scholarly journals Association between variability in body mass index and development of type 2 diabetes: Panasonic cohort study

2021 ◽  
Vol 9 (1) ◽  
pp. e002123
Author(s):  
Hiroshi Okada ◽  
Masahide Hamaguchi ◽  
Momoko Habu ◽  
Kazushiro Kurogi ◽  
Hiroaki Murata ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Weight ◽  
Weight Gain ◽  
Body Mass ◽  
Cox Regression ◽  
Body Weight Gain ◽  
Design And Methods ◽  
Fourth Quartile

IntroductionContrasting results have been reported for the association between the variability in body weight and development of diabetes. In the present study, we evaluated the association between the variability in body mass index (BMI) and development of type 2 diabetes in 19 412 Japanese participants without obesity and without body weight gain or loss during the study period.Research design and methodsWe recorded body weight of the participants consecutively each year in Panasonic Corporation, Osaka, Japan from 2008 to 2014 to evaluate the variability of BMI. The participants with obesity (BMI ≥25 kg/m2) at baseline and body weight gain or loss from 2008 to 2014 (delta BMI ≥±1 kg/m2) were excluded from the study. In total, 416 participants developed type 2 diabetes from 2015 to 2018. We used coefficient of variation (CV) to represent the variability in BMI during 6 years of the study period.ResultsCox regression analyses revealed that the risk of developing type 2 diabetes was higher in the fourth quartile (HR 1.33; 95% CI 1.01 to 1.75) of CV of BMI than that in the first quartile (lowest quartile) of CV of BMI after adjusting for multiple confounding factors. The risk for developing diabetes increased by 11.1% per 1% increase in CV of BMI.ConclusionsIn conclusion, the variability in BMI is a risk factor for the development of diabetes in the Japanese population without obesity and without body weight gain or loss.

scholarly journals Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes

Diabetes Care ◽  
2006 ◽  
Vol 29 (8) ◽  
pp. 1826-1832 ◽  
Author(s):  
J. Martin ◽  
Z. Q. Wang ◽  
X. H. Zhang ◽  
D. Wachtel ◽  
J. Volaufova ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Body Weight Gain ◽  
Chromium Picolinate

scholarly journals I-M-150847, a novel GLP-1 and GIP receptor dual agonist, reduces body weight gain and improves glycemic control in the rodent model of type 2 diabetes and obesity.

2021 ◽  
Author(s):  
PRASENJIT MITRA ◽  
Rathin Bauri ◽  
Shilpak Bele ◽  
Jhansi Edelli ◽  
Sourav Dasadhikari ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Single Amino Acid ◽  
The Novel ◽  
Diabetes And Obesity ◽  
Dual Agonist ◽  
Gip Receptor

We report the discovery of a novel glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor dual agonist that shows balanced agonism towards both the incretin receptor. The dual agonism of GLP-1 and GIP receptor was achieved by replacing the tryptophan cage of exendin-4 with the C- terminal undecapeptide sequence of oxyntomodulin along with a single amino acid substitution from histidine to tyrosine at the amino terminus of the peptide. The structural modification places lysine 30 of the novel incretin agonist in frame with the corresponding lysine residue in the native GIP sequence. The novel incretin agonist, named I-M-150847, promotes robust glucose-stimulated insulin exocytosis in cultured pancreatic beta cells. Chronic administration of I-M-150847 to mice fed on the high-fat diet improves glucose tolerance, decreases food intake, decreases visceral adiposity and body weight gain demonstrating its therapeutic potential in ameliorating type 2 Diabetes and Obesity.

scholarly journals Social Isolation Affects the Development of Obesity and Type 2 Diabetes in Mice

Endocrinology ◽  
2007 ◽  
Vol 148 (10) ◽  
pp. 4658-4666 ◽  
Author(s):  
Katsunori Nonogaki ◽  
Kana Nozue ◽  
Yoshitomo Oka
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Adipose Tissue ◽  
Weight Gain ◽  
Social Isolation ◽  
Food Consumption ◽  
Leptin Receptor ◽  
Body Weight Gain ◽  
Kkay Mice

