Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD

2018 ◽  
Vol 89 (9) ◽  
pp. 989-994 ◽  
Author(s):  
Tao Xie ◽  
Lisa Bloom ◽  
Mahesh Padmanaban ◽  
Breanna Bertacchi ◽  
Wenjun Kang ◽  
...  
Keyword(s):  
Rating Scale ◽  
Freezing Of Gait ◽  
Term Effect ◽  
Double Blind Study ◽  
Motor Symptoms ◽  
Swallowing Function ◽  
Long Term Effect ◽  
Swallowing Difficulty ◽  
Stimulation Of

ObjectiveTo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson’s disease (PD) who have FOG at the usual 130 Hz stimulation.MethodsThis is a prospective, sequence randomised, crossover, double-blind study. PD patients with medication refractory FOG at 130 Hz stimulation of the STN were randomised to the sequences of 130 Hz, 60 Hz or deep brain stimulation off to assess swallowing function (videofluoroscopic evaluation and swallowing questionnaire), FOG severity (stand–walk–sit test and FOG questionnaire) and motor function (Unified PD Rating Scale, Part III motor examination (UPDRS-III)) at initial visit (V1) and follow-up visit (V2, after being on 60 Hz stimulation for an average of 14.5 months), in their usual medications on state. The frequency of aspiration events, perceived swallowing difficulty and FOG severity at 60 Hz compared with 130 Hz stimulation at V2, and their corresponding changes at V2 compared with V1 at 60 Hz were set as primary outcomes, with similar comparisons in UPDRS-III and its subscores as secondary outcomes.ResultsAll 11 enrolled participants completed V1 and 10 completed V2. We found the benefits of 60 Hz stimulation compared with 130 Hz in reducing aspiration frequency, perceived swallowing difficulty, FOG severity, bradykinesia and overall axial and motor symptoms at V1 and persistent benefits on all of them except dysphagia at V2, with overall decreasing efficacy when comparing V2 to V1.ConclusionsThe 60 Hz stimulation, when compared with 130 Hz, has long-term benefits on reducing FOG, bradykinesia and overall axial and motor symptoms except dysphagia, although the overall benefits decrease with long-term use.Clinical trial registrationNCT02549859; Pre-results.

Long-term effect of high-intensity laser therapy for persistent shoulder pain: A case report

2020 ◽  
Vol 33 (6) ◽  
pp. 947-951
Author(s):  
Javier Aceituno-Gómez ◽  
Venancio Miguel García-Madero ◽  
Juan José Criado-Álvarez ◽  
Jaime González-González ◽  
Julio Gómez-Soriano ◽  
...  
Keyword(s):  
Case Report ◽  
Laser Therapy ◽  
Shoulder Pain ◽  
High Intensity ◽  
Rating Scale ◽  
Term Effect ◽  
Long Term Effect ◽  
High Intensity Laser ◽  
Intensity Laser

BACKGROUND AND OBJECTIVE: This case report describes the long-term effect of the high-intensity laser therapy (HILT) in a patient with chronic shoulder pain refractory in comparison to other treatments. CASE DESCRIPTION: Ten sessions of HILT were applied in a thirty-one-year-old woman diagnosed with subacromial syndrome. Assessment was carried out through different tests: Shoulder Pain and Disability Index (SPADI), Numeric Pain Rating Scale (NPRS) and pressure pain threshold (PPT). All measurements were taken at four different points: at the end of the 10 sessions, after one month, three months after the intervention and nine months after the initial intervention. RESULTS: There was a clinically significant improvement in NPRS (decrease of 5 points), PPT (increase of 1.5 kg/cm2) and SPADI (decrease of 24 points) one month after the intervention. After three months, the increase of NPRS and SPADI required a 5-session intervention to support the clinical improvement. Six months after these booster sessions an increase in PPT and a decrease in NPRS and SPADI were observed. CONCLUSION: Results indicate the suitability of developing new research lines which will optimize the use of HILT.

