scholarly journals Comparison of neonatal outcomes of small for gestational age and appropriate for gestational age preterm infants born at 28–36 weeks of gestation: a multicentre study in Ethiopia

2020 ◽  
Vol 4 (1) ◽  
pp. e000740
Author(s):  
Netsanet Workneh Gidi ◽  
Robert L Goldenberg ◽  
Assaye K Nigussie ◽  
Elizabeth McClure ◽  
Amha Mekasha ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Late Onset ◽  
Early Recognition ◽  
Neonatal Outcomes ◽  
P Value ◽  
Prolonged Hospitalisation ◽  
Increased Risk ◽  
Appropriate For Gestational Age

PurposeThe aim of this study was to assess morbidity and mortality pattern of small for gestational age (SGA) preterm infants in comparison to appropriate for gestational age (AGA) preterm infants of similar gestational age.MethodWe compared neonatal outcomes of 1336, 1:1 matched, singleton SGA and AGA preterm infants based on their gestational age using data from the study ‘Causes of Illness and Death of Preterm Infants in Ethiopia (SIP)’. Data were analysed using SPSS V.23. ORs and 95% CIs and χ2 tests were done, p value of <0.05 was considered statistically significant.ResultThe majority of the infants (1194, 89%) were moderate to late preterm (32–36 weeks of gestation), 763 (57%) were females. Male preterm infants had higher risk of being SGA than female infants (p<0.001). SGA infants had increased risk of hypoglycaemic (OR and 95% CI 1.6 (1.2 to 2.0), necrotising enterocolitis (NEC) 2.3 (1.2 to 4.1), polycythaemia 3.0 (1.6 to 5.4), late-onset neonatal sepsis (LOS) 3.6 (1.1 to 10.9)) and prolonged hospitalisation 2.9 (2.0 to 4.2). The rates of respiratory distress syndrome (RDS), apnoea and mortality were similar in the SGA and AGA groups.ConclusionNeonatal complications such as hypoglycaemic, NEC, LOS, polycythaemia and prolonged hospitalisation are more common in SGA infants, while rates of RDS and mortality are similar in SGA and AGA groups. Early recognition of SGA status, high index of suspicion and screening for complications associated and timely intervention to prevent complications need due consideration.

scholarly journals Clinical Stratification of Pregnant COVID-19 Patients based on Severity: A Single Academic Center Experience

2021 ◽  
Vol 38 (05) ◽  
pp. 515-522
Author(s):  
Marissa Berry ◽  
Amanda Wang ◽  
Shannon M. Clark ◽  
Hassan M. Harirah ◽  
Sangeeta Jain ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Disease Severity ◽  
Gestational Age ◽  
Laboratory Data ◽  
Population Characteristics ◽  
Neonatal Outcomes ◽  
P Value ◽  
Asymptomatic Patients ◽  
Increased Risk ◽  
Maternal And Neonatal Outcomes

Objective This study aimed to describe baseline characteristics of a cohort of pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and determine if these correlate with disease severity and perinatal outcomes. Study Design This was a retrospective cohort trial conducted at the University of Texas Medical Branch Galveston, Texas. All pregnant women presented to our medical center, who were screened and tested positive for SARS-CoV-2 virus, were included. We stratified our study population in three groups: asymptomatic, symptomatic not requiring oxygen therapy, and patients requiring oxygen support to maintain oxygen saturation >94%. Relevant population characteristics, laboratory data, and maternal and neonatal outcomes were abstracted. A p-value <0.05 was considered statistically significant. Results Between March and July 2020, 91 women tested positive for SARS-CoV-2 upon admission to our labor and delivery unit. Among these, 61.5% were asymptomatic, 34.1% were symptomatic, and 4.4% required oxygen support. Our population was mainly Hispanic (80.2%), multiparous (76.9%), obese (70.3%), and with a median age of 27 years. Median gestational age at symptom onset or diagnosis was 36 weeks. Significant differences were found between gestational age and disease severity. Maternal characteristics including age, body mass index (BMI), and presence of comorbid conditions did not appear to influence severity of SARS-CoV-2 infection. Significant laboratory findings associated with increasing disease severity included decreasing hemoglobin and white blood cell count, lymphopenia, and increasing levels of inflammatory markers including CRP, ferritin, and procalcitonin. Maternal and neonatal outcomes did not differ among groups. No SARS-CoV-2 was detected by polymerase chain reaction testing in neonates of mothers with COVID-19. Conclusion Pregnant patients with COVID-19 infection are predominantly asymptomatic. Patients appear to be at increased risk for more severe infection requiring oxygen support later in pregnancy. Key Points

Neonatal Outcomes of Small for Gestational Age Preterm Infants in Canada

2011 ◽  
Vol 29 (02) ◽  
pp. 87-94 ◽  
Author(s):  
Xiangming Qiu ◽  
Abhay Lodha ◽  
Prakesh Shah ◽  
K. Sankaran ◽  
Mary Seshia ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Neonatal Outcomes

scholarly journals Prediction of Late-Onset Small for Gestational Age and Fetal Growth Restriction by Fetal Biometry at 35 Weeks and Impact of Ultrasound–Delivery Interval: Comparison of Six Fetal Growth Standards

2021 ◽  
Vol 10 (13) ◽  
pp. 2984
Author(s):  
Ricardo Savirón-Cornudella ◽  
Luis Mariano Esteban ◽  
Rocío Aznar-Gimeno ◽  
Peña Dieste-Pérez ◽  
Faustino R. Pérez-López ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Detection Rate ◽  
Late Onset ◽  
University Hospital ◽  
Detection Rates ◽  
Growth Standards ◽  
Fetal Biometry ◽  
Increased Risk

