Logopenic aphasia in Alzheimer's disease: clinical variant or clinical feature?

2012 ◽  
Vol 83 (11) ◽  
pp. 1056-1062 ◽  
Author(s):  
Samrah Ahmed ◽  
Celeste A de Jager ◽  
Anne-Marie F Haigh ◽  
Peter Garrard
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Feature ◽  
Clinical Variant ◽  
Logopenic Aphasia

O4-04-03: Logopenic aphasia in Alzheimer's disease: Clinical variant or clinical feature?

2012 ◽  
Vol 8 (4S_Part_17) ◽  
pp. P621-P622
Author(s):  
Samrah Ahmed ◽  
Celeste de Jager ◽  
Anne-Marie Haigh ◽  
Peter Garrard
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Feature ◽  
Clinical Variant ◽  
Logopenic Aphasia

Clinical Characteristic in Primary Progressive Aphasia in Relation to Alzheimer’s Disease Biomarkers

2021 ◽  
pp. 1-13
Author(s):  
Sung Hoon Kang ◽  
Hanna Cho ◽  
Jiho Shin ◽  
Hang-Rai Kim ◽  
Young Noh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Language Impairment ◽  
Amyloid Β ◽  
Primary Progressive Aphasia ◽  
Cortical Atrophy ◽  
Clinical Feature ◽  
Progressive Aphasia ◽  
Disease Biomarkers ◽  
Primary Progressive

Background: Primary progressive aphasia (PPA) is associated with amyloid-β (Aβ) pathology. However, clinical feature of PPA based on Aβ positivity remains unclear. Objective: We aimed to assess the prevalence of Aβ positivity in patients with PPA and compare the clinical characteristics of patients with Aβ-positive (A+) and Aβ-negative (A–) PPA. Further, we applied Aβ and tau classification system (AT system) in patients with PPA for whom additional information of in vivo tau biomarker was available. Methods: We recruited 110 patients with PPA (41 semantic [svPPA], 27 non-fluent [nfvPPA], 32 logopenic [lvPPA], and 10 unclassified [ucPPA]) who underwent Aβ-PET imaging at multi centers. The extent of language impairment and cortical atrophy were compared between the A+ and A–PPA subgroups using general linear models. Results: The prevalence of Aβ positivity was highest in patients with lvPPA (81.3%), followed by ucPPA (60.0%), nfvPPA (18.5%), and svPPA (9.8%). The A+ PPA subgroup manifested cortical atrophy mainly in the left superior temporal/inferior parietal regions and had lower repetition scores compared to the A–PPA subgroup. Further, we observed that more than 90%(13/14) of the patients with A+ PPA had tau deposition. Conclusion: Our findings will help clinicians understand the patterns of language impairment and cortical atrophy in patients with PPA based on Aβ deposition. Considering that most of the A+ PPA patents are tau positive, understanding the influence of Alzheimer’s disease biomarkers on PPA might provide an opportunity for these patients to participate in clinical trials aimed for treating atypical Alzheimer’s disease.

scholarly journals The linguistic impairment of the perfect aspect in Alzheimer’s disease and logopenic primary progressive aphasia

2021 ◽  
Vol 2 (4) ◽  
pp. e528
Author(s):  
Jean Carlos da Silva Gomes ◽  
Adriana Leitão Martins ◽  
Fernanda de Carvalho Rodrigues
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Decline ◽  
Primary Progressive Aphasia ◽  
Recent Past ◽  
Primary Progressive ◽  
Syntactic Representation ◽  
Logopenic Aphasia ◽  
Present Tense ◽  
Linguistic Impairment

Taking into account that neuropsychological studies with subjects with language pathologies can contribute to the investigation of the organization of syntactic knowledge, the objective of this work is to investigate the syntactic representation of the perfect aspect based on data from subjects with pathologies that affect their language. More specifically, we aimed to investigate the possible phrases associated with the types of the perfect aspect and the hierarchy among them. This work aims to investigate the syntactic representation of the perfect aspect. Therefore, we sought to verify a possible linguistic impairment of this aspect in individuals diagnosed with Alzheimer's Disease (AD) and Primary Progressive Logopenic Aphasia (LPPA). A double case study was carried out with one patient with AD and another with LPPA. The methodology consisted of applying functionality tests, neuropsychological tests, and linguistic tests. The results indicated that both the AD patient and the LPPA patient present functional decline and cognitive impairment, with the degree of impairment of the first patient being more extensive than that of the second one in both cases. Regarding language, the patient with AD showed impairment with all four types of perfect, present tense, and imperfective aspect, whereas the LPPA patient has shown impairment only in perfect of recent past and present tense. Based on the results we propose the existence of a phrase to perfect of recent past and the dominance of the temporal phrase over the perfect phrases in the syntactic hierarchy.

