OBSERVATIONS ON SUCCESSIVE PRO-OESTROUS LH SURGES IN INDIVIDUAL 4-DAY CYCLING AND POST-PSEUDOPREGNANT RATS

1978 ◽  
Vol 88 (2) ◽  
pp. 274-284 ◽  
Author(s):  
Alberto J. Carrillo ◽  
Charles H. Sawyer
Keyword(s):  
Mechanical Stimulation ◽  
Term Effect ◽  
Oestrous Cycle ◽  
The Other ◽  
Peak Amplitude ◽  
Lh Surge ◽  
Long Term Effect ◽  
The Mean ◽  
Stimulation Of

ABSTRACT The internal variations (i. e. in timing, duration and amplitude) of the LH surge mechanism within individual rats were examined by monitoring from 3 to 7 successive pro-oestrous LH surges in each of 5 regular 4-day cycling rats fitted with chronic intravenous cannulas. On each successive pro-oestrus blood was collected (0.5–0.6 ml hourly from 14.00–21.00) for radioimmunoassay of LH. The surgery of cannulation had no long-term effect on the regularity of the oestrous cycle. Two rats did, however, show briefly irregular cycles, including one with a 9-day period of anoestrus (pseudopregnancy). In three of the five rats successive pro-oestrous plasma LH curves (4 in one and 3 each in the other two) were internally very consistent in timing, shape and amplitude, However, between each 2 of these 3 animals there were distinct differences in the LH secretory patterns, by as much as 2 h in timing of the onset of the surge and its peak amplitude. The first two surges of the other two rats were atypical of their subsequent surges, which were mostly consistent in timing and amplitude. The pro-oestrous LH surge following the 9-day period of anoestrus was advanced by 2 h and elevated to twice the mean peak amplitude of the cyclic LH surges in that rat. Subsequently, post-PSP surges were studied in rats made pseudopregnant by mechanical stimulation of the cervix. In all cases the immediate post-PSP surge occurred earlier in the afternoon and with a greater peak amplitude than the subsequent cyclic LH surge in the same rat.

Polyacrilonytrile versus Cuprophan Membranes for Hemodialysis: Evaluation of Efficacy and Biocompatibility by Platelet Aggregation Studies

1981 ◽  
Vol 4 (5) ◽  
pp. 218-222 ◽  
Author(s):  
M. Berrettini ◽  
U. Buoncristiani ◽  
P. Parise ◽  
E. Ballatori ◽  
G.G. Nenci
Keyword(s):  
Platelet Count ◽  
Platelet Aggregation ◽  
Term Effect ◽  
The Other ◽  
Long Term Effect ◽  
Short And Long Term ◽  
Extracorporeal Dialysis ◽  
Uremic Patients

The short- and long-term effect of hemodialysis with two different membranes — cuprophan and polyacrilonytrile — on platelet aggregation has been investigated in 12 uremic patients undergoing extracorporeal dialysis, passing from one treatment to the other. Cuprophan membranes failed to correct the defective platelet aggregation of uremia, and their thrombogenicity was documented by a fall in platelet count and further impairment of platelet aggregation during dialysis. On the contrary, polyacrilonitryle membranes showed the capacity to correct completely but transiently the platelet aggregation, without changes in platelet count. The results indicate that polyacrilonytrile membranes show a better biocompatibility toward platelets than cuprophan membranes.

Long-term effect of natalizumab in patients with RRMS: TYSTEN cohort

2020 ◽  
pp. 135245852093623
Author(s):  
Kévin Bigaut ◽  
Thibaut Fabacher ◽  
Laurent Kremer ◽  
Jean-Claude Ongagna ◽  
Arnaud Kwiatkowski ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Activity ◽  
Predictive Factors ◽  
Term Effect ◽  
Cumulative Probability ◽  
Secondary Progressive ◽  
Long Term Effect ◽  
The Mean ◽  
Poor Outcomes

