Flash glucose monitoring improves glycemia in higher risk patients: a longitudinal, observational study under real-life settings

ObjectiveTo assess the role of flash glucose monitoring in early and late changes in glycemic markers under real-life conditions.Research design and methodsDeidentified glucose results from 6802 flash glucose monitors were analyzed after dividing into high, medium and low-risk groups based on tertiles of time spent in hypoglycemia (min/day <70 mg/dL) or hyperglycemia (hours/day >240 mg/dL). Groups were further subdivided into tertiles of glucose scanning frequency and glycemic measures analyzed in the first 14 days and over 6 months.ResultsImprovement in dysglycemia mainly occurred in the first month of device use. Comparing first and last 14 study days, high-hyperglycemic-risk individuals showed reduced time >240 mg/dL (mean±SEM) from 6.07±0.06 to 5.73±0.09 hours/day (p<0.0001). High-frequency scanners showed 0.82 hours/day reduction in hyperglycemia (p<0.0001) whereas low-frequency scanners failed to demonstrate a benefit. High-hypoglycemic-risk individuals showed reduction in time ≤54 mg/dL from 90±1 to 69±2 min/day (p<0.0001) comparing first and last 14 study days. This reduction was evident in both low and high-frequency scanners but with reduced hyperglycemic exposure in the latter group.ConclusionsUnder real-world conditions, flash monitoring is associated with rapid and sustained reduction in dysglycemia with high-frequency scanners demonstrating more significant reduction in hyperglycemia.

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Frequency of Flash Glucose Monitoring Scans and Hemoglobin A1c in Real Life

Diabetes ◽

10.2337/db18-898-p ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 898-P

Author(s):

ANDREA LAURENZI ◽

AMELIA CARETTO ◽

MARILUCE BARRASSO ◽

BOLLA ANDREA MARIO ◽

CHIARA MOLINARI ◽

...

Keyword(s):

Hemoglobin A1c ◽

Real Life ◽

Glucose Monitoring ◽

Flash Glucose Monitoring

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Physiological or pathological hypertrophy of athlete’s heart syndrome

Patologiya krovoobrashcheniya i kardiokhirurgiya ◽

10.21688/1681-3472-2020-2-16-25 ◽

2020 ◽

Vol 24 (2) ◽

pp. 16 ◽

Cited By ~ 1

Author(s):

A. V. Gorbenko ◽

Yu. P. Skirdenko ◽

N. A. Nikolaev ◽

O. V. Zamahina ◽

S. A. Sherstyuk ◽

...

Keyword(s):

Left Ventricle ◽

Conflict Of Interest ◽

High Frequency ◽

Sports Medicine ◽

Low Frequency ◽

Physical Exertion ◽

Risk Groups ◽

Medical Society ◽

Adaptive Capabilities ◽

European Society Of Cardiology

Intense physical activity increases the risk of sudden death by 10–17 fold. Some of the most important tasks of modern pathophysiology in sports medicine include searching for factors that allow an athlete’s body to adapt to loads, understanding the line between adaptation and pathology and identifying risk groups of adaptation failure. It is necessary to distinguish between hypertrophic cardiomyopathy and true myocardial hypertrophy in athletes that results from the adaptation of the cardiovascular system to intense physical exertion. In Seattle, the American Medical Society of Sports Medicine together with the European Society of Cardiology proposed standards for the interpretation of electrocardiogram in athletes and considered criteria for the detection of pathological changes. The best functional state of an athlete and the effectiveness of his/her training are noted with high autonomy and high variability of heart rate. This is reflected in rhythmocardiogram data by increases in high frequency and root mean square of successive differences in heartbeats and a decrease in the low-frequency to high-frequency ratio. A promising direction in the study of markers of an athletic heart is the analysis of echocardiographic (EchoCG) images of young and professional athletes. According to EchoСG analysis, nonadaptive remodelling is the loss of the ellipsoid shape of the left ventricle in favour of a spherical one. In athletes, when assessing transmitral flow by EchoCG, a low A peak can be considered a reserve of adaptive capabilities of the heart and not a pathology. For athletes-dischargers, a concentric variant of changing the geometry of the myocardium is characteristic. Upon reaching the qualification of a candidate, master of sports an eccentric change in the left ventricle cavity prevails.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.Author contributions Conception and design: Y.P. Skirdenko Drafting the article: A.V. Gorbenko, O.V. Zamahina, S.A. Sherstyuk Critical revision of the article: N.A. Nikolaev Final approval of the version to be published: A.V. Gorbenko, Y.P. Skirdenko, N.A. Nikolaev, O.V. Zamahina, S.A. Sherstyuk, A.V. Ershov