Increase of EEG Alpha3/Alpha2 Power Ratio Detects Inferior Parietal Lobule Atrophy in Mild Cognitive Impairment

2018 ◽  
Vol 15 (5) ◽  
pp. 443-451
Author(s):  
Davide V. Moretti
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Feature ◽  
Power Ratio ◽  
Inferior Parietal Lobule ◽  
Mri Scans ◽  
Parietal Lobule ◽  
Early Alzheimer’S Disease

Objective: The inferior parietal lobule (IPL) has been implicate in many higher cognitive processes, as visuo-motor transformations, tool use or tool making. In subjects with mild cognitive impairment (MCI) at major risk to develop Alzheimer' Disease (AD) an impairment of subtle visuomotor or praxic abilities is a well-known clinical feature. Enhance of the ratio of EEG alpha3/alpha2 frequency power was detected in subjects with MCI who will transform in Alzheimer's disease (AD). Methods: We explored of the association of alpha3/alpha2 power ratio with cortical size of IPL in patients with MCI. 74 subjects with MCI undergone EEG recording and MRI scans. Alpha3/alpha2 power ratio in addition to cortical size had been computed for each patient. Three MCI groups had been acquired in keeping with growing tertile values of alpha3/alpha2 ratio. Huge difference of cortical thickness among the groups was calculated. Higher alpha3/alpha2 power ratio group had broader cortical loss compared to other teams on the IPL, particularly in the Supramarginal Gyrus, and Precuneus on both hemispheres. Results: Our results unveil the possible part that the IPL could play in determining the classic alterations of early Alzheimer's disease (AD). Conclusion: Finally, the rise of alpha3/alpha2 power ratio detected a focused anatomo-functional association that could be a reliable marker of incipient AD.

scholarly journals Random forest model for feature-based Alzheimer’s disease conversion prediction from early mild cognitive impairment subjects

2020 ◽  
Author(s):  
Matthew Velazquez ◽  
Yugyung Lee ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Random Forest ◽  
Clinical Features ◽  
Random Forest Model ◽  
Clinical Feature ◽  
Forest Model ◽  
Early Mild Cognitive Impairment

AbstractAlzheimer’s Disease (AD) conversion prediction from the mild cognitive impairment (MCI) stage has been a difficult challenge. This study focuses on providing an individualized MCI to AD conversion prediction using a balanced random forest model that leverages clinical data. In order to do this, 383 Early Mild Cognitive Impairment (EMCI) patients were gathered from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Of these patients, 49 would eventually convert to AD (EMCI_C), whereas the remaining 335 did not convert (EMCI_NC). All of these patients were split into training and testing data sets with 95 patients reserved for testing. Nine clinical features were selected, comprised of a mix of demographic, brain volume, and cognitive testing variables. Oversampling was then performed in order to balance the initially imbalanced classes. Our results showed that a random forest model was effective (93.6% accuracy) at predicting the conversion of EMCI patients to AD based on these clinical features. Additionally, we assessed the importance of each clinical feature at both the individual and model level for interpretation of the prediction itself. Our model could impact the clinical environment as a tool to predict the conversion to AD from a prodromal stage or to identify ideal candidates for clinical trials.

Deciphering Alzheimer’s Disease Pathogenic Pathway: Role of Chronic Brain Hypoperfusion on p-Tau and mTOR

2021 ◽  
Vol 79 (4) ◽  
pp. 1381-1396
Author(s):  
Jack C. de la Torre
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging ◽  
Memory Function ◽  
Mammalian Target Of Rapamycin ◽  
Tau Phosphorylation ◽  
Clinical Feature ◽  
Fast Axonal Transport ◽  
Current Topic

This review examines new biomolecular findings that lend support to the hemodynamic role played by chronic brain hypoperfusion (CBH) in driving a pathway to Alzheimer’s disease (AD). CBH is a common clinical feature of AD and the current topic of intense investigation in AD models. CBH is also the basis for the vascular hypothesis of AD which we originally proposed in 1993. New biomolecular findings reveal the interplay of CBH in increasing tau phosphorylation (p-Tau) in the hippocampus and cortex of AD mice, damaging fast axonal transport, increasing signaling of mammalian target of rapamycin (mTOR), impairing learning-memory function, and promoting the formation of neurofibrillary tangles, a neuropathologic hallmark of AD. These pathologic elements have been singularly linked with neurodegeneration and AD but their abnormal, collective participation during brain aging have not been fully examined. The format for this review will provide a consolidated analysis of each pathologic phase contributing to cognitive decline and AD onset, summarized in nine chronological steps. These steps galvanize each factor’s active participation and contribution in constructing a biomolecular pathway to AD onset generated by CBH.

scholarly journals Logopenic aphasia or Alzheimer's disease: Different phases of the same disease?

2014 ◽  
Vol 8 (3) ◽  
pp. 302-307 ◽  
Author(s):  
Bárbara Costa Beber ◽  
Renata Kochhann ◽  
Bruna Matias da Silva ◽  
Marcia L. F. Chaves
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Diagnosis ◽  
Clinical Case ◽  
Primary Progressive Aphasia ◽  
Clinical Findings ◽  
Initial Symptom ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Logopenic Aphasia

The logopenic variant of Primary Progressive Aphasia, or logopenic aphasia, is a the most recently described variant of Primary Progressive Aphasia and also the least well defined. This variant can present clinical findings that are also common to Alzheimer's disease, given they both share the same cytopathologic findings. This article reports the clinical case of a patient for whom it proved difficult to define a clinical diagnosis, being split between the logopenic variant and Alzheimer's disease at different phases of the disease. Using this case as an example and drawing on the latest evidence from the literature on the logopenic variant, we postulate the hypothesis that this variant may present as an initial symptom of Alzheimer's disease in some atypical cases.

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