Background: Data are needed on long-term effect of natalizumab (NTZ) in relapsing-remitting multiple sclerosis (RRMS). Objectives: To evaluate the time of onset of secondary progressive phase in patients with an RRMS treated with NTZ and to investigate predictive factors. Methods: TYSTEN is an observational study. Patients starting NTZ between 2007 and 2012 were included and followed up until October 2018. Relapses, Expanded Disability Status Scale (EDSS) scores, and results of brain magnetic resonance imaging (MRI) were collected each year. Data were used to estimate the cumulative probability of several poor outcomes such as secondary progressive multiple sclerosis (SPMS) conversion, EDSS worsening, EDSS 4.0, and EDSS 6.0. Results: 770 patients were included. The mean follow-up duration was 97 months and the mean time exposure to NTZ was 66 months. At 10 years, the cumulative probability of SPMS was 27.7%. Predictive factors for poor outcomes were a ⩾1-point increase in EDSS score from baseline, new T2 lesion or T1 gadolinium-enhancing lesion, the occurrence of relapse at 1 or 2 years and No Evidence of Disease Activity (NEDA-3; no relapse, no new T2 or T1 gadolinium-enhancing lesions, no progression) was a protective factor. Conclusion: In our cohort of patients treated with NTZ, poor outcomes were infrequent and are driven by disease activity.

scholarly journals Long-term effect of cyclic AMP on N-glycosylation is caused by an increase in the activity of the cis-prenyltransferase

1996 ◽  
Vol 316 (2) ◽  
pp. 575-581 ◽  
Author(s):  
Matthias KONRAD ◽  
Wolfgang E. MERZ
Keyword(s):  
Cyclic Amp ◽  
Kinase Activity ◽  
Fold Increase ◽  
Term Effect ◽  
Long Term Effect ◽  
Choriocarcinoma Cells ◽  
Specific Stimulation ◽  
Stimulation Of ◽  
In Cells

Previously we have shown that long-term pretreatment of JEG-3 choriocarcinoma cells with 8-bromo-cAMP increases the capacity for N-glycosylation that was caused by an 8–10-fold enlargement of the dolichol pyrophosphoryl oligosaccharide (Dol-PP-oligosaccharide) pool [Konrad and Merz (1994) J. Biol. Chem. 269, 8659–8666]. The factors involved in the effect of cAMP on synthesis of Dol-PP-oligosaccharide are investigated here. The GlcNAc transfer to dolichol phosphate (Dol-P) was found to be unaffected by pretreatment with 8-bromo-cAMP. By measuring the uptake of [3H]mevalonate, a 20-fold increase in the incorporation of the label into Dol-P was observed in the cells treated with 8-bromo-cAMP. Under the same conditions, the synthesis of dolichol was enhanced 60-fold. However, the incorporation of the radioactivity into cholesterol was not increased in the JEG-3 cells pretreated with 8-bromo-cAMP, which suggests a specific stimulation of the dolichol/Dol-P pathway by cAMP. The cis-prenyltransferase activity was found to be increased 10-fold in cells pretreated with 8-bromo-cAMP. Dolichol kinase activity was unaffected by stimulation with 8-bromo-cAMP. The present study suggests that the larger glycosylation capacity in JEG-3 cells treated with 8-bromo-cAMP is caused by an increase in the microsomal cis-prenyltransferase activity.

Simulation of Particulates Resuspension from Human Walking in UFAD Room

2012 ◽  
Vol 170-173 ◽  
pp. 3639-3643 ◽  
Author(s):  
Can Li ◽  
Miao Shu Li ◽  
Xiang Xue Ma
Keyword(s):  
Indoor Air ◽  
Lagrangian Method ◽  
Term Effect ◽  
The Other ◽  
Human Walking ◽  
Air Distribution ◽  
Long Term Effect ◽  
Simulation Results ◽  
Model Room

In this study, the Lagrangian method is used simulate a process of particles resuspending from occupant walking and being carried away by exhaust in a under-floor air distribution (UFAD) room. Experiments are performed in the prototype of the model room, the results confirmed the particles concentration decay tendency. On the other hand, the numerical simulation results for time of decontaminate the particulates in indoor is agreement with the experimental results. It indicates that the Lagrangian method is suitable for calculate such a process. Based on these studies, the following conclusions can be obtained: (1) human walking cause the particles above 5μm increased rapidly by which resuspended into indoor air; (2) the particles can removaled by exhaust quickly, and it will not cause a long term effect.

Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD

2018 ◽  
Vol 89 (9) ◽  
pp. 989-994 ◽  
Author(s):  
Tao Xie ◽  
Lisa Bloom ◽  
Mahesh Padmanaban ◽  
Breanna Bertacchi ◽  
Wenjun Kang ◽  
...  
Keyword(s):  
Rating Scale ◽  
Freezing Of Gait ◽  
Term Effect ◽  
Double Blind Study ◽  
Motor Symptoms ◽  
Swallowing Function ◽  
Long Term Effect ◽  
Swallowing Difficulty ◽  
Stimulation Of

ObjectiveTo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson’s disease (PD) who have FOG at the usual 130 Hz stimulation.MethodsThis is a prospective, sequence randomised, crossover, double-blind study. PD patients with medication refractory FOG at 130 Hz stimulation of the STN were randomised to the sequences of 130 Hz, 60 Hz or deep brain stimulation off to assess swallowing function (videofluoroscopic evaluation and swallowing questionnaire), FOG severity (stand–walk–sit test and FOG questionnaire) and motor function (Unified PD Rating Scale, Part III motor examination (UPDRS-III)) at initial visit (V1) and follow-up visit (V2, after being on 60 Hz stimulation for an average of 14.5 months), in their usual medications on state. The frequency of aspiration events, perceived swallowing difficulty and FOG severity at 60 Hz compared with 130 Hz stimulation at V2, and their corresponding changes at V2 compared with V1 at 60 Hz were set as primary outcomes, with similar comparisons in UPDRS-III and its subscores as secondary outcomes.ResultsAll 11 enrolled participants completed V1 and 10 completed V2. We found the benefits of 60 Hz stimulation compared with 130 Hz in reducing aspiration frequency, perceived swallowing difficulty, FOG severity, bradykinesia and overall axial and motor symptoms at V1 and persistent benefits on all of them except dysphagia at V2, with overall decreasing efficacy when comparing V2 to V1.ConclusionsThe 60 Hz stimulation, when compared with 130 Hz, has long-term benefits on reducing FOG, bradykinesia and overall axial and motor symptoms except dysphagia, although the overall benefits decrease with long-term use.Clinical trial registrationNCT02549859; Pre-results.

scholarly journals The Touch of Intelligence

2021 ◽  
Vol 24 (4) ◽  
pp. 69-79
Author(s):  
Malcolm Ross
Keyword(s):  
Occupational Therapy ◽  
Ways Of Knowing ◽  
Term Effect ◽  
The Other ◽  
Art Practice ◽  
Effect Change ◽  
The Arts ◽  
Long Term Effect ◽  
The One

I have yet to be persuaded that what arts therapists are doing with their clients either actually counts as art—rather than an applied form of occupational therapy—or seems likely to have any long-term effect on easing their suffering, other than by distraction and temporary companionship. I don’t for a moment doubt the relevance of the arts, properly so called, for individual and collective wellbeing—one of the aims of this paper is to spell out what that might mean—butan art practice structured around the conventions of psychoanalysis seems to me entirely mistaken because, as a basis of legitimacy, it favours rationality and modelling over feeling and making good things.Rational, analytical ways of knowing are a direct contradiction to the intuitive and imaginative procedures of art, where touch rather than talk does all the work. The arts offer to effect change in the patient from within rather than from without, via empathetic attunement between the therapist and the patient rather by than argument and persuasion on the one hand or compliance on the other.

THE LONG-TERM EFFECT OF TRANSECTION OF THE PITUITARY STALK ON THE VOLUME OF THE PITUITARY GLAND OF THE ADULT GOAT

1966 ◽  
Vol 51 (3) ◽  
pp. 377-390 ◽  
Author(s):  
J. Hume Adams ◽  
Peter M. Daniel ◽  
M. L. Prichard
Keyword(s):  
Term Effect ◽  
Pituitary Stalk ◽  
Pars Intermedia ◽  
Pars Distalis ◽  
Long Term Effect ◽  
Severe Reduction ◽  
Pituitary Glands ◽  
The Mean ◽  
Parenchymal Cells

ABSTRACT A study was made of the changes in volume of the pituitary glands of adult female goats surviving for many weeks after pituitary stalk section. The mean volume of the whole gland was about one-third of that found in control goats of similar sex and age. Pars distalis shrank to one-fifth of the volume of the normal lobe. This shrinkage was due largely to contraction of the scar replacing the original massive infarct, but partly also to shrinkage of the surviving parenchymal cells. The infundibular process also showed a severe reduction in size. By contrast pars intermedia underwent a substantial hypertrophy.

