scholarly journals Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.

Gut ◽  
1993 ◽  
Vol 34 (10) ◽  
pp. 1315-1318 ◽  
Author(s):  
I Biemond ◽  
J Kreuning ◽  
J B Jansen ◽  
C B Lamers
Keyword(s):  
Diagnostic Value ◽  
Serum Pepsinogen ◽  
Serum Concentrations ◽  
Pepsinogen C ◽  
Pepsinogen A

scholarly journals Polyclonal pancreatic elastase assay is superior to monoclonal assay for diagnosis of acute pancreatitis

1997 ◽  
Vol 43 (12) ◽  
pp. 2339-2344 ◽  
Author(s):  
Volker Keim ◽  
Niels Teich ◽  
Andrea Reich ◽  
Fritz Fiedler ◽  
Joachim Mössner
Keyword(s):  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Polyclonal Antibodies ◽  
Roc Curves ◽  
Diagnostic Value ◽  
Serum Concentrations ◽  
Clinical Value ◽  
Serum Samples ◽  
Pancreatic Elastase ◽  
Serum Elisa

Abstract We compared the clinical values for diagnosis of acute pancreatitis of two commercial assays for pancreatic elastase: an ELISA procedure with monoclonal antibodies and a RIA technique with polyclonal antibodies. In 14 patients with acute pancreatitis, serum concentrations of elastase determined by ELISA (ELISA-elastase) decreased much faster (half-life 0.4 days) than those of elastase determined by RIA (RIA-elastase) (2.2 days), amylase (0.8 days), or lipase (0.9 days). Serum samples from 253 additional patients with abdominal pain (32 of these with acute pancreatitis) were analyzed. In sera collected up to 48 h after the onset of disease, the ROC curves showed a slightly higher diagnostic value of RIA-elastase. In samples taken later, at a sensitivity of 90% the specificity of RIA-elastase was 95% (ELISA-elastase 40%). We conclude that serum ELISA-elastase is of much lower clinical value than RIA-elastase for diagnosis of acute pancreatitis.

scholarly journals Effects of Pepsinogen C Gene Polymorphisms on Serum Pepsinogen I and Serum Pepsinogen II Levels.

1995 ◽  
Vol 49 (6) ◽  
pp. 998-1003
Author(s):  
Zentaro YAMAGATA ◽  
Sumio IIJIMA ◽  
Akio ASAKA ◽  
Kazuhisa KOBAYASHI
Keyword(s):  
Gene Polymorphisms ◽  
Serum Pepsinogen ◽  
Pepsinogen I ◽  
Pepsinogen C ◽  
Pepsinogen Ii

Tubular reabsorption of pepsinogen isozymogens in man studied by the inhibition of tubular protein reabsorption with dibasic amino acids

1991 ◽  
Vol 80 (2) ◽  
pp. 161-166 ◽  
Author(s):  
M. A. G. J. ten Dam ◽  
A. Zwiers ◽  
J. B. A. Crusius ◽  
G. Pals ◽  
G. J. van Kamp ◽  
...  
Keyword(s):  
Body Weight ◽  
Specific Binding ◽  
Tubular Reabsorption ◽  
Radioisotope Method ◽  
Pepsinogen C ◽  
Pepsinogen A ◽  
Fractional Clearance ◽  
Arginine Hydrochloride ◽  
Identical Amino Acid Sequence ◽  
Protein Reabsorption

1. The fractional clearances of pepsinogen A (PGA), pepsinogen C (PGC) and the main PGA isozymogens, i.e. PGA-3, PGA-4 and PGA-5, were measured in 13 healthy male volunteers before and during blockade of tubular protein reabsorption by intravenous infusion of either l-arginine hydrochloride (n = 8; 0.5 g h−1 kg−1 body weight) or an equimolar amount of l-lysine hydrochloride (n = 5; 0.44 g h−1 kg−1 body weight). Glomerular filtration rate was measured by a radioisotope method. 2. The fractional baseline clearance of PGC (1 ± 1%) was lower than that of PGA (20 ± 10%). In addition, the fractional clearance of the PGA isozymogens appeared to be different: the fractional clearance of PGA-5 (7 ± 3%) was lower than that of PGA-4 (18 ± 9%), and the fractional clearance of PGA-4 was lower than that of PGA-3 (30 ± 10%). These differences in fractional clearance between PGA isozymogens decreased during infusion of both arginine and lysine. 3. Pepsinogens are freely filtered proteins. It can therefore be concluded that the differences in fractional clearance between PGA isozymogens imply differences in tubular reabsorption. This is remarkable as PGA isozymogens are proteins with an almost identical amino acid sequence and electric charge. The disappearance of the differences in tubular reabsorption during arginine and lysine infusion suggests that PGA isozymogens differ in affinity for negatively charged binding sites in the tubular cell membrane. In order to explain the low fractional clearance of PGC compared with that of PGA and the less marked effect of arginine or lysine infusion on the fractional clearance of PGC, an additional PGC-specific binding site has to be postulated.