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Frequency of flash glucose monitoring readings, hemoglobin A1c and time in range: a real life study in adults with type 1 diabetes

Acta Diabetologica ◽

10.1007/s00592-020-01577-7 ◽

2020 ◽

Vol 57 (11) ◽

pp. 1395-1397 ◽

Cited By ~ 1

Author(s):

Andrea Laurenzi ◽

Amelia Caretto ◽

Mariluce Barrasso ◽

Andrea Mario Bolla ◽

Nicoletta Dozio ◽

...

Keyword(s):

Type 1 Diabetes ◽

Hemoglobin A1c ◽

Real Life ◽

Glucose Monitoring ◽

Flash Glucose Monitoring ◽

Life Study ◽

Time In Range ◽

Real Life Study

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Flash glucose monitoring reduces glycemic variability and hypoglycemia: real-world data from Spain

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2019-001052 ◽

2020 ◽

Vol 8 (1) ◽

pp. e001052 ◽

Cited By ~ 4

Author(s):

Fernando Gomez-Peralta ◽

Timothy Dunn ◽

Katherine Landuyt ◽

Yongjin Xu ◽

Juan Francisco Merino-Torres

Keyword(s):

Real World ◽

Glucose Monitoring ◽

Glycemic Variability ◽

Real World Data ◽

Flash Glucose Monitoring ◽

Testing Frequency ◽

Scan Rate ◽

Time In Range ◽

Glycemic Markers ◽

Design And Methods

ObjectiveObservations in real-world settings support and extend findings demonstrated in randomized controlled trials that show flash glucose monitoring improves glycemic control. In this study, Spain-specific relationships between testing frequency and glycemic parameters were investigated under real-world settings.Research design and methodsDeidentified glucose and user scanning data were analyzed and readers were rank ordered into 20 equal sized groups by daily scan frequency. Glucose parameters were calculated for each group: estimated HbA1c, time below range (<70 and ≤54 mg/dL), within range (70–180 mg/dL), and above range (>180 mg/dL). Glycemic variability (GV) metrics were described and data obtained from sensors in Spain and worldwide were compared.ResultsSpanish users (n=22 949) collected 37.1 million glucose scans, 250 million automatically recorded glucose readings, and checked glucose values via a mean of 13 scans/day. Estimated HbA1c, time below 70 mg/dL, at or below 54 mg/dL, above 180 mg/dL, and GV metrics were significantly lower in the highest compared with lowest scan rate group (39.6 to 3.9 scans/day). Time-in-range was higher for the highest versus lowest scan rate group at 15.6 vs 11.5 hours/day, respectively. GV metrics correlated positively with time below 70 mg/dL, at or below 54 mg/dL, above 180 mg/dL, and negatively with time-in-range. The relationship between glucose metrics and scan rate was similar in Spain and worldwide. However, time in hypoglycemia in Spain was higher in the groups with lower scan rates.ConclusionsAs seen in clinical trials, flash glucose monitoring in real-world settings allows frequent glucose checks. High scan rates are associated with the favorable glycemic markers of increased time-in-range and reduced time in hyperglycemia and hypoglycemia, and GV. The same trends, with unique nuances, are observed in both Spanish and global data.

