Prolonged cholestasis after acute viral hepatitis: successfully treated with oral steroid

Cholestasis is a rare distinct complication of hepatitis A infection. Usually it runs a long indolent course with significant pruritus and malabsorption lasting for few months. A 9-year-old boy presented with yellowish discolouration of eye for 1 month. Liver function test showed conjugated hyperbilirubinaemia. Serology was positive for hepatitis A IgM antibody. Liver biopsy showed features of hepatitis with cholestasis. Child successfully treated with oral steroids.

Download Full-text

Biomarkers to Assess Liver Function in Various Types of Liver Diseases

International Journal of Clinical and Biomedical Research ◽

10.31878/ijcbr.2019.52.06 ◽

2019 ◽

pp. 28-31

Author(s):

Pradeep G ◽

Vikram B ◽

Sharma DVHS

Keyword(s):

Liver Disease ◽

Liver Function ◽

Obstructive Jaundice ◽

Viral Hepatitis ◽

Liver Function Test ◽

Alcoholic Liver Disease ◽

Liver Diseases ◽

Serum Levels ◽

Function Test ◽

Glutamyl Transferase

Background: It is estimated that liver diseases are among the top ten killer diseases in India, causing deaths every year. Besides, there are those who suffered from chronic liver problems needing recurrent hospitalization and prolonged medical attention, which leaves them physically, mentally, emotionally and financially devastated. Methodology: The study included (n=80) various liver disease patients admitted to the General Medicine department and controls (n=20) subjects were having normal health within the age group of 30-55 years. Serum levels of bilirubin, Aspartate Transaminase, Alanine Amino Transferase, Alkaline Phosphatase and Gamma Glutamyl Transferase parameters were studied among the subjects suffering from cirrhosis, alcoholic liver disease, viral hepatitis, obstructive jaundice type of liver diseases. Result: The results of this study showed that the increase in serum levels of Bilirubin, AST, ALT, ALP and GGT in various types of liver diseases i.e Obstructive jaundice, Cirrhosis of the liver, Viral hepatitis, Alcoholic Liver disease when compared with controls. Conclusion: Biochemistry laboratory investigations i.e. Liver Function Test (LFT) are a simple, easy measure of tools which can early diagnose the various types of liver diseases. Keywords: Liver diseases; Liver Bio-markers; Liver Function Test.

Download Full-text

SURGICAL JAUNDICE IN INFANCY

PEDIATRICS ◽

10.1542/peds.15.2.149 ◽

1955 ◽

Vol 15 (2) ◽

pp. 149-155

Author(s):

William B. Kiesewetter ◽

C. Everett Koop ◽

John D. Farquahr

Keyword(s):

Liver Function ◽

Liver Biopsy ◽

Obstructive Jaundice ◽

Liver Function Test ◽

Total Bilirubin ◽

Exploratory Laparotomy ◽

Function Test ◽

Biliary Ducts ◽

Operative Findings ◽

Overall Mortality

Forty cases of surgical jaundice in the newborn and infancy period have been reviewed from which the following conclusions seem justified: 1. The predominant cause is atresia of the biliary ducts, either extrahepatic or intrahepatic. 2. The only liver function test of use in differentiating hepato-cellular jaundice from obstructive jaundice is the total bilirubin which declines or is irregular in the former and rises steadily and uninterruptedly in obstruction. 3. Liver biopsy is of value in confirming operative findings and giving some measure of prognosis based on the amount of hepatic damage. 4. The end results are discouraging, with 10 per cent operability and 68 per cent overall mortality in the whole series of those operated. 5. After medical causes have been eliminated, exploratory laparotomy should be carried out.

Download Full-text