Building Quantitative Cross-Cultural Databases From Ethnographic Records: Promise, Problems and Principles

Quantitative cross-cultural databases can help uncover structure and diversity across human populations. These databases have been constructed using a variety of methodologies and have been instrumental for building and testing theories in the social sciences. The processes and assumptions behind the construction of cross-cultural databases are not always openly discussed by creators or fully appreciated by their users. Here, we scrutinize the processes used to generate quantitative cross-cultural databases, from the point of ethnographic fieldwork to the processing of quantitative cross-cultural data. We outline challenges that arise at each stage of this process and discuss the strengths and limitations of how existing databases have handled these challenges. We suggest a host of best practices for cross-cultural database construction, and stress the importance of coding source meta-data and using this meta-data to identify and adjust for source biases. This paper explicitly discusses the processes, problems, and principles behind cross-cultural database construction, and ultimately seeks to promote rigorous cross-cultural comparative research.

The Promise, Problems, and Pitfalls of Including Pregnant Women in Lassa Fever Vaccine Clinical Trials: A Qualitative Analysis of Sub-Sahara Africa Investigators' Perception

Background Lassa fever run a uniquely severe course in pregnancy. There are plans for Lassa fever vaccine clinical trials in endemic West African countries. We tried to assess the perception of West African investigators to including pregnant women in these studies. Methods Interviews were conducted with eight investigators from sub-Saharan Africa. Six of them from West Africa. Data were analyzed thematically. Results Respondents had limited experience with pregnant women in clinical trials but desired a paradigm shift. They identified pregnant women's willingness, a robust community engagement strategy, and adequate safety data as enablers, while lack of safety data, persistent fears about potential harm to pregnant women and offspring, and inappropriate community engagement activities as potential barriers. Conclusion The inclusion of pregnant women in Lassa fever vaccine clinical trials should be a priority of vaccine developers. Investigators are willing to conduct these studies provided adequate measures to ensure safety is in place.

Mesenchymal Stem Cells as a Gene Delivery Tool: Promise, Problems, and Prospects

The cell-based approach in gene therapy arises as a promising strategy to provide safe, targeted, and efficient gene delivery. Owing to their unique features, as homing and tumor-tropism, mesenchymal stem cells (MSCs) have recently been introduced as an encouraging vehicle in gene therapy. Nevertheless, non-viral transfer of nucleic acids into MSCs remains limited due to various factors related to the main stakeholders of the process (e.g., nucleic acids, carriers, or cells). In this review, we have summarized the main types of nucleic acids used to transfect MSCs, the pros and cons, and applications of each. Then, we have emphasized on the most efficient lipid-based carriers for nucleic acids to MSCs, their main features, and some of their applications. While a myriad of studies have demonstrated the therapeutic potential for engineered MSCs therapy in various illnesses, optimization for clinical use is an ongoing challenge. On the way of improvement, genetically modified MSCs have been combined with various novel techniques and tools (e.g., exosomes, spheroids, 3D-Bioprinting, etc.,) aiming for more efficient and safe applications in biomedicine.

On a poset of quantum exact promise problems

Two of the most well-known quantum algorithms, those introduced by Deutsch–Jozsa and Bernstein–Vazirani, can solve promise problems with just one function query, showing an oracular separation with deterministic classical algorithms. In this work, we generalise those methods to study a family of quantum algorithms that can, with just one query, exactly solve promise problems stated over Boolean functions. We also show that these problems can be naturally ordered, inducing a partially ordered set of promise problems. We study the properties of such a poset, showing that the Deutsch–Jozsa and Bernstein–Vazirani problems are, in a certain sense, extremal problems in it, determining some of its automorphisms and proving that it is connected. We also prove that, for the problems in the poset, the corresponding classical query complexities can take any value between 1 and $$2^{n-1}+1$$ 2 n - 1 + 1 .

SIGACT News Complexity Theory Column 108

Warmest thanks to Rafael Pass and Muthu Venkitasubramaniam for this issue's guest column, "Average-Case Complexity Through the Lens of Interactive Puzzles." When I mentioned to them that my introduction would have a section on Alan Selman's passing, they immediately wrote back that they were very sorry to hear of Alan's passing, and mentioned (as you will see discussed in the second page of their article), "The main problem that we are addressing actually goes back to a paper of Even, Selman, and Yacobi from 1984: "The Complexity of Promise Problems with Applications to Public-Key Cryptography'." It is beautiful, and a tribute to the lasting influence of Alan's research, that in the 2020s his work from many decades earlier is helping shape the field's dialogue.

Evidence-Based Policing and Fatal Police Shootings: Promise, Problems, and Prospects

The promise of evidence-based policing is to reduce harm with better research for targeting, testing, and tracking police actions. The problems of using evidence-based policing to reduce harm are found in the emotional dimensions of ethics and risk. These problems are most pronounced with fatal police shootings, where the risks of injury to American police are often framed as a zero-sum choice in relation to the ethics of taking citizens’ lives. Yet evidence-based policing offers good prospects for reframing the debate over fatal police shootings, in ways that could reduce harm to both police and citizens. This volume offers substantial new evidence for initiatives at all levels of U.S. government that could help to save lives in police encounters with citizens. Putting that evidence to work remains the major challenge facing the American police.