scholarly journals Prevalence of genital Chlamydia trachomatis infection in the general population of Slovenia: serious gaps in control

2004 ◽  
Vol 80 (2) ◽  
pp. 121-123 ◽  
Author(s):  
I Klavs
Keyword(s):  
Chlamydia Trachomatis ◽  
General Population ◽  
Chlamydia Trachomatis Infection

scholarly journals Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Pengcheng Huai ◽  
Furