Virilising adrenocortical carcinoma

2021 ◽  
Vol 14 (6) ◽  
pp. e242895
Author(s):  
Diogo Nunes Correia ◽  
Inês Redondo de Carvalho ◽  
Jeenal Assuani Mangi
Keyword(s):  
Adrenocortical Carcinoma ◽  
Median Overall Survival ◽  
Elevated Serum ◽  
Imaging Study ◽  
Palpable Mass ◽  
Hepatic Invasion ◽  
Serum Androgens ◽  
Rare Malignancy ◽  
The Right

Adrenocortical carcinoma (ACC) is a rare malignancy, with an estimated annual incidence of 0.7–2 cases per million and a median overall survival of 3–4 years. Hormone-secreting ACCs represent most cases; of these, only a small minority presents with virilisation alone. Early diagnosis is key to increase the chances of a better outcome. Here, we report a case of a 41-year-old woman who presented with menstrual irregularities, hirsutism and virilising symptoms, associated with abdominal discomfort and constitutional symptoms. On physical examination, there was a palpable mass in the right upper quadrant. Laboratory workup revealed elevated serum androgens. The imaging study showed a 163×110×122 cm right adrenal mass with features consistent with ACC and suggested potential hepatic invasion. Our patient underwent surgical resection, and the histopathological findings confirmed the diagnosis. She was referred to a specialised centre for follow-up and adjuvant therapy.

scholarly journals Functioning Adrenocortical Carcinoma with Extension upto the Right Atrium Producing Cushing's Syndrome

2013 ◽  
Vol 3 ◽  
pp. 32 ◽  
Author(s):  
Santosh Kumar ◽  
Gautam R. Choudhary ◽  
Arawat Pushkarna
Keyword(s):  
Inferior Vena Cava ◽  
Cushing’S Syndrome ◽  
Adrenocortical Carcinoma ◽  
Right Atrium ◽  
Inferior Vena ◽  
Vena Cava ◽  
Cushing's Syndrome ◽  
Curative Therapy ◽  
Rare Malignancy ◽  
The Right

Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Surgery is the only curative therapy available and overall 5-year survival for patients who undergo a complete resection is 32% to 48%. They are known to produce intravascular invasion and into the inferior vena cava (IVC) and in rare cases they may reach the right atrium. We report a case of functioning ACC extending into the inferior vena cava and right atrium in a female with Cushing's syndrome.

scholarly journals Giant adrenocortical carcinoma simulating a liver tumor

2019 ◽  
pp. 1-3
Author(s):  
Aïcha Ben Miled ◽  
Chadli Dziri ◽  
Hichem Jerraya ◽  
Ibtissem Bouasker ◽  
Mohamed Ali ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Adrenocortical Carcinoma ◽  
Adrenal Tumor ◽  
Abdominal Mass ◽  
Percutaneous Biopsy ◽  
Ultrasound Computed Tomography ◽  
Costophrenic Angle ◽  
Histological Factors ◽  
The Right

Adrenocortical carcinoma is a rare malignant tumor which can reach large sizes if it is nonfunctioning. In that situation, it can pose diagnosis dilemmas regarding the origin and the nature of the tumor. We reported a case of non-secreting and large right Adrenocortical carcinoma which arose in the posterior costophrenic angle mimicking a liver tumor. A 45-year-old man presented with a voluminous abdominal mass in the right upper quadrant. The different imaging modalities including ultrasound computed tomography and magnetic resonance imaging were discordant as regards the hepatic or the adrenal origin of the tumor. Percutaneous biopsy allowed to determine the diagnosis of the cortico-adrenal tumor. The patient underwent laparotomy. The tumor which arose from the right adrenal gland was resected. Pathology confirmed the diagnosis of adrenocortical carcinoma with histological factors of poor prognosis. The patient was given Mitotane as adjuvant therapy. After six years of follow-up, a tumor recurrence has been diagnosed.

scholarly journals Right Atrial Diverticulum in an Adult Woman with Left Bundle Branch Block

2020 ◽  
Vol 20 (4) ◽  
pp. e394-396
Author(s):  
Behnam Shakerian ◽  
Mohammad H. Mandegar
Keyword(s):  
Left Bundle Branch Block ◽  
Imaging Study ◽  
Right Atrial ◽  
Magnetic Resonance Imaging Study ◽  
Resonance Imaging ◽  
Bundle Branch Block ◽  
Clinical Presentations ◽  
History Of ◽  
The Right

Right atrial diverticulum is a very rare anomaly. It is an outpouching arising from the right atrial free wall. Clinical presentations vary widely but some cases are associated with supraventricular tachycardia and atrial flutter/fibrillation. The incidence/prevalence of this anomaly is not available because only a few cases have been reported. We report a 38-year-old female patient who presented to the Heart Clinic, Tehran, Iran in 2019 with a history of dyspnea and chest pain. Electrocardiography revealed left bundle branch block. Following a magnetic resonance imaging study, the patient was diagnosed with a right atrial diverticulum. She underwent surgical resection of the diverticulum. The post-operative course was uneventful and no recurrence of the arrhythmia was detected during the six months of follow-up. To the best of the authors’ knowledge, this combination has not been described in the literature. Keywords: Right Atrium; Diverticulum; Left Bundle Branch Block; Case Report; Iran.

scholarly journals Three-Dimensional Computed Tomography Follow-Up on Spontaneous Bone Healing after Excision of Periorbital Dermoid Cyst: A Case Report

2021 ◽  
Vol 17 (3) ◽  
pp. 213-217
Author(s):  
Hannara Park ◽  
Jaemin Seong ◽  
Hyochun Park ◽  
Hyeonjung Yeo
Keyword(s):  
Computed Tomography ◽  
Dermoid Cyst ◽  
Three Dimensional ◽  
Surgical Excision ◽  
Complete Recovery ◽  
Bony Defect ◽  
Palpable Mass ◽  
Nodular Lesions ◽  
The Right

Dermoid cysts are among the most common periorbital and orbital tumors presenting in childhood. Several studies have shown that dermoid cysts may deform adjacent bones; however, few studies have followed the course of bone regeneration after the excision of a cyst. We report a case of a 29-month-old female infant who presented with a palpable mass over her right lateral eyebrow. Ultrasonography findings suggested a dermoid cyst, and computed tomography revealed a 2.1-cm round bony defect in the right zygoma. After surgical excision of the dermoid cyst, we successfully applied fibrin sealant to eliminate the dead space. Pathological findings showed nodular lesions with flat cystic walls containing lamellated keratin and sebaceous glands, supporting the diagnosis of dermoid cyst. At 6 months postoperatively, a follow-up computed tomography scan confirmed complete recovery of the bone defect in the right zygoma.

scholarly journals Adrenocortical Carcinoma Discovered with Point-of-care Ultrasound

2021 ◽  
Vol 5 (4) ◽  
pp. 482-484
Author(s):  
Mark McIntyre ◽  
Michael Prats
Keyword(s):  
Lower Extremity ◽  
Adrenocortical Carcinoma ◽  
Point Of Care ◽  
Cystic Mass ◽  
Obstructive Nephropathy ◽  
Point Of Care Ultrasound ◽  
Lower Extremity Edema ◽  
Important Diagnostic Tool ◽  
Rare Malignancy ◽  
The Right

Case Presentation: A 34-year-old woman presented to the emergency department with bilateral lower extremity edema and shortness of breath. She had been seen by her primary care provider. Lab work and a follow-up with endocrinology had been unrevealing. Using point-of-care ultrasound we identified a cystic mass in the right upper quadrant prompting further imaging. Discussion: Abdominal and pelvic computed tomography confirmed a mass in the right posterior liver, which was later identified as an adrenocortical carcinoma. Ultrasound is an important diagnostic tool in the setting of lower extremity edema and can be used to assess for heart failure, liver failure, obstructive nephropathy, venous thrombosis, and soft tissue infection. In this case, ultrasound helped expedite the diagnosis and treatment of a rare malignancy.

