scholarly journals Clinical Assessment of 324 Breast Cancer Cases in Two Centers Between the Years of 1992 and 2002

2003 ◽  
Vol 46 (4) ◽  
pp. 195-199
Author(s):  
Ali Borazan ◽  
Hasan Üstün ◽  
Faruk Aksoy ◽  
Celalettin Vatansev ◽  
Zafer Cantürk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Systemic Chemotherapy ◽  
Ductal Carcinoma ◽  
Estrogen Receptor Status ◽  
Left Breast ◽  
Axillary Lymph Node Metastasis ◽  
University Hospital ◽  
Histopathological Diagnosis ◽  
Axillary Lymph

The records of the 324 patients with breast cancer; diagnosed and followed in two different University Hospital between years of January 1992 and January 2002 were reviewed retrospectively. The median age of the patients was 49.0±12.5 years, with the range of 18 and 90 years. The most frequently seen age interval of the patients was 40 and 49 years. The most frequently seen symptom and physical examination finding of the patients were breast mass. Breast cancer was diagnosed in 324 women, 173 in the left breast and 151 in the right breast. At the hospital admission percentages of the patients’ disease stages were as follows: I (2.8 %), IIA (30.0 %), IIB (24.0 %), IIIA (19.8 %), IIIB (11.4) and IV (12.0 %). The most frequently seen histopathological diagnosis was infiltrative ductal carcinoma (84.4 %). Axillary lymph node metastasis was found in 61.7 % of the patients. Primary therapeutic options and percentages were surgical therapy (78.5 %), systemic chemotherapy (17.5 %) and radiotherapy (4 %). Systemic chemotherapy was given to 81.2 % of the patients. From the files, estrogen receptor status was known in 311 and positive in 128 (41.2 %) of them. Tamoxifen was given patients who had positive estrogen receptor. The five-year survival rate of the patients was calculated as 75.9 %.

scholarly journals Synchronous breast and colon cancer: the importance of multidisciplinary team cancer meetings

2019 ◽  
Vol 12 (12) ◽  
pp. e232680
Author(s):  
Hussain Adnan Abdulla ◽  
Raed Almarzooq ◽  
Amal Alrayes
Keyword(s):  
Colon Cancer ◽  
Multidisciplinary Team ◽  
Ductal Carcinoma ◽  
Histopathological Examination ◽  
Radical Mastectomy ◽  
Right Hemicolectomy ◽  
Left Breast ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Ascending Colon

A 58-year-old female patient presented with left breast lump. Mammography and ultrasonography were performed, which reported lesions suspicious of malignancy in the left breast and axilla. Core biopsy of the lesions revealed invasive ductal carcinoma with axillary lymph node metastasis. Staging CT scan (thorax, abdomen and pelvis) identified a coexisting neoplasm in the ascending colon. Colonoscopy was performed and the tumour in the ascending colon was biopsied. Histopathological examination revealed adenocarcinoma. In the multidisciplinary team cancer meeting, it was decided to treat the breast cancer first and then the colon cancer, followed by adjuvant chemotherapy. In the first operation, left modified radical mastectomy was performed. Two weeks after her initial operation, the patient underwent laparoscopic right hemicolectomy. Postoperatively, the patient did not develop any complications and was referred to oncology for chemotherapy.

scholarly journals Impact of Molecular Subtypes of Breast Cancer on Axillary Lymph Node Metastasis: A Tertiary Center Experience

2021 ◽  
pp. 305-312
Author(s):  
Dharmendra Singh ◽  
Soumen Mukherjee
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Axillary Lymph Node ◽  
Molecular Subtypes ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Node Metastasis ◽  
Tertiary Center

Background: Axillary lymph node metastasis (ALNM) is one of the important prognostic factors of breast cancer. The objective of this study was to assess the risk of ALNM in different molecular subtypes determined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (her2neu) of breast cancer. Methods: This retrospective study was conducted on patients who had undergone upfront breast conserving surgery (BCS) or modified radical mastectomy (MRM). Patients were classified as HR (hormone receptor) +/ her2neu- (ER or PR positive and her2neu negative), HR+/her2neu+ (ER or PR positive and her2neu positive), HR-/her2neu- (ER, PR and her2neu negative or triple negative or basal type), and HR-/her2neu+ (ER or PR negative and her2neu positive). The association between clinicopathological variables and ALNM was evaluated in logistic regression analyses. Results: In this study, 476 patients met the inclusion criteria, and had 67.2% ALNM at diagnosis. ALNM was statistically significantly correlated with age ≤ 40 years (p=0.026), tumor grade (p=0.007), pathological tumor size (P<0.001), estrogen receptor (P=0.045), molecular subtypes (P=0.021), LVI (P<0.001), and PNI (P<0.001). Post Hoc test revealed that HR-/her2neu+ subtypes of breast cancer had the highest and HR+/her2neu- had the lowest risk of ALNM.   Conclusion: ALNM may be predicted by molecular subtypes of breast cancer. The risk of ALNM is less in TNBC although it is clinically more aggressive. These findings may play an important role in gauging the individualized axillary management in breast cancer.