Small-for-gestational-age (SGA) infants have been associated with increased risk of adverse perinatal outcomes (APOs). In this work, we assess the predictive ability of the ultrasound-estimated percentile weight (EPW) at 35 weeks of gestational age to predict late-onset SGA and APOs, according to six growth standards, and whether the ultrasound–delivery interval influences the detection rate. To this purpose, we analyze a retrospective cohort study of 9585 singleton pregnancies. EPWs at 35 weeks were calculated to the customized Miguel Servet University Hospital (MSUH) and Figueras standards and the non-customized MSUH, Fetal Medicine Foundation (FMF), INTERGROWTH-21st, and WHO standards. As results of our analysis, for a 10% false positive rate, the detection rates for SGA ranged between 48.9% with the customized Figueras standard (AUC 0.82) and 60.8% with the non-customized FMF standard (AUC 0.87). Detection rates to predict SGA by ultrasound–delivery interval (1–6 weeks) show higher detection rates as intervals decrease. APOs detection rates ranged from 27.0% with FMF to 7.9% with the Figueras standard. In conclusion, the ability of EPW to predict SGA at 35 weeks is good for all standards, and slightly better for non-customized standards. The APO detection rate is significantly greater for non-customized standards.

IGF-II expression and methylation in small for gestational age infants

2015 ◽  
Vol 28 (5-6) ◽  
Author(s):  
Shulian Zhang ◽  
Guanpeng Zhai ◽  
Jin Wang ◽  
Wenjing Shi ◽  
Rong Zhang ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Newborn Infants ◽  
Adult Life ◽  
Adverse Outcomes ◽  
Large For Gestational Age ◽  
Increased Risk ◽  
The Status ◽  
Appropriate For Gestational Age

AbstractLow birth weight is associated with an increased risk of adverse outcomes in many diseases in adult life. We investigated the expression of IGF-II and the status of differentially methylated regions (DMR) in small for gestational age (SGA) infants after birth.Plasma IGF-II, IGF-II receptor (IGF2R), IGF-I, and IGF-binding protein 3 (IGFBP3) levels were measured after birth in 150 newborn infants. These included 30 term appropriate for gestational age (AGA), 30 term SGA, 30 term large for gestational age (LGA), 30 preterm AGA, and 30 preterm SGA infants.Plasma IGF-II levels after birth were lower in both term SGA (435.1±33.82 vs. 620.4±44.79, p=0.002) and LGA infants (483.7±33.8 vs. 620.42±44.79, p=0.018) than in term AGA infants. The expression ofIGF-II was associated with birth weight and expressed at high levels, which suggests that IGF-II may continue to play an important role after birth.

Feeding tolerance of preterm infants appropriate for gestational age (AGA) as compared to those small for gestational age (SGA)

2013 ◽  
Vol 26 (16) ◽  
pp. 1610-1615 ◽  
Author(s):  
Valentina Bozzetti ◽  
Giuseppe Paterlini ◽  
Paola DeLorenzo ◽  
Valeria Meroni ◽  
Diego Gazzolo ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Appropriate For Gestational Age ◽  
Feeding Tolerance

Increased risk for early hypertriglyceridemia in small for gestational age preterm infants

2020 ◽  
Vol 179 (12) ◽  
pp. 1873-1879
Author(s):  
Shira Rabinowicz ◽  
Orly Levkovitz ◽  
Leah Leibovitch ◽  
Irit Schushan-Eisen ◽  
Iris Morag ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Increased Risk

The Development of Communication in Preterm Infant-Mother Dyads

Behaviour ◽  
1994 ◽  
Vol 129 (1-2) ◽  
pp. 35-61 ◽  
Author(s):  
Y. van BEEK ◽  
J.B. Hoeksma ◽  
B. Hopkins
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Low Birthweight ◽  
Common Finding ◽  
Maternal Behaviour ◽  
Face To Face ◽  
Appropriate For Gestational Age ◽  
Lower Variability ◽  
Log Linear

AbstractThe present study examines the effects of gestational age and birthweight status on the development of infant and maternal behaviour as well as the (mutual) predictability between partners during face-to-face interaction at 6, 12 and 18 weeks of corrected age. Subjects are healthy fullterm infants (N = 6) and three groups of healthy preterm infants: small-for-gestational age (N = 6), and appropriate for gestational age, the latter being born after a pregnancy duration of less than 32 weeks (N = 6) or between 32 and 34 weeks (N = 6). Using dyadic sequential analyses, based on log-linear modelling and information statistics, for each individual infant-mother pair at each age, the effect of both partners on the behaviour of the other was quantified, while accounting for autocorrelational effects. In the majority of cases the interactions could be labelled as showing 'bidirectionality', particularly at 18 weeks. Mothers were more likely to be influenced by the previous behaviour of the infants than vice versa. No group differences were apparent in the way mothers were influenced by their infants. However, the small-for-gestational age preterm infants were less likely to be influenced by maternal behaviour, particularly at 6 and 12 weeks of age. A lower variability was the most common finding in infants who were not predictable from the previous behaviour of the mother. At 6 and 12 weeks they were less expressive and more often showed a monotonous behavioural pattern in which 'looking at mother's face without positive expressions' was shown during most of the interaction. As this lack of variability was more often found in SGA preterm infants, they were less predictable from their mother's behaviour than the fullterm and AGA preterm infants. These data suggest that having a low birthweight for gestational age may be a risk factor for a lack of 'bidirectionality' during early mother-infant interaction.

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