scholarly journals Sinus of Valsalva Aneurysm: A Rare Cause of Dyspnea

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Aiman Smer ◽  
Osama Elsallabi ◽  
Mohamed Ayan ◽  
Haitam Buaisha ◽  
Hamza Rayes ◽  
...  
Keyword(s):  
Incidental Finding ◽  
Clinical Manifestations ◽  
Imaging Study ◽  
Sinus Of Valsalva ◽  
Sinus Of Valsalva Aneurysm ◽  
Bentall Procedure ◽  
Life Threatening ◽  
The Right ◽  
Left Sinus Of Valsalva

Sinus of Valsalva aneurysm (SOVA) is a rare clinical entity. Clinical manifestations can vary from an incidental finding on an imaging study to a life-threatening emergency. We report a case of a 51-year-old female with a large symptomatic left SOVA. Echocardiogram and computed tomography angiography (CTA) of the chest revealed marked dilatation of the left sinus of Valsalva, measuring 7.5 cm. This resulted in superior displacement of the left main coronary artery. Surgical repair of the aneurysm with reimplantation of the right and left coronary arteries was performed in addition to aortic valve replacement (Bentall procedure). The patient had an uneventful postoperative course and remains asymptomatic at the three-month follow-up visit.

scholarly journals A Case Giving Proof of Pathogenesis of Abdominoscrotal Hydrocele: A Case Report

2021 ◽  
Vol 27 (2) ◽  
pp. 91-94
Author(s):  
Hee Jo Yang ◽  
Myoung Won Son ◽  
Doo Sang Kim
Keyword(s):  
Abdominal Cavity ◽  
Surgical Excision ◽  
Cystic Mass ◽  
Palpable Mass ◽  
Lower Quadrant ◽  
Uncommon Condition ◽  
Abdominoscrotal Hydrocele ◽  
The Right ◽  
Right Lower Quadrant

An abdominoscrotal hydrocele (ASH) is an uncommon condition characterized by cystic mass that occupies the scrotum and abdomen. The characteristic aspect is the presence of two hydrocele sacs in the abdominal cavity and the scrotum, and compression of one side causes enlargement of the other side, thereby connecting the two sacs. There are several hypotheses regarding the occurrence of ASH. However, the evidence of the hypotheses is lacking. The patient was a 52-year-old male. During observation of the right inguinoscrotal hydrocele, the patient complained of a palpable mass lesion on the right lower quadrant of the abdomen. Physical examination revealed ASH that occurred with the growth of the inguinoscrotal hydrocele. This was further confirmed by sequential imaging test thereby proposing the verification of cephalad extension of hydrocele. The surgical excision was recommended and inguinal exploration was performed under general anesthesia. No evidence of relapse was observed during the 2-year follow-up period after surgery. The present case proves the cephalad extension of hydrocele among other hypotheses on the etiology of ASH.

scholarly journals Paediatric Nonfunctioning Adrenocortical Carcinoma with Extension up to Right-Side Heart: Cardiac Surgery Approach

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Federica Iezzi ◽  
Andrea Quarti ◽  
Chiara Surace ◽  
Marco Pozzi
Keyword(s):  
Cardiac Surgery ◽  
Adrenal Gland ◽  
Adjuvant Treatment ◽  
Adrenocortical Carcinoma ◽  
Rare Case ◽  
Cardiac Involvement ◽  
Adrenal Carcinoma ◽  
Rare Malignancy ◽  
The Right ◽  
Treatment Prognosis