Social isolation is associated with increased risks of mortality and morbidity. In this study, we show that chronic individual housing accelerated body weight gain and adiposity in KK mice but not C57BL6J mice, and fully developed diabetes in KKAy mice. Individually housed KK and KKAy mice increased body weight gain over the initial 2 wk without increased daily average food consumption compared with group-housed animals. The individually housed KK and KKAy mice then gradually increased food consumption for the next 1 wk. The chronic social isolation-induced obesity (SIO) was associated with hyperleptinemia and lower plasma corticosterone and active ghrelin levels but not hyperinsulinemia. Elevated plasma leptin in the SIO suppressed expression of 5-HT2C receptor in white adipose tissue. The SIO was also associated with decreased expression of β3-adrenergic receptors in white adipose tissue and hypothalamic leptin receptor, which might be secondary to the enhanced adiposity. Interestingly, social isolation acutely reduced food consumption and body weight gain compared with group-housed obese db/db mice with leptin receptor deficiency. Social isolation-induced hyperglycemia in KKAy mice was associated with increased expression of hepatic gluconeogenetic genes independent of insulin. These findings suggest that social isolation promotes obesity due to primary decreased energy expenditure and secondary increased food consumption, which are independent of the disturbed leptin signaling, in KK mice, and develops into insulin-independent diabetes associated with increased expression of hepatic gluconeogenetic genes in KKAy mice. Thus, social isolation can be included in the environmental factors that contribute to the development of obesity and type 2 diabetes.

scholarly journals Childhood Body Mass Index and Fasting Glucose and Insulin Predict Adult Type-2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium

2020 ◽  
Author(s):  
Tian Hu ◽  
David R. Jacobs Jr. ◽  
Alan R. Sinaiko ◽  
Lydia A. Bazzano ◽  
Trudy L. Burns ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Mass ◽  
Fasting Glucose ◽  
Self Report ◽  
Adult Type ◽  
Childhood Body Mass Index ◽  
Increased Risk ◽  
Design And Methods

Objective: To examine childhood body mass index (BMI), fasting glucose and insulin in relation to incident adult type-2 diabetes mellitus (T2DM). <p>Research Design and Methods: We used data from The International Childhood Cardiovascular Cohort Consortium. Data included childhood measurements (age 3-19) obtained during the 1970s-90s, a health questionnaire including self-report of adult T2DM (occurrence age, medication use) obtained at mean age 40 years, and a medical diagnosis registry (Finland). </p> <p>Results: The sample included 6,738 participants. Of these, 436 (6.5%) reported onset of T2DM between ages 20-59 (mean 40.8) years, and 86% of them reported use of a confirmed anti-diabetic medication. BMI and glucose (age- and sex-standardized) were associated with incident T2DM after adjustment for cohort, country, sex, race, age and calendar year of measurement. Increasing levels of childhood BMI and glucose were related to incrementally increased risk of T2DM beginning at age 30, beginning at cut points below the 95<sup>th</sup> percentile for BMI and below 100 mg/dL for glucose. Insulin was positively associated with adult T2DM after adjustment for BMI and glucose and added to T2DM discrimination. </p> <p>Conclusions: Childhood BMI and glucose are predictors of adult T2DM at levels previously considered to be within the normal range. These easy to apply measurements are appealing from a clinical perspective. Fasting insulin has the potential to be an additional predictor.</p>

scholarly journals Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex

Antioxidants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 537 ◽  
Author(s):  
Anna Tresserra-Rimbau ◽  
Sara Castro-Barquero ◽  
Facundo Vitelli-Storelli ◽  
Nerea Becerra-Tomas ◽  
Zenaida Vázquez-Ruiz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Mass ◽  
Cox Regression ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Dietary Polyphenols ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations.

