The BMJ Awards 2021: “Landmark” study on dexamethasone wins paper of the year

BMJ ◽  
2021 ◽  
pp. n2389
Author(s):  
Matthew Limb
Keyword(s):  
Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1869
Author(s):  
A K M Mashud Alam ◽  
Donovan Jenks ◽  
George A. Kraus ◽  
Chunhui Xiang

Organophosphate (OP) compounds, a family of highly hazardous chemical compounds included in nerve agents and pesticides, have been linked to more than 250,000 annual deaths connected to various chronic diseases. However, a solid-state sensing system that is able to be integrated into a clothing system is rare in the literature. This study aims to develop a nanofiber-based solid-state polymeric material as a soft sensor to detect OP compounds present in the environment. Esters of polydiacetylene were synthesized and incorporated into a cellulose acetate nanocomposite fibrous assembly developed with an electrospinning technique, which was then hydrolyzed to generate more hydroxyl groups for OP binding. Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), Instron® tensile tester, contact angle analyzer, and UV–Vis spectroscopy were employed for characterizations. Upon hydrolysis, polydiacetylene esters in the cellulosic fiber matrix were found unaffected by hydrolysis treatment, which made the composites suitable for OP sensing. Furthermore, the nanofibrous (NF) composites exhibited tensile properties suitable to be used as a textile material. Finally, the NF composites exhibited colorimetric sensing of OP, which is visible to the naked eye. This research is a landmark study toward the development of OP sensing in a protective clothing system.


2016 ◽  
Vol 113 (29) ◽  
pp. 7970-7977 ◽  
Author(s):  
Brett R. Riddle

Deciphering the geographic context of diversification and distributional dynamics in continental biotas has long been an interest of biogeographers, ecologists, and evolutionary biologists. Thirty years ago, the approach now known as comparative phylogeography was introduced in a landmark study of a continental biota. Here, I use a set of 455 studies to explore the current scope of continental comparative phylogeography, including geographic, conceptual, temporal, ecological, and genomic attributes. Geographically, studies are more frequent in the northern hemisphere, but the south is catching up. Most studies focus on a Quaternary timeframe, but the Neogene is well represented. As such, explanations for geographic structure and history include geological and climatic events in Earth history, and responses include vicariance, dispersal, and range contraction-expansion into and out of refugia. Focal taxa are biased toward terrestrial or semiterrestrial vertebrates, although plants and invertebrates are well represented in some regions. The use of various kinds of nuclear DNA markers is increasing, as are multiple locus studies, but use of organelle DNA is not decreasing. Species distribution models are not yet widely incorporated into studies. In the future, continental comparative phylogeographers will continue to contribute to erosion of the simple vicariance vs. dispersal paradigm, including exposure of the widespread nature of temporal pseudocongruence and its implications for models of diversification; provide new templates for addressing a variety of ecological and evolutionary traits; and develop closer working relationships with earth scientists and biologists in a variety of disciplines.


2016 ◽  
Vol 21 (3) ◽  
pp. 531-537 ◽  
Author(s):  
Hiroaki Ogata ◽  
◽  
Masafumi Fukagawa ◽  
Hideki Hirakata ◽  
Hideaki Kaneda ◽  
...  

2011 ◽  
Vol 19 (4) ◽  
pp. 563-577 ◽  
Author(s):  
Luke McKernan

The title of Allen Guttmann's landmark study of sports history,From Ritual to Record, captures the way cinematic treatments of the Olympic Games, Europe's most resonant sporting invention, developed in the early twentieth century. Projected film and the modern Olympic Games began in the same year, 1896, and the way the two phenomena have grown together demonstrates a progression from formality and ritual to an ever-increasing emphasis on individual, nation and achievement. This transition from ritual to record is demonstrated by two Olympic films from the European Games of Paris 1924 and Amsterdam 1928,Les Jeux Olympiques Paris 1924andDe Olympische Spelen. These cinematic records are not only documentary records of the events they portray, but are an important reminder that modern sports are witnessed by most not as stadium spectators but as viewers – in the case of the 1924 and 1928 films, as members of a cinema audience. The film record is essential to our understanding of the popularisation of modern sports, while through their contrary impulses to document and to idealise (particularly through the use of slow-motion photography), the two films demonstrate what is meaningful about Olympic sport.


2005 ◽  
Vol 32 (2) ◽  
pp. 185-203
Author(s):  
S. C. Mishra
Keyword(s):  

2020 ◽  
Author(s):  
Nikhil Goyal ◽  
Dustin Moraczewski ◽  
Peter Bandettini ◽  
Emily S. Finn ◽  
Adam Thomas

AbstractUnderstanding brain functionality and predicting human behavior based on functional brain activity is a major goal of neuroscience. Numerous studies have been conducted to investigate the relationship between functional brain activity and attention, subject characteristics, autism, psychiatric disorders, and more. By modeling brain activity data as networks, researchers can leverage the mathematical tools of graph and network theory to probe these relationships. In their landmark study, Smith et al. (2015) analyzed the relationship of young adult connectomes and subject measures, using data from the Human Connectome Project (HCP). Using canonical correlation analysis (CCA), Smith et al. found that there was a single prominent CCA mode which explained a statistically significant percentage of the observed variance in connectomes and subject measures. They also found a strong positive correlation of 0.87 between the primary CCA mode connectome and subject measure weights. In this study, we computationally replicate the findings of the original study in both the HCP 500 and HCP 1200 subject releases. The exact computational replication in the HCP 500 dataset was a success, validating our analysis pipeline for extension studies. The extended replication in the larger HCP 1200 dataset was partially successful and demonstrated a dominant primary mode.


Contexts ◽  
2021 ◽  
Vol 20 (4) ◽  
pp. 69-71
Author(s):  
Cierra Raine Sorin

This book review explores Sexual Citizens: A Landmark Study of Sex, Power, and Assault on Campus by Jennifer S. Hirsch and Shamus Khan, and describes the complicated nature of sexual experiences as an undergraduate.


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