa Almeida ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Literature Review ◽  
Axillary Lymph Node ◽  
Axillary Lymph Node Metastasis ◽  
Cancer Case ◽  
Axillary Lymph ◽  
Node Metastasis

scholarly journals Vertebral hemangioma coincident with metastasis of colon adenocarcinoma

2016 ◽  
Vol 24 (3) ◽  
pp. 506-509 ◽  
Author(s):  
Krzysztof Zapałowicz ◽  
Grażyna Bierzyńska-Macyszyn ◽  
Bartłomiej Stasiów ◽  
Aleksandra Krzan ◽  
Beata Wierzycka ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Vertebral Body ◽  
Spinal Canal ◽  
Cancer Metastasis ◽  
Histopathological Examination ◽  
Colon Adenocarcinoma ◽  
Quadriceps Muscle ◽  
Right Hemicolectomy ◽  
Tissue Mass ◽  
Colon Cancer Metastasis

The authors report on colon cancer metastasis to the L-3 vertebra, which had been previously found to be involved by an asymptomatic hemangioma. A 61-year-old female patient was admitted after onset of lumbar axial pain and weakness of the right quadriceps muscle. Her medical history included colon cancer that had been diagnosed 3 years earlier and was treated via a right hemicolectomy followed by chemotherapy. Presurgical imaging revealed an asymptomatic hemangioma in the L-3 vertebral body. Computed tomography and MRI of the spine were performed after admission and revealed a hemangioma in the L-3 vertebral body as well as a soft-tissue mass protruding from the L-3 vertebral body to the spinal canal. Treatment consisted of vertebroplasty of the hemangioma, left L-3 hemilaminectomy, and removal of the pathological mass from the spinal canal and the L-3 vertebral body. Histopathological examination revealed the presence of colon cancer metastasis and a hemangioma in the same vertebra.

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