Recurrent severe respiratory infections with low CRP secondary to autoimmune IL-6 deficiency

2021 ◽  
Vol 14 (6) ◽  
pp. e243334
Author(s):  
Alexander Hackney ◽  
Sunil James ◽  
Surendra Karanam
Keyword(s):  
Treatment Response ◽  
Clinical Presentation ◽  
Respiratory Infections ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory Protein ◽  
Severe Infections

C reactive protein (CRP) is an inflammatory protein that is often used in conjunction with the clinical presentation of a patient to help with quantifying infection severity and measuring treatment response. We report the case of a patient who presented with severe pneumonias but had a suboptimal CRP response, later diagnosed as having an underlying immunodeficiency. This case exemplifies the need to consider immunodeficiency as an underlying pathophysiological cause in patients presenting with complicated and severe infections.

Nasopharyngeal Carriage of Invasive Pneumococcal Serotypes During Childhood Community-Acquired Alveolar Pneumonia Is Associated With Specific Clinical Presentation

2019 ◽  
Author(s):  
Yaniv Faingelernt ◽  
Ron Dagan ◽  
Noga Givon-Lavi ◽  
Shalom Ben-Shimol ◽  
Jacob Bar-Ziv ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Pediatric Emergency ◽  
Nasopharyngeal Carriage ◽  
Pneumococcal Serotypes ◽  
C Reactive Protein ◽  
Blood Cell Count ◽  
Invasive Potential ◽  
Viral Detection ◽  
Reactive Protein ◽  
Lower Oxygen

Abstract Background Streptococcus pneumoniae (Pnc) serotypes differ in invasive potential. We examined whether community-acquired alveolar pneumonia (CAAP) in children carrying commonly recognized pneumonia invasive pneumococcal serotypes ([PnIST] 1, 5, 7F, 14, and 19A) differs from CAAP in children carrying less invasive serotypes (non-PnIST) or no Pnc (Pnc-neg). Methods Children <5 years, visiting the only regional Pediatric Emergency Room, with radiologically proven CAAP were enrolled. Nasopharyngeal cultures were processed for pneumococcal isolation and serotyping. Clinical and demographic characteristics were recorded. The study was conducted before pneumococcal conjugate vaccine implementation in Israel. Results A total of 1423 CAAP episodes were recorded: PnIST, 300 (21.1%); non-PnIST, 591 (41.5%); and Pnc-neg, 532 (37.4%). After adjustment for age, ethnicity, seasonality, and previous antibiotics, the following variables were positively associated with PnIST carriage compared with both groups: temperature ≥39°C, peripheral white blood cell count ≥20 000/mm3, C-reactive protein ≥70.0 mg/L, and serum sodium <135 mEq/L. Lower oxygen saturation, viral detection, and comorbidities were negatively associated with Pn-IST carriage (odds ratios, <1.0). Differences between non-PnIST carriers and Pnc-neg groups were smaller or nonsignificant. Conclusions Young children with CAAP carrying common PnIST had a lower proportion of comorbidities, hypoxemia, and viral detection and had more intense systemic inflammatory response than those carrying non-PnIST or not carrying Pnc.

Concentrations of tumor-associated trypsin inhibitor and C-reactive protein in serum in acute pelvic inflammatory disease.

1989 ◽  
Vol 35 (5) ◽  
pp. 869-871 ◽  
Author(s):  
J Paavonen ◽  
M Lehtinen ◽  
M Lehto ◽  
S Laine ◽  
R Aine ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Acute Phase ◽  
Trypsin Inhibitor ◽  
Inflammatory Disease ◽  
Acute Phase Proteins ◽  
Endometrial Biopsy ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Acute Pelvic Inflammatory Disease ◽  
Severe Infections

Abstract We measured tumor-associated trypsin inhibitor (TATI) and C-reactive protein (CRP) in serum of 29 patients with proven pelvic inflammatory disease (PID). TATI values were increased in seven (24%), paralleling increases in CRP. TATI was increased by about 3.5-fold in seven of eight patients with CRP concentrations greater than 90 mg/L, but in none of 21 patients with CRP concentrations less than 90 mg/L. TATI concentration and severity of PID as determined by laparoscopy or endometrial biopsy were not correlated. These results suggest that, in severe infections, regulation of TATI synthesis resembles that of acute-phase proteins.

The Kidney, Liver, Index surgery and C reactive protein score is a predictor of treatment response in acute prosthetic joint infection

2017 ◽  
Vol 42 (1) ◽  
pp. 33-38 ◽  
Author(s):  
C Jiménez-Garrido ◽  
J M Gómez-Palomo ◽  
I Rodriguez-Delourme ◽  
F J Durán-Garrido ◽  
E Nuño-Álvarez ◽  
...  
Keyword(s):  
Treatment Response ◽  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Liver Index ◽  
Prosthetic Joint ◽  
Kidney Liver

scholarly journals Biomarkers for Sepsis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Cesar Henriquez-Camacho ◽  
Juan Losa
Keyword(s):  
Antibacterial Therapy ◽  
Respiratory Infections ◽  
Bloodstream Infections ◽  
Signs And Symptoms ◽  
Antibiotic Consumption ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory Conditions ◽  
Empirical Antibacterial Therapy ◽  
New Biomarkers

Bloodstream infections are a major concern because of high levels of antibiotic consumption and of the increasing prevalence of antimicrobial resistance. Bacteraemia is identified in a small percentage of patients with signs and symptoms of sepsis. Biomarkers are widely used in clinical practice and they are useful for monitoring the infectious process. Procalcitonin (PCT) and C-reactive protein (CRP) have been most widely used, but even these have limited abilities to distinguish sepsis from other inflammatory conditions or to predict outcome. PCT has been used to guide empirical antibacterial therapy in patients with respiratory infections and help to determine if antibacterial therapy can be stopped. New biomarkers such as those in this review will discuss the major types of biomarkers of bloodstream infections/sepsis, including soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), soluble urokinase-type plasminogen receptor (suPAR), proadrenomedullin (ProADM), and presepsin.

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