Primary non-gestational choriocarcinoma of the uterine cervix

Growth of cell system (BeWo-cell line) derived from human gestational choriocarcinoma has been established and continuously maintained in-vitro. Furthermore, it is evident from the previous studies that this cell line has retained the physiological function of the placental trophoblasts, namely the synthesis of human chorionic gonadotrophil(HCG).The BeWo cells were relatively small and possessed single nuclei, thus indicating that this cell line consists exclusively of cytotrophoblasts. In some instances cells appeared widely separated and their lateral surfaces were provided with numerous microvilli (Fig.1).

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Comparison of Choriocarcinoma and Normal Placenta

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100065663 ◽

1971 ◽

Vol 29 ◽

pp. 324-325

Author(s):

John C. Garancis ◽

Roland A. Pattillo ◽

Robert O. Hussa ◽

Jon V. Straumfjord

Keyword(s):

Cell Lines ◽

Small Cells ◽

Tissue Cultures ◽

Glycogen Depletion ◽

Cell Surfaces ◽

Intercellular Spaces ◽

Concomitant Increase ◽

Gestational Choriocarcinoma ◽

Cytoplasmic Glycogen ◽

Normal Placenta

Two different cell lines (Be-Wo and Jar) of human gestational choriocarcinoma have been maintained in continuous tissue culture for a period of four and two years respectively without losing the ability to elaborate human chorionic gonadotropin (HCG). Tissue cultures, as revealed by electron microscopy, consisted of small cells with single nuclei. In some instances cell surfaces were provided with microvilli but more often the intercellular spaces were narrow and bridged by desmosomes. However, syncytium was not formed. Endoplasmic reticulum (ER) was poorly developed in both cell lines, except in some Be-Wo cells it was prominent. Golgi complex, lysosomes and numerous free ribosomes, as well as excessive cytoplasmic glycogen, were present in all cells (Fig. 1). Glycogen depletion and concomitant increase of ER were observed in many cells following a single dose of 10 ugm/ml of adrenalin added to medium (Fig. 2).

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Introducing a novel highly prognostic grading scheme based on tumor budding and cell nest size for squamous cell carcinoma of the uterine cervix

10.1055/s-0038-1671052 ◽

2018 ◽

Author(s):

M Jesinghaus ◽

J Strehl ◽

M Boxberg ◽

A Wenzel ◽

F Brühl ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Uterine Cervix ◽

Tumor Budding ◽

Nest Size

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Computed tomography of iliopsoas involvement in uterine cervix cancer

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1987.23.6.1038 ◽

1987 ◽

Vol 23 (6) ◽

pp. 1038

Author(s):

J U Chung ◽

B I Choi ◽

S H Kim ◽

M C Han ◽

C W Kim

Keyword(s):

Computed Tomography ◽

Uterine Cervix ◽

Cervix Cancer ◽

Uterine Cervix Cancer

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THE PITUITARY AND ADRENAL RESPONSES TO ADMINISTRATION OF OESTRIOL IN GONADECTOMIZED RATS

Acta Endocrinologica ◽

10.1530/acta.0.0380050 ◽

1961 ◽

Vol 38 (1) ◽

pp. 50-58 ◽

Cited By ~ 3

Author(s):

N. E. Borglin ◽

L. Bjersing

Keyword(s):

Pituitary Gland ◽

Adrenal Cortex ◽

Clinical Experience ◽

Uterine Cervix ◽

Morphological Changes ◽

Physiological Significance ◽

Female Rats ◽

Experimental Conditions ◽

Male And Female ◽

Male And Female Rats

ABSTRACT Oestriol (oestra-1,3,5(10)-triene-3,16α,17β-triol) is a weakly oestrogenic substance which, however, in contrast to what was formerly believed, is of physiological significance. Its effect is localized largely to the uterine cervix and vagina. Clinical experience argues both for and against an effect on the pituitary gland. This investigation is concerned with the morphological changes in the pituitary gland and adrenal cortex of gonadectomized male and female rats after the injection of oestriol. It was found that oestriol has the same type of action on these glands as other oestrogens, but under the experimental conditions used, this effect proved much weaker than that produced by oestradiol (oestra-1,3,5(10)-triene-3,17β-diol).

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PROPRANOLOL-BLOCKADE OF VASOPRESSIN INDUCED INCREASE IN PLASMA PROGESTERONE IN EARLY HUMAN PREGNANCY

Acta Endocrinologica ◽

10.1530/acta.0.0660283 ◽

1971 ◽

Vol 66 (2) ◽

pp. 283-288 ◽

Cited By ~ 4

Author(s):

Petter Fylling

Keyword(s):

Cyclic Amp ◽

Uterine Cervix ◽

Adenosine Monophosphate ◽

First Trimester ◽

Blocking Agent ◽

Simultaneous Administration ◽

Plasma Progesterone ◽

Human Pregnancy ◽

Peripheral Plasma ◽

Early Human

ABSTRACT Following continuous dilation of the uterine cervix or intravenous infusion of vasopressin during the first trimester of human pregnancy, a marked increase in the peripheral plasma progesterone levels was observed. This effect was blocked by simultaneous administration of propranolol (Inderal®), a β-blocking agent. It is suggested that both these stimulating and inhibiting effects might be related to 3′, 5′-adenosine monophosphate (cyclic AMP). The results indicate the existence of β-receptors in steroid producing tissues.

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