THE RELATIONSHIP BETWEEN P2Y12 GENE POLYMORPHISMS AND CLOPIDOGREL RESISTANCE IN PATIENTS WITH CORONARY HEART DISEASE

Summary. In 168 male diabetics aged 40-64 years participating in the Whitehall Study, ten-year age adjusted mortality rates were significantly higher than in non-diabetics for all causes, coronary heart disease, all cardiovascular disease and, in addition, causes other than cardiovascular. Mortality rates were not significantly related to known duration of the diabetes. The predictive effects of several major mortality risk factors were similar in diabetics and non-diabetics. Excess mortality rates in the diabetics could not be attributed to differences in levels of blood pressure or any other of the major risk factors measured. Key words: diabetics; mortality rates; risk factors; coronary heart disease. There are many studies documenting higher mortality rates - particularly from cardiovascular disease -in diabetics compared with age and sex matched diabetics from the same population (see Jarrett et al. (1982) for review). However, there is sparse information relating potential risk factors to subsequent mortality within a diabetic population, information which might help to explain the increased mortality risk and also suggest preventive therapeutic approaches. In the Whitehall Study, a number of established diabetics participated in the screening programme and data on mortality rates up to ten years after screening are available. We present here a comparison of diabetics and non-diabetics in terms of relative mortality rates and the influence of conventional risk factors as well as an analysis of the relationship between duration of diabetes and mortality risk.

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Up-Beat UK: A programme of research into the relationship between coronary heart disease and depression in primary care patients

BMC Family Practice ◽

10.1186/1471-2296-12-38 ◽

2011 ◽

Vol 12 (1) ◽

Cited By ~ 19

Author(s):

André Tylee ◽

Mark Ashworth ◽

Elizabeth Barley ◽

June Brown ◽

John Chambers ◽

...

Keyword(s):

Primary Care ◽

Coronary Heart Disease ◽

Heart Disease ◽

Primary Care Patients ◽

The Relationship

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Renin-angiotensin system gene polymorphisms and premature coronary heart disease

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.3317/jraas.2005.005 ◽

2005 ◽

Vol 6 (1) ◽

pp. 38-42 ◽

Cited By ~ 35

Author(s):

Cevad Sekuri ◽

F Sirri Cam ◽

Ertugrul Ercan ◽

Istemihan Tengiz ◽

Abdi Sagcan ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Gene Polymorphisms ◽

Renin Angiotensin System ◽

Angiotensin System ◽

Renin Angiotensin ◽

Premature Coronary Heart Disease

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Insulin Resistance and the Relationship of a Dyslipidemia to Coronary Heart Disease

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.110.219055 ◽

2011 ◽

Vol 31 (5) ◽

pp. 1208-1214 ◽

Cited By ~ 52

Author(s):

Sander J. Robins ◽

Asya Lyass ◽

Justin P. Zachariah ◽

Joseph M. Massaro ◽

Ramachandran S. Vasan

Keyword(s):

Insulin Resistance ◽

Coronary Heart Disease ◽

Heart Disease ◽

Relationship Of ◽

The Relationship

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GW26-e0809 The Relationship between Urokinase-type Plasminogen Activator and Its Receptor and the Stenosis of the Coronary Artery in Patients with Coronary Heart Disease

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2015.06.521 ◽

2015 ◽

Vol 66 (16) ◽

pp. C135

Author(s):

Zhenda Zheng ◽

Cailian Cheng ◽

Lin Wu ◽

Dinghui Liu ◽

Zhiming Song ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Artery ◽

Plasminogen Activator ◽

Type Plasminogen Activator ◽

Urokinase Type Plasminogen Activator ◽

The Relationship

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Antioxidant potential of diet: Association between dietary antioxidant index and odds of coronary heart disease: A case-control study

Mediterranean Journal of Nutrition and Metabolism ◽

10.3233/mnm-211503 ◽

2021 ◽

pp. 1-13

Author(s):

Farhad Vahid ◽

Zahra Nasiri ◽

Amir Abbasnezhad ◽

Ezatollah Fazeli Moghadam

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Antioxidant Capacity ◽

Case Control Study ◽

Case Control ◽

P Value ◽

Dietary Antioxidants ◽

Dietary Antioxidant ◽

The Relationship ◽

Control Study

BACKGROUND: Oxidative stress and chronic inflammation are among the leading causes of coronary heart disease (CHD). Studies investigated the relationship between dietary antioxidants and the risk/odds of CHD, and contradictory results have been reported. Dietary antioxidant index (DAI) is a novel and reliable nutritional tool that examines the diet’s overall antioxidant capacity. Its validity was examined using serum total antioxidant capacity and malondialdehyde. OBJECTIVE: This study aimed to investigate the relationship between DAI score and odds of CHD. METHODS: In this incidence case-control study, 320 individuals with a definitive diagnosis of CHD and 320 participants without CHD or related risk factors attending the same hospitals/polyclinics were selected as the case and control groups. We estimated the DAI by summing up six standardized intakes of major dietary antioxidants, including manganese, vitamin E, A, C, selenium, and zinc. RESULTS: Modeling DAI categorized according to the median (–0.38), in multi-adjusted model showed a significant protective association with the odd of CHD (OR = 0.72; 95%CI:0.51–0.99, p-value = 0.05). Also, modeling DAI as a continuous variable in multi-adjusted models (OR = 0.94;95%CI:0.90–0.95; p-value = 0.01) showed significant results. CONCLUSION: Using the DAI to investigate the relationship between dietary antioxidants and CHD can show more realistic results than a single study of antioxidants.

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