Risk factor for axillary lymph node metastases in microinvasive breast cancer.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 17-17
Author(s):  
S. Ahn
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Axillary Lymph Node ◽  
Ductal Carcinoma ◽  
Estrogen Receptor Status ◽  
Axillary Lymph ◽  
Axillary Lymph Node Metastases ◽  
Node Metastases ◽  
Microinvasive Breast Cancer

17 Background: Sentinel lymph node biopsy (SLNB) in patients with ductal carcinoma in situ (DCIS) was controversial. Usually we didn’t SLNB when we performed conserving operation with small sized DCIS. But sometimes we can find DCIS with microinvasive breast cancer (MIC) after operation. Must do reoperation in all patients? We determined the incidence of positive axillary lymph node (ALN) in patients with MIC and the predictive factors of ALN metastases in these patients. Methods: Between July 1989 and December 2008, 9.635 patients had operation on invasive breast cancer in Asan Medical Center. Among these patients 319 patients had MIC. The research conducted on the 293 patients except who didn’t performed axillary lymph node dissection or SLN biopsy. We retrospectively checked clinical and pathologic variables. Results: There were 22 cases of ALN metastases identified in this group of patients (7.5%). Lymphatic invasion (p<0.001) and positive estrogen receptor status (p=0.03) were independent significant predictors of axillary metastases. Conclusions: Microinvasive breast cancer is associated with a low rate of lymph node metastases. Some breast cancer patients with MIC at low likelihood of lymph node metastases may be spared lymph node evaluation.

scholarly journals Carcinoma en Cuirasse from Recurrent Breast Cancer seen on FDG-PET/CT

2015 ◽  
Vol 5 ◽  
pp. 35 ◽  
Author(s):  
Aung Zaw Win ◽  
Carina Mari Aparici
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Ductal Carcinoma ◽  
Recurrent Breast Cancer ◽  
Left Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Pet Ct ◽  
Recurrent Breast ◽  
Fdg Pet Ct

Our patient was a 36-year-old female diagnosed with Grade II ER+/PR−/Her-2 − ductal carcinoma in situ (DCIS) in the left breast. She underwent left lumpectomy and received treatment with tamoxifen and radiotherapy. Three years later, she presented with multiple diffused skin nodules on the chest and upper left arm. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) exam showed widespread metastasis in the chest, upper left arm, left axillary lymph nodes, and left suprascapular muscle. FDG-PET/CT imaging of breast carcinoma en cuirasse is very rare. FDG-PET/CT is useful in detecting recurrent breast cancer.

scholarly journals Lymph Node Involvement and Related Risk Factors in Patients With Breast Cancer Referred for Radiotherapy: A 20-Year Study on 15000 Women

2021 ◽  
Vol 9 (3) ◽  
pp. 212-216
Author(s):  
Fariborz Rousta ◽  
Maryam Dadashzadeh ◽  
Farshad Mahdavi ◽  
Ali Reza Nasseri
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Estrogen Receptor ◽  
Lymph Node ◽  
Estrogen Receptor Status ◽  
Axillary Lymph ◽  
Significance Level ◽  
Receptor Status ◽  
Estrogen Receptor Positivity ◽  
Related Risk

Objectives: Tumor size and axillary lymph node (LN) involvement are used as prognostic markers and a guide for choosing adjuvant therapy. This study aimed to evaluate LN involvement and related risk factors in patients with breast cancer (BC) referred for radiotherapy. Materials and Methods: Using the census sampling method, 15,000 women with BC referring for radiotherapy were enrolled in this retrospective descriptive study performed at Tabriz University of Medical Sciences during 2000-2020. LN involvement and related risk factors were recorded and analyzed using the t test and ANOVA test at a significance level of P<0.05. Results: The prevalence of LN involvement in this study was 25%. The estrogen receptor status and LN involvement were associated with metastasis. The odds ratio of metastasis in patients with a negative estrogen receptor was about twice that of women with estrogen receptor positivity. Finally, the risk of metastasis in patients presenting with LN involvement was eight times higher than that of patients without LN involvement. Conclusion: In general, estrogen receptor status and LN involvement were associated with metastasis in patients with BC. Thus, these factors can be regarded as a guide to start necessary interventions earlier in at-risk patients.

Sign in / Sign up

Export Citation Format

Share Document