OBSERVATIONS ON SUCCESSIVE PRO-OESTROUS LH SURGES IN INDIVIDUAL 4-DAY CYCLING AND POST-PSEUDOPREGNANT RATS

1978 ◽  
Vol 88 (2) ◽  
pp. 274-284 ◽  
Author(s):  
Alberto J. Carrillo ◽  
Charles H. Sawyer
Keyword(s):  
Mechanical Stimulation ◽  
Term Effect ◽  
Oestrous Cycle ◽  
The Other ◽  
Peak Amplitude ◽  
Lh Surge ◽  
Long Term Effect ◽  
The Mean ◽  
Stimulation Of

ABSTRACT The internal variations (i. e. in timing, duration and amplitude) of the LH surge mechanism within individual rats were examined by monitoring from 3 to 7 successive pro-oestrous LH surges in each of 5 regular 4-day cycling rats fitted with chronic intravenous cannulas. On each successive pro-oestrus blood was collected (0.5–0.6 ml hourly from 14.00–21.00) for radioimmunoassay of LH. The surgery of cannulation had no long-term effect on the regularity of the oestrous cycle. Two rats did, however, show briefly irregular cycles, including one with a 9-day period of anoestrus (pseudopregnancy). In three of the five rats successive pro-oestrous plasma LH curves (4 in one and 3 each in the other two) were internally very consistent in timing, shape and amplitude, However, between each 2 of these 3 animals there were distinct differences in the LH secretory patterns, by as much as 2 h in timing of the onset of the surge and its peak amplitude. The first two surges of the other two rats were atypical of their subsequent surges, which were mostly consistent in timing and amplitude. The pro-oestrous LH surge following the 9-day period of anoestrus was advanced by 2 h and elevated to twice the mean peak amplitude of the cyclic LH surges in that rat. Subsequently, post-PSP surges were studied in rats made pseudopregnant by mechanical stimulation of the cervix. In all cases the immediate post-PSP surge occurred earlier in the afternoon and with a greater peak amplitude than the subsequent cyclic LH surge in the same rat.

Long-term effect of subthalamic nucleus deep brain stimulation on freezing of gait in Parkinson’s disease

2019 ◽  
Vol 131 (6) ◽  
pp. 1797-1804 ◽  
Author(s):  
Ryul Kim ◽  
Han-Joon Kim ◽  
Chaewon Shin ◽  
Hyeyoung Park ◽  
Aryun Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Freezing Of Gait ◽  
Term Effect ◽  
Stimulation Condition ◽  
Long Term Effect ◽  
Stn Dbs ◽  
Deep Brain

OBJECTIVESubthalamic nucleus deep brain stimulation (STN DBS) is effective against freezing of gait (FOG) in Parkinson’s disease (PD); however, whether this effect persists over the long term is debated. The aim of the current study was to investigate the long-term effect of STN DBS on FOG in patients with PD.METHODSData on 52 cases in which PD patients received bilateral STN DBS were obtained from a prospective registry. The authors blindly analyzed FOG incidence and its severity from the videotapes of a 5-m walking task at the baseline and at the 1-, 2-, and 5- or 7-year follow-up visits. They also compared the axial score from the Unified Parkinson’s Disease Rating Scale (UPDRS) part III, UPDRS part II (UPDRS-II) item 14, and the FOG questionnaire (FOG-Q). Postoperatively, video-based FOG analysis and the axial score were evaluated under 4 conditions (off-medication/off-stimulation, off-medication/on-stimulation, on-medication/off-stimulation, and on-medication/on-stimulation), and UPDRS-II item 14 and the FOG-Q score were evaluated under 2 conditions (off-medication/on-stimulation and on-medication/on-stimulation).RESULTSDuring the off-medication state, the on-stimulation condition improved FOG outcomes, except for video-based FOG severity, up to the last follow-up compared with the baseline. Video-based FOG outcomes and the axial score during the off-medication state were improved with the on-stimulation condition up to the last follow-up compared with the off-stimulation condition. During the on-medication state, the on-stimulation condition did not improve any FOG outcome compared with the baseline; however, it improved video-based FOG outcomes up to the 2-year follow-up and the axial score up to the last follow-up compared with the off-stimulation condition.CONCLUSIONSOur findings suggest that STN DBS has a long-term effect on FOG in the off-medication state. However, STN DBS did not show a long-term effect on FOG in the on-medication state, although it had a short-term effect until the 2-year follow-up.

scholarly journals Long-term effect of cyclic AMP on N-glycosylation is caused by an increase in the activity of the cis-prenyltransferase

