scholarly journals PO 8538 STRENGTHENING SOCIAL STRATEGIES TO ENGAGE SUB-SAHARAN AFRICAN SOCIETIES TO VALUE CLINICAL RESEARCH: THE EXPERIENCE IN CONDUCTING CLINICAL TRIALS IN LAMBARéNé

2019 ◽  
Vol 4 (Suppl 3) ◽  
pp. A51.1-A51
Author(s):  
Pamela C Angoissa Minsoko ◽  
Selidji T Agnandji
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Community Engagement ◽  
Sub Saharan Africa ◽  
Social Meaning ◽  
Willingness To Participate ◽  
The Social ◽  
Social Meanings ◽  
Sub Saharan ◽  
Social Components

BackgroundOver the last two decades, clinical research activities have increased significantly in sub-Saharan Africa but societal engagement to make research socially and economically valuable is limited. Thus, engaging communities when designing clinical research and promoting social impacts of research are becoming key objectives among stakeholders involved in clinical research in sub-Saharan Africa. However, there is a need to define concepts and indicators to assess the strength of community engagement as well as the social impacts of clinical research.Here, we hypothesised that the social meanings of willingness to participate and compliance to clinical trial procedures are relevant indicators to assess community engagement.MethodsWe conducted a retrospective, prospective case study of clinical trials conducted in CERMEL between 1995 and 2017. We performed a social meaning framework analysis of the following processes: protocol design, ethical and regulatory clearance, informed consent and medical study procedures. We identified the social meanings of each procedure according to the involvement of social components (actors, ideas, communication strategies).ResultsA total of 42 clinical trials were identified in the ClinicalTrials.gov and Pan-African Clinical Trials Registry databases and confirmed by the top management of CERMEL. Between 1995 and 2004, there was little social meaning connected to trial procedures. This period was associated with poor compliance to study procedures. Between 2005 and 2017, compliance to study procedures improved. Detailed results will be presented during the meeting.ConclusionThe rise in willingness to participate in clinical research and improved compliance with study procedures were associated with the introduction of social components to medical procedures. Both indicators may be relevant to assess the strength of community engagement.

scholarly journals The conundrum of clinical trials and standard of care in sub-Saharan Africa – the research nurse perspective

2019 ◽  
Vol 24 (8) ◽  
pp. 649-660 ◽  
Author(s):  
Jane Frances Ndyetukira ◽  
Richard Kwizera ◽  
Florence Kugonza ◽  
Cynthia Ahimbisibwe ◽  
Carol Namujju ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Standard Of Care ◽  
Sub Saharan Africa ◽  
Research Nurse ◽  
Loss To Follow Up ◽  
Resource Limited ◽  
Research Nurses ◽  
Sub Saharan

Background Nurses form a very important part of the health workforce in sub-Saharan Africa. Research nurses are critical to the implementation of clinical trials. The duties and responsibilities of a research nurse are complex and continue to evolve as new practices and guidelines are formulated. Aims In this paper, we have highlighted the major contributions of research nurses in HIV clinical trials in sub-Saharan Africa from the unique perspective of Ugandan nurses. Methods The requirements and challenges of two multi-site, randomised cryptococcal meningitis clinical trials in Uganda were assessed from the perspective of research nurses conducting complex research in resource-limited settings. Results Over the course of 8 years, approximately 1739 participants were screened and 934 people were enrolled into the two trials. The nurses found that patient education and engagement were among the most important predictors of success in minimising loss to follow-up. Conclusions Research nurses played a key role in communicating clinical research goals to patients, obtaining informed consent, minimising loss to follow-up, and ensuring that research practices are translated and implemented into standard of care. However, there remains a need to integrate the same level of care provided in clinical research studies to non-study patients.

scholarly journals Assessing clinical investigators’ perceptions of relevance and competency of clinical trials skills: An international AIDS Malignancy Consortium (AMC) study

2020 ◽  
pp. 1-6
Author(s):  
Jeannette Y. Lee ◽  
Shelly V Lensing ◽  
Maria T. Botello-Harbaum ◽  
Rebecca Medina ◽  
Meredith Zozus
Keyword(s):  
Clinical Trials ◽  
Clinical Research ◽  
Task Force ◽  
Perceived Competence ◽  
Sub Saharan Africa ◽  
People Living With Hiv ◽  
Specimen Collection ◽  
Average Proportion ◽  
Sub Saharan ◽  
Safety Considerations