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Flash Glucose Monitoring Accepted in Daily Life of Children and Adolescents with Type 1 Diabetes and Reduction of Severe Hypoglycemia in Real-Life Use

Diabetes Technology & Therapeutics ◽

10.1089/dia.2018.0339 ◽

2019 ◽

Vol 21 (6) ◽

pp. 329-335 ◽

Cited By ~ 8

Author(s):

Anissa Messaaoui ◽

Sylvie Tenoutasse ◽

Laurent Crenier

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Daily Life ◽

Real Life ◽

Glucose Monitoring ◽

Severe Hypoglycemia ◽

Flash Glucose Monitoring

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Impact of flash glucose monitoring on glycaemic control and quality of life in patients with type 1 diabetes: A 18-month follow-up in real life

Diabetes & Metabolic Syndrome Clinical Research & Reviews ◽

10.1016/j.dsx.2019.12.007 ◽

2020 ◽

Vol 14 (2) ◽

pp. 65-69 ◽

Cited By ~ 2

Author(s):

S. Rouhard ◽

M. Buysschaert ◽

O. Alexopoulou ◽

V. Preumont

Keyword(s):

Quality Of Life ◽

Type 1 Diabetes ◽

Glycaemic Control ◽

Real Life ◽

Glucose Monitoring ◽

Flash Glucose Monitoring

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FREQUENCY ANALYSIS OF CARDIAC DATA OBTAINED THROUGH HOLTER MONITORING IN REAL LIVING CONDITIONS

CBU International Conference Proceedings ◽

10.12955/cbup.v7.1498 ◽

2019 ◽

Vol 7 ◽

pp. 870-874

Author(s):

Galya Nikolova Georgieva-Tsaneva

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

High Frequency ◽

Scientific Literature ◽

Real Life ◽

Low Frequency ◽

Holter Monitoring ◽

Heart Rate Variability Analysis ◽

Healthy Individuals ◽

Spectral Parameters

The paper presents frequency methods for estimating the variability of intervals between individual heart beats in Electrocardiogram. This parameter is known in the scientific literature as the Heart Rate Variability and with this method it is possible to make predictions about human health. Three frequency ranges have been studied: Very Low Frequency, Low Frequency, and High Frequency. The study in this paper was based on real cardiological data obtained from 33 patients suffering from heart fibrillations and 29 healthy individuals. The investigated records are obtained through a Holter monitoring of studied individuals in real life conditions. The obtained results show significantly lower values of the tested spectral parameters in the diseased individuals compared to the healthy controls. The accomplished study shows the effective applicability of the spectral methods of Heart Rate Variability analysis and the possibility of differentiation by the spectral parameters of the patients from healthy individuals.

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Sound Localization in Single-Sided Deaf Participants Provided With a Cochlear Implant

Frontiers in Psychology ◽

10.3389/fpsyg.2021.753339 ◽

2021 ◽

Vol 12 ◽

Author(s):

Alexandra Annemarie Ludwig ◽

Sylvia Meuret ◽

Rolf-Dieter Battmer ◽

Marc Schönwiesner ◽

Michael Fuchs ◽

...

Keyword(s):

Cochlear Implant ◽

Sound Localization ◽

High Frequency ◽

Real Life ◽

Low Frequency ◽

Normal Hearing ◽

Frequency Noise ◽

Speech Understanding ◽

Speech Understanding In Noise ◽

Single Sided Deafness

Spatial hearing is crucial in real life but deteriorates in participants with severe sensorineural hearing loss or single-sided deafness. This ability can potentially be improved with a unilateral cochlear implant (CI). The present study investigated measures of sound localization in participants with single-sided deafness provided with a CI. Sound localization was measured separately at eight loudspeaker positions (4°, 30°, 60°, and 90°) on the CI side and on the normal-hearing side. Low- and high-frequency noise bursts were used in the tests to investigate possible differences in the processing of interaural time and level differences. Data were compared to normal-hearing adults aged between 20 and 83. In addition, the benefit of the CI in speech understanding in noise was compared to the localization ability. Fifteen out of 18 participants were able to localize signals on the CI side and on the normal-hearing side, although performance was highly variable across participants. Three participants always pointed to the normal-hearing side, irrespective of the location of the signal. The comparison with control data showed that participants had particular difficulties localizing sounds at frontal locations and on the CI side. In contrast to most previous results, participants were able to localize low-frequency signals, although they localized high-frequency signals more accurately. Speech understanding in noise was better with the CI compared to testing without CI, but only at a position where the CI also improved sound localization. Our data suggest that a CI can, to a large extent, restore localization in participants with single-sided deafness. Difficulties may remain at frontal locations and on the CI side. However, speech understanding in noise improves when wearing the CI. The treatment with a CI in these participants might provide real-world benefits, such as improved orientation in traffic and speech understanding in difficult listening situations.

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