1996 ◽  
Vol 316 (2) ◽  
pp. 575-581 ◽  
Author(s):  
Matthias KONRAD ◽  
Wolfgang E. MERZ
Keyword(s):  
Cyclic Amp ◽  
Kinase Activity ◽  
Fold Increase ◽  
Term Effect ◽  
Long Term Effect ◽  
Choriocarcinoma Cells ◽  
Specific Stimulation ◽  
Stimulation Of ◽  
In Cells

Previously we have shown that long-term pretreatment of JEG-3 choriocarcinoma cells with 8-bromo-cAMP increases the capacity for N-glycosylation that was caused by an 8–10-fold enlargement of the dolichol pyrophosphoryl oligosaccharide (Dol-PP-oligosaccharide) pool [Konrad and Merz (1994) J. Biol. Chem. 269, 8659–8666]. The factors involved in the effect of cAMP on synthesis of Dol-PP-oligosaccharide are investigated here. The GlcNAc transfer to dolichol phosphate (Dol-P) was found to be unaffected by pretreatment with 8-bromo-cAMP. By measuring the uptake of [3H]mevalonate, a 20-fold increase in the incorporation of the label into Dol-P was observed in the cells treated with 8-bromo-cAMP. Under the same conditions, the synthesis of dolichol was enhanced 60-fold. However, the incorporation of the radioactivity into cholesterol was not increased in the JEG-3 cells pretreated with 8-bromo-cAMP, which suggests a specific stimulation of the dolichol/Dol-P pathway by cAMP. The cis-prenyltransferase activity was found to be increased 10-fold in cells pretreated with 8-bromo-cAMP. Dolichol kinase activity was unaffected by stimulation with 8-bromo-cAMP. The present study suggests that the larger glycosylation capacity in JEG-3 cells treated with 8-bromo-cAMP is caused by an increase in the microsomal cis-prenyltransferase activity.

Long-term effect of robot-assisted treadmill walking reduces freezing of gait in Parkinson’s disease patients: a pilot study

2012 ◽  
Vol 260 (1) ◽  
pp. 296-298 ◽  
Author(s):  
Michael T. Barbe ◽  
Franka Cepuran ◽  
Martin Amarell ◽  
Eckhard Schoenau ◽  
Lars Timmermann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pilot Study ◽  
Freezing Of Gait ◽  
Term Effect ◽  
Treadmill Walking ◽  
Robot Assisted ◽  
Long Term Effect

scholarly journals Clinical Improvement After Treatment With IncobotulinumtoxinA (XEOMIN®) in Patients With Cervical Dystonia Resistant to Botulinum Toxin Preparations Containing Complexing Proteins

2021 ◽  
Vol 12 ◽  
Author(s):  
Harald Hefter ◽  
Christian J. Hartmann ◽  
Ulrike Kahlen ◽  
Sara Samadzadeh ◽  
Dietmar Rosenthal ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Botulinum Toxin ◽  
Cervical Dystonia ◽  
Neutralizing Antibodies ◽  
Rating Scale ◽  
Term Effect ◽  
Repeated Treatment ◽  
Long Term Effect

This study investigated the clinical long-term effect of incobotulinumtoxinA (incoBoNT/A) in 33 cervical dystonia (CD) patients who had developed partial secondary therapy failure (PSTF) under previous long-term botulinum toxin (BoNT) treatment. Patients were treated four times every 12 weeks with incoBoNT/A injections. Physicians assessed treatment efficacy using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) at the baseline visit, week 12 and 48. Patients rated quality of life of CD with the Craniocervical Dystonia Questionnaire (CDQ-24). Titres of neutralizing antibodies(NAB) were determined at start of the study and after 48 weeks. All patients had experienced significant and progressive worsening of symptoms in the last 6 months of previous BoNT treatment. Repeated incoBoNT/A injections resulted in a significant reduction in mean TWSTRS at week 12 and 48. Patients' rating of quality of life was highly correlated with TWSTRS but did not change significantly over 48 weeks. During the 48 weeks -period of incoBoNT/A treatment NAB titres decreased in 32.2%, did not change in 45.2%, and only increased in 22.6% of the patients. Thus, repeated treatment with the low dose of 200 MU incoBoNT/A over 48 weeks provided a beneficial clinical long-term effect in PSTF and did not booster titres of NAB.

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