scholarly journals Effect of quartz and alumina dust on generation of superoxide radicals and hydrogen peroxide by alveolar macrophages, granulocytes, and monocytes.

1993 ◽  
Vol 50 (8) ◽  
pp. 732-735
Author(s):  
V A Gusev ◽  
Danilovskaja YeV ◽  
Vatolkina OYe ◽  
O S Lomonosova ◽  
B T Velichkovsky
Keyword(s):  
Hydrogen Peroxide ◽  
Alveolar Macrophages ◽  
Superoxide Radicals

Chemical and biochemical aspects of superoxide radicals and related species of activated oxygen

1982 ◽  
Vol 60 (11) ◽  
pp. 1330-1345 ◽  
Author(s):  
Ajit Singh
Keyword(s):  
Hydrogen Peroxide ◽  
Hydroxyl Radicals ◽  
Superoxide Radical ◽  
Superoxide Radicals ◽  
Living Systems ◽  
Biological Processes ◽  
Oxygen Species ◽  
Peroxy Radicals ◽  
Activated Oxygen ◽  
Oxygen Yield

The spectrum of biological processes in which oxygen is used by living systems is quite large, and the products include some damaging species of activated oxygen, particularly the superoxide radical [Formula: see text] and hydrogen peroxide (H2O2). Superoxide radicals and hydrogen peroxide, in turn, can lead to the formation of other damaging species: hydroxyl radicals (∙OH) and singlet oxygen (1O2). Hydroxyl radicals react with organic compounds to give secondary free radicals that, in the presence of oxygen, yield peroxy radicals, peroxides, and hydroperoxides. Formation, interconversion, and reactivity of [Formula: see text] and related activated oxygen species, methods available for their detection, and the basis of their biological toxicity are briefly reviewed.

Application of Chemiluminescent Probe to Monitoring Superoxide Radicals and Hydrogen Peroxide in TiO2Photocatalysis

1997 ◽  
Vol 101 (30) ◽  
pp. 5822-5827 ◽  
Author(s):  
Yoshio Nosaka ◽  
Yoshifumi Yamashita ◽  
Hiroshi Fukuyama
Keyword(s):  
Hydrogen Peroxide ◽  
Superoxide Radicals

Extracellular Release of Hydrogen Peroxide by Human Alveolar Macrophages: The Relationship to Cigarette Smoking and Lower Respiratory Tract Infections

1983 ◽  
Vol 65 (6) ◽  
pp. 661-664 ◽  
Author(s):  
A. P. Greening ◽  
D. B. Lowrie
Keyword(s):  
Hydrogen Peroxide ◽  
Respiratory Tract ◽  
Alveolar Macrophages ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Inflammatory Cells ◽  
Extracellular Release ◽  
Human Alveolar Macrophages ◽  
Tract Infections ◽  
The Relationship

1. It has been suggested that oxidants from pulmonary inflammatory cells may contribute to the development of emphysema by (i) direct tissue toxicity and (ii) inhibition of α1-antitrypsin, thus diminishing protection of the lung from proteolytic damage. 2. The extracellular release of hydrogen peroxide (H2O2) by human alveolar macrophages (AM) has been measured. AM were obtained by bronchoalveolar lavage and adherence from 24 smokers and 17 non-smokers. 3. Smokers' AM released significantly more H2O2 (3.83 nmol h−1 üg−1 of DNA; sem 0.44) than those of non-smokers' (2.33 nmolh−1 μg−1 of DNA; sem 0.40) (P <0.05). 4. AM from donors with a recent lower respiratory tract infection released increased quantities of H2O2 (5.22 nmol h−1 μg−1 of DNA; sem 0.72; P <0.01) even when allowance was made for smoking habits. 5. These findings are consistent with the hypothesis that H2O2 of AM origin contributes to the development of emphysema in smokers.

scholarly journals Ferrous ion-EDTA-stimulated phospholipid peroxidation. A reaction changing from alkoxyl-radical- to hydroxyl-radical-dependent initiation

1984 ◽  
Vol 224 (3) ◽  
pp. 697-701 ◽  
Author(s):  
J M C Gutteridge
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Hydroxyl Radical ◽  
Hydroxyl Radicals ◽  
Superoxide Radicals ◽  
Ferrous Ion ◽  
Radical Scavengers ◽  
Alkoxyl Radical ◽  
Phospholipid Peroxidation ◽  
Hydroxyl Radical Scavengers

The stimulatory effect of ferrous salts on the peroxidation of phospholipids can be enhanced by EDTA when the concentration of Fe2+ in the reaction is greater than that of EDTA. Hydroxyl-radical scavengers do not inhibit peroxidation until the concentrations of Fe2+ and EDTA in the reaction are equal. Lipid peroxidation is then substantially initiated by hydroxyl radicals derived from a Fenton-type reaction requiring hydrogen peroxide. Superoxide radicals appear to play some role in the formation of initiating species.

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