scholarly journals Sleep apnoea and incident malignancy in type 2 diabetes

2021 ◽  
pp. 00036-2021
Author(s):  
Sarah Driendl ◽  
Michael Arzt ◽  
Claudia S. Zimmermann ◽  
Bettina Jung ◽  
Tobias Pukrop ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Mass ◽  
Cox Regression ◽  
Smoking Status ◽  
Ambulatory Monitoring ◽  
Sleep Apnoea ◽  
Night Time ◽  
Peripheral Oxygen Saturation

BackgroundSleep apnoea (SA) and type 2 diabetes (T2D) have been linked to malignancy. The aim of the present study was to evaluate the association between SA and incidence of malignancy in patients with T2D.MethodsThe DIACORE (DIAbetes COhoRtE) study is a prospective, population-based cohort study in T2D patients. In the SDB (sleep-disordered breathing) sub-study, the apnoea-hypopnoea index (AHI), oxygen desaturation index (ODI) and percentage of night-time spent below a peripheral oxygen saturation of 90% (TSat90%) were assessed using a two-channel ambulatory monitoring device. Malignancy diagnoses were gathered using self-reported medical history data validated by medical records. Hazard ratios (HR) for incident malignancy were derived by Cox regression adjusting for sex, age, body-mass index, smoking status, alcohol intake, socioeconomic status and HbA1c.ResultsOf 1239 patients with T2D (mean age 67 years, 41% female, mean body-mass index 30.9 kg m−2), 79 (6.4%) were first-time diagnosed with a malignancy within a median follow-up period of 2.7 (interquartile range 2.2; 4.5) years. AHI, ODI and TSat90% were not associated with incident malignancy. In subgroup analysis, women showed increased cancer risk per AHI unit (adjusted HR 1.03 per AHI unit, 95% CI [1.00–1.06], p=0.028) and severe SA (defined as AHI≥30 h−1; adjusted HR 4.19, 95% CI [1.39–12.77], p=0.012). This was not seen in men, and a significant interaction was observed (interaction terms, p=0.048, p=0.033, respectively).ConclusionSA was not associated with incident malignancy in T2D patients. However, stratified analysis revealed a significant association between SA and incident malignancy in women, but not in men.

scholarly journals Childhood Body Mass Index and Fasting Glucose and Insulin Predict Adult Type-2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium

2020 ◽  
Author(s):  
Tian Hu ◽  
David R. Jacobs Jr. ◽  
Alan R. Sinaiko ◽  
Lydia A. Bazzano ◽  
Trudy L. Burns ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Mass ◽  
Fasting Glucose ◽  
Self Report ◽  
Adult Type ◽  
Childhood Body Mass Index ◽  
Increased Risk ◽  
Design And Methods

Objective: To examine childhood body mass index (BMI), fasting glucose and insulin in relation to incident adult type-2 diabetes mellitus (T2DM). <p>Research Design and Methods: We used data from The International Childhood Cardiovascular Cohort Consortium. Data included childhood measurements (age 3-19) obtained during the 1970s-90s, a health questionnaire including self-report of adult T2DM (occurrence age, medication use) obtained at mean age 40 years, and a medical diagnosis registry (Finland). </p> <p>Results: The sample included 6,738 participants. Of these, 436 (6.5%) reported onset of T2DM between ages 20-59 (mean 40.8) years, and 86% of them reported use of a confirmed anti-diabetic medication. BMI and glucose (age- and sex-standardized) were associated with incident T2DM after adjustment for cohort, country, sex, race, age and calendar year of measurement. Increasing levels of childhood BMI and glucose were related to incrementally increased risk of T2DM beginning at age 30, beginning at cut points below the 95<sup>th</sup> percentile for BMI and below 100 mg/dL for glucose. Insulin was positively associated with adult T2DM after adjustment for BMI and glucose and added to T2DM discrimination. </p> <p>Conclusions: Childhood BMI and glucose are predictors of adult T2DM at levels previously considered to be within the normal range. These easy to apply measurements are appealing from a clinical perspective. Fasting insulin has the potential to be an additional predictor.</p>

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