Adrenocortical carcinoma is a rare malignancy. Due to late diagnosis and no adequate effective adjuvant treatment, prognosis remains poor. Only approximately 30% of these malignancies are confined to the adrenal gland when they are diagnosed, as these tumors tend to be found years after their genesis. Cardiac involvement of adrenal carcinoma is very rare. We report a rare case of a 7-year-old female with right adrenal cortical carcinoma, involving the right-side heart.

scholarly journals Venous thromboembolism in patients with adrenocortical carcinoma after surgery

2020 ◽  
Vol 9 (9) ◽  
pp. 874-881
Author(s):  
Jülide Durmuşoğlu ◽  
Henri J L M Timmers ◽  
Pepijn van Houten ◽  
Hans F Langenhuijsen ◽  
Ad R M M Hermus ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Venous Thromboembolism ◽  
High Risk ◽  
Adrenocortical Carcinoma ◽  
Pulmonary Metastases ◽  
Low Molecular Weight ◽  
Symptomatic Pulmonary Embolism ◽  
Pulmonary Embolisms ◽  
Rare Malignancy

Background: Adrenocortical carcinoma is a rare malignancy with a poor prognosis. We hypothesized that patients with adrenocortical carcinoma are at high risk for venous thromboembolism, given the numerous risk factors such as malignancy, abdominal surgery, immobility and hormonal excess. The aim of this study was to determine retrospectively the incidence of venous thromboembolisms after surgical treatment in patients with adrenocortical carcinoma. Materials and methods: A retrospective study was performed, collecting data from all patients diagnosed with adrenocortical carcinoma from 2003 to 2018 at the Radboud University Medical Centre, The Netherlands. Results: In 34 patients, eight postoperative venous thromboembolisms, all pulmonary embolisms, were diagnosed in the first 6 months after adrenalectomy (23.5%). In addition, one patient developed pulmonary embolism just prior to surgery and one patient 7 years after surgery. Five of the eight patients with postoperative venous thromboembolisms presented with symptomatic pulmonary embolism whereas the other three pulmonary embolisms were incidentally found on regular follow up CT scans. Seven of the eight venous thromboembolisms occurred within 10 weeks after surgery. Seven of the eight patients had advanced stage adrenocortical carcinoma and four patients already received low-molecular weight heparin during the development of the venous thromboembolism. There was one case of fatal pulmonary embolism in a patient with a cortisol producing tumor with pulmonary metastases, despite the use of a therapeutic dose thromboprophylaxis. Conclusion: Patients with adrenocortical carcinoma are at high risk of developing postoperative venous thromboembolisms. Prolonged postoperative thromboprophylaxis could be considered in these patients.

CASE REPORT: SURGICAL MANAGEMENT OF LUMBAR COMPRESSION FRACTURE

2019 ◽  
Vol 1 (4) ◽  
Author(s):  
Yustinus Robby Budiman Gondowardojo ◽  
Tjokorda Gde Bagus Mahadewa
Keyword(s):  
Spinal Cord ◽  
Left Lung ◽  
Lumbar Vertebrae ◽  
Compression Fracture ◽  
High Mobility ◽  
Early Mobilization ◽  
Cord Injury ◽  
Cardiothoracic Surgeon ◽  
The Right

The lumbar vertebrae are the most common site for fracture incident because of its high mobility. The spinal cord injury usually happened as a result of a direct traumatic blow to the spine causing fractured and compressed spinal cord. A 38-year-old man presented with lumbar spine’s compression fracture at L2 level. In this patient, decompression laminectomy, stabilization, and fusion were done by posterior approach. The operation was successful, according to the X-Ray and patient’s early mobilization. Pneumothorax of the right lung and pleural effusion of the left lung occurred in this patient, so consultation was made to a cardiothoracic surgeon. Chest tube and WSD insertion were performed to treat the comorbidities. Although the patient had multiple trauma that threat a patient’s life, the management was done quickly, so the problems could be solved thus saving the patient’s life. After two months follow up, the patient could already walk and do daily activities independently.

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