Abstract Introduction: The AIDS Malignancy Consortium (AMC) conducts clinical trials of therapeutic and prevention strategies for cancer in people living with HIV. With its recent expansion to Sub-Saharan Africa and Latin America, there was a need to increase the competence of clinical investigators (CIs) to implement clinical trials in these regions. Methods: AMC CIs were invited to complete a survey to assess role-relevance and self-perceived competence based on the Joint Task Force for Clinical Trials Competency domains. Results: A total of 40 AMC CIs were invited to complete the questionnaire and 35 responded to the survey. The data management and informatics and engaging with communities’ domains were lowest in the average proportion of CIs rating themselves high (scores of 3–4) for self-perceived competency (46.6% and 44.2%) and role-relevance (61.6% and 67.5%), whereas, the ethical and participant safety considerations domain resulted in the highest score for competency (86.6%) and role-relevance (93.3%). In the scientific concepts and research design domain, a high proportion rated for competency in evaluating study designs and scientific literature (71.4% and 74.3%) but a low proportion for competency for designing trials and specimen collection protocols (51.4% and 54.3%). Conclusions: Given the complexity of AMC clinical research, these results provide evidence of the need to develop training for clinical research professionals across domains where self-perceived competence is low. This assessment will be used to tailor and prioritize the AMC Training Program in clinical trial development and management for AMC CIs.

scholarly journals The Promise, Problems, and Pitfalls of Including Pregnant Women in Lassa Fever Vaccine Clinical Trials: A Qualitative Analysis of Sub-Sahara Africa Investigators' Perception

2021 ◽  
Author(s):  
Kolawole A Salami ◽  
Henshaw E Mandi ◽  
Nathalie Imbault ◽  
Nadia G Tornieporth
Keyword(s):  
Clinical Trials ◽  
Pregnant Women ◽  
Community Engagement ◽  
Safety Data ◽  
Lassa Fever ◽  
West African ◽  
Sub Saharan Africa ◽  
African Countries ◽  
Sub Saharan ◽  
Promise Problems

Abstract Background Lassa fever run a uniquely severe course in pregnancy. There are plans for Lassa fever vaccine clinical trials in endemic West African countries. We tried to assess the perception of West African investigators to including pregnant women in these studies. Methods Interviews were conducted with eight investigators from sub-Saharan Africa. Six of them from West Africa. Data were analyzed thematically. Results Respondents had limited experience with pregnant women in clinical trials but desired a paradigm shift. They identified pregnant women's willingness, a robust community engagement strategy, and adequate safety data as enablers, while lack of safety data, persistent fears about potential harm to pregnant women and offspring, and inappropriate community engagement activities as potential barriers. Conclusion The inclusion of pregnant women in Lassa fever vaccine clinical trials should be a priority of vaccine developers. Investigators are willing to conduct these studies provided adequate measures to ensure safety is in place.

scholarly journals Conducting clinical trials in sub-Saharan Africa: challenges and lessons learned from the Malawi Cryptosporidium study

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Neema Toto ◽  
Elaine Douglas ◽  
Markus Gmeiner ◽  
Lynn K. Barrett ◽  
Robert Lindblad ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Lessons Learned ◽  
Sub Saharan Africa ◽  
Sub Saharan

Slaves and society in Western Africa, c. 1445—c. 1700

1980 ◽  
Vol 21 (3) ◽  
pp. 289-310 ◽  
Author(s):  
J. D. Fage
Keyword(s):  
Social Mobility ◽  
Social Groups ◽  
Early Years ◽  
Sub Saharan Africa ◽  
Western Africa ◽  
The Social ◽  
African Slaves ◽  
Limited Supply ◽  
Sub Saharan

Published European first-hand accounts of the coastlands from Senegal to Angola for the period c. 1445-c. 1700 are examined to see what light they throw on the extent to which institutions of servitude in pre-colonial sub-Saharan Africa were autonomous developments or a response to external demands for African slaves. It seems clear that when, in the early years of this period, European traders first approached societies along the western African coasts, they were commonly offered what they called ‘slaves’ in exchange for the goods they had brought. But it would be wrong to conclude from this that a slave class was necessarily a feature of western African coastal societies when these were first contacted by Europeans. It is clear, for instance, that the Europeans preferred to deal with societies which had developed monarchical governments, whose leaders had control of sufficient surpluses to make trade worthwhile. The evidence suggests that in these societies most individuals were dependants of a ruling and entrepreneurial elite, but that there was also social mobility. A category of dependants that particularly attracted the notice of the European observers was women, whom men of power and wealth tended to accumulate as wives (and hence as the potential mothers of still more dependants). The necessarily limited supply of women may have been a factor encouraging such men to seek to increase their followings, and thus their status, power and wealth, by recruiting other dependants by forcible, judicial and economic means. While many such dependants, or their offspring, would be assimilated into the social groups commanded by their masters, the latter were certainly willing to contemplate using recently acquired or refractory recruits in other ways, such as exchanging them for alternative forms of wealth.