Effect of omeprazole and lansoprazole on serum pepsinogen A levels in patients with duodenal ulcer

1995 ◽  
Vol 56 (9) ◽  
pp. 887-893 ◽  
Author(s):  
Full-Young Chang ◽  
Chi-Teh Lee ◽  
Cheng-Yi Chiang ◽  
Shou-Dong Lee
Keyword(s):  
Duodenal Ulcer ◽  
Serum Pepsinogen ◽  
Pepsinogen A

Serum pepsinogen C: A useful marker of Helicobacter pylori eradication?

1996 ◽  
Vol 10 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Mario Plebani ◽  
Daniela Basso ◽  
Marina Scrigner ◽  
Andrea Toma ◽  
Francesco Di Mario ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Serum Pepsinogen ◽  
Helicobacter Pylori Eradication ◽  
Pepsinogen C

scholarly journals The diagnostic value of serum concentrations of 2-(α-mannopyranosyl)-l-tryptophan for normal renal function

2004 ◽  
Vol 65 (4) ◽  
pp. 1395-1399 ◽  
Author(s):  
Katsuhiko Yonemura ◽  
Reiko Takahira ◽  
Osamu Yonekawa ◽  
Naohiro Wada ◽  
Akira Hishida
Keyword(s):  
Renal Function ◽  
Normal Renal Function ◽  
Diagnostic Value ◽  
Serum Concentrations

scholarly journals Serum Dihydropyrimidinase-Like 3 Concentration in Patients with Gastric Cancer and Its Diagnostic Value

2021 ◽  
Author(s):  
Huiqiu Zhong ◽  
Xiaojiang Luo
Keyword(s):  
Gastric Cancer ◽  
Diagnostic Value ◽  
Control Group ◽  
Case Group ◽  
Serum Concentrations ◽  
Medical College ◽  
Healthy Control ◽  
Serum Cea ◽  
Gastric Cancer Patients ◽  
Group Serum

Background: We aimed to investigate the serum concentration of dihydropyrimidinase-like 3 (DPYSL3) in patients with gastric cancer and its clinical significance. Methods: Seventy four patients with gastric cancer from Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, China from October 2018 to April 2019 were selected as the case group. Sixty patients with normal gastric mucosa or mild non-atrophic gastritis were selected as the control group. Serum DPYSL3, CA72-4 and CEA concentrations were measured in both groups. Results: The serum DPYSL3 concentration in the case group was significantly higher than that in the healthy control group (22.04±9.22 vs. 8.36±4.19 μg/L, P<0.001). The serum DPYSL3 concentration in patients with advanced gastric cancer was significantly higher than that in early gastric cancer (27.09±9.12 vs. 13.04±8.22 μg/L, P<0.01); serum DPYSL3 concentration was significantly correlated with tumor size, TNM stage and differentiation (P<0.05). When the cutoff value was 20.98 μg/L, the serum DPYSL3 concentration could differentiate the gastric cancer with ROCAUC 0.882 (95% CI: 0.828-0.937) with sensitivity and specificity of 75% and 94%, respectively. Serum CA72-4 concentration could differentiate the gastric cancer from health controls with ROCAUC 0.812 (95% CI: 0.734-0.834), serum CEA concentration could differentiate gastric cancer with ROCAUC 0.612 (95% CI: 0.534 ~ 0.634). The serum concentrations of DPYSL3, CA72-4 and CEA in gastric cancer patients were increased compared to health controls. Conclusion: Three serological markers have complementary diagnostic value for gastric cancer. Serum DPYSL3 is a new potential molecular marker for gastric cancer.

Serum concentrations of pepsinogen A in healthy dogs after food deprivation and after feeding

2003 ◽  
Vol 64 (9) ◽  
pp. 1146-1150 ◽  
Author(s):  
Jan S. Suchodolski ◽  
Jorg M. Steiner ◽  
Craig G. Ruaux ◽  
David A. Williams
Keyword(s):  
Food Deprivation ◽  
Serum Concentrations ◽  
Pepsinogen A ◽  
Healthy Dogs
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