Long-Term Effect of Different Optimizing Methods for Cardiac Resynchronization Therapy in Patients with Heart Failure: A Randomized and Controlled Pilot Study

Cardiology ◽  
2019 ◽  
Vol 142 (3) ◽  
pp. 158-166
Author(s):  
Yu  Zhang ◽  
Qiang  Xing ◽  
Jiang-Hua Zhang ◽  
Wei-Feng  Jiang ◽  
Mu  Qin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Resynchronization Therapy ◽  
Left Ventricular ◽  
Term Effect ◽  
The Other ◽  
Nominal Group ◽  
Cardiac Resynchronization ◽  
Resynchronization Therapy ◽  
Long Term Effect

Aim: During cardiac resynchronization therapy (CRT), optimized programming of the atrioventricular (AV) delay and ventricular-to-ventricular (VV) interval can lead to improved hemodynamics, symptomatic response, and left ventricular systolic function. Currently, however, there is no recommendation for the best optimization method. This study aimed to compare the long-term clinical outcomes of 4 different CRT optimization methods. Methods: One hundred and twenty-four consecutive CRT patients with severe heart failure and left bundle-branch block configuration were randomly assigned into four groups to undergo AV/VV delay optimization through echocardiogram (ECHO; n = 30), electrocardiogram (ECG; n = 32), QuickOpt algorithm (n = 28), and nominal AV/VV (n = 36) groups. Patients were followed up and underwent examinations, including New York Heart Association (NYHA) cardiac functional classification, 6-min walking distance (6MWD), and echocardiography, at 6, 12, 24, 36, and 48 months, respectively. The patients’ survival and clinical outcomes were compared among the four groups. Results: Kaplan-Meier survival analyses showed that the median survival was the same in the 4 groups: ECHO, 43 months; ECG, 44 months; QuickOpt, 44 months, and nominal, 41 months. At the 6-month follow-up, the reduction in left ventricular end diastolic diameter (LVEDD) was significantly less in the nominal group (–1.91 ± 2.58 mm) than that in the other three groups (ECHO: –3.70 ± 2.78 mm, p = 0.012; ECG: –3.53 ± 3.14 mm, p = 0.020; QuickOpt: –3.46 ± 2.65 mm, p = 0.032); 6MWD was significantly shorter in the nominal group (87.88 ± 34.76 m) than that in the other three groups (ECHO: 120.63 ± 56.93 m, p = 0.006; ECG: 114.97 ± 54.95 m, p = 0.020; QuickOpt: 114.57 ± 35.41 m, p = 0.027). Left ventricular ejection fraction (LVEF) significantly increased in ECHO (7.23 ± 2.76%, p = 0.010), ECG (8.50 ± 3.17%, p < 0.001), and QuickOpt (8.39 ± 2.90%, p < 0.001) compared with the nominal group (5.35 ± 2.59%). There were no significant differences among the groups in the aforementioned parameters at 24, 36, and 48 months, respectively. Conclusion: While LVEDD, LVEF, 6MWD, and NYHA were significantly improved in ECHO, ECG, and QuickOpt at 6 months, there were no significant improvements in any of the groups at 12, 24, and 48 months. These findings suggested that the long-term effect of the four CRT methods for heart failure was not significantly different.

scholarly journals The Long Term Effect of Elective Colpoperineoplasty on Sexual Function in the Reproductive Aged Women in Iran

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Safieh Jamali ◽  
Parvin Abedi ◽  
Athar Rasekh ◽  
Razieh Mohammadjafari
Keyword(s):  
Sexual Function ◽  
Prospective Observational Study ◽  
Term Effect ◽  
Reproductive Age ◽  
Repeated Measure ◽  
Long Term Effect ◽  
The Mean ◽  
Reproductive Aged Women ◽  
Vaginal Laxity

Objective. Many women are suffering from sexual dysfunction followed by vaginal laxity in their reproductive age. The aim of this study was to evaluate the long term effect of colpoperineoplasty on sexual function in Iranian reproductive aged women. Methods. This was a prospective observational study in which 79 women with vaginal laxity who were candidate for selective colpoperineoplasty in Jahrom, Iran, were recruited. Data on sexual function was collected via the Female Sexual Function (FSFI) questionnaire preoperatively, six months and 18 months after colpoperineoplasty. The paired t-test, Wilcoxon, Mann-Whitney, and Repeated Measure test were utilized for statistical purposes. Results. Seventy-six women completed the study by 18 months. The mean FSFI score changed from 24.19 ± 3.09 in baseline to 26.92 ± 3.41 after six months (P < 0.001); however dyspareunia and vaginal dryness were increased significantly. After 18 months all areas of sexual function including pain and lubrication improved significantly compared to the 6th month (P < 0.001). Sexual satisfaction was increased significantly six and 18 months after surgery (P < 0.001), and the total score of sexual function increased to 32.61 ± 1.32 after 18 months (P < 0.001). Conclusion. The long term effect of colpoperineoplasty in women who suffer from vaginal laxity is promising. It seems that patient’s dissatisfaction of sexual function can be a basis for colpoperineoplasty.

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