The Social Characterizations of Price: The Fool, the Faithful, the Frivolous, and the Frugal

2008 ◽  
Vol 26 (4) ◽  
pp. 363-379 ◽  
Author(s):  
Frederick F. Wherry
Keyword(s):  
Reference Point ◽  
Systematic Approach ◽  
Social Location ◽  
Social Meaning ◽  
Ideal Types ◽  
The Social ◽  
Social Meanings ◽  
Meaning Systems ◽  
Pricing System ◽  
Meaning Of Money

This article extends both Viviana Zelizer's discussion of the social meaning of money and Charles Smith's proposal that pricing is a definitional practice to the under-theorized realm of the social meanings generated in the pricing system. Individuals are attributed with calculating or not calculating whether an object or service is “worth” its price, but these attributions differ according to the individual's social location as being near to or far from a societal reference point rather than by the inherent qualities of the object or service purchased. Prices offer seemingly objective (quantitative) proof of the individual's “logic of appropriateness”—in other words, people like that pay prices such as those. This article sketches a preliminary but nonexhaustive typology of the social characterizations of individuals within the pricing system; these ideal types—the fool, the faithful, the frugal, and the frivolous—and their components offer a systematic approach to understanding prices as embedded in and constituents of social meaning systems.

Transcontinental Modernism. M&G as an Unité d’habitation and a factory complex in Mozambique

2010 ◽  
pp. 70-73
Author(s):  
Ana Tostões ◽  
Maria Manuel Oliveira
Keyword(s):  
Social Program ◽  
Sub Saharan Africa ◽  
Industrial Complex ◽  
Architectural Heritage ◽  
Technological Approach ◽  
The Social ◽  
Sub Saharan ◽  
Overseas Territories ◽  
Architectural Modernism

With the aim of contributing to the documentation and conservation of the modern architectural heritage, this paper presents Monteiro & Giro Complex (M&G), built during the 50’s in Quelimane, Mozambique, with the goal of stressing the modernity of the social program and the technological approach. If one wants to gain a better understanding of the worldwide Diaspora of architectural modernism, it is essential to document and analyse the important heritage of sub–Saharan Africa. Modern architectural debates have been reproduced, transformed, contested and sometimes even improved in distant lands and overseas territories. These contradictory aspects of Modernist practice are revealed in the programmatic, technological and structural M&G industrial Complex.

scholarly journals Willingness to Participate in Vaccine-Related Clinical Trials among Older Adults

2018 ◽  
Vol 15 (8) ◽  
pp. 1743 ◽  
Author(s):  
Divyanshu Raheja ◽  
Evelyn Davila ◽  
Eric Johnson ◽  
Rijalda Deović ◽  
Michele Paine ◽  
...  
Keyword(s):  
Older Adults ◽  
Clinical Trials ◽  
Clinical Research ◽  
Elderly Person ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Willingness To Participate ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Research Findings

The purpose of this study is to understand among a convenience sample of 400 adults aged 60 years of age or older (1) reasons for being willing or unwilling to participate in a vaccine clinical research study and (2) overall perceptions about vaccine clinical research. A cross-sectional study using a sample of older adults residing in the metro-Atlanta area and surrounding neighborhoods was conducted. The study questionnaire contained 37 questions, including questions about socio-demographics and perceptions about clinical trial processes. Statistical analysis was conducted using logistic regression. The adjusted modeling results indicated that sex, distance to research clinic, and being informed about the research findings played a role in the likelihood of an elderly person participating in a vaccine study. Males were more likely to participate in clinical trials as compared to females (OR: 2.486; CI: 1.042–5.934). Most participants were willing to travel up to 25 miles from the research clinic. Of the respondents, 45% were unlikely to participate if the results of the current trial are not shared. Improving access to clinical trials in terms of distance traveled and ensuring streamlined processes to inform participants about the results of the trial in the future would increase willingness to participate in vaccine clinical trials. The survey could serve as a useful tool for conducting vaccine studies and other clinical trials by understanding the barriers specific to the elderly.

scholarly journals Social inferences from the use of just as an exclusive particle

2021 ◽  
Vol 6 (1) ◽  
pp. 746
Author(s):  
William C. Thomas
Keyword(s):  
Recent Work ◽  
Social Perception ◽  
Speech Acts ◽  
Social Meaning ◽  
Semantic Meaning ◽  
The Social ◽  
Social Meanings ◽  
Discourse Particle ◽  
Social Inferences

Recent work has begun to investigate the interaction between semantics and social meaning. This study contributes to that line of inquiry by investigating how particular social meanings that are popularly believed to arise from the English discourse particle just are related to the conventional semantic meaning of just. In addition to proposing an inferential process by which the social meanings associated with just arise, this paper reports the results of a social perception experiment designed to test whether those social inferences arise when just is used in particular speech acts and whether they depend on the speaker’s gender and level of authority relative to the addressee. The use of just was found to significantly increase the perceived insecurity of men but not of women. This suggests that listeners may more strongly perceive speaker qualities that stereotypes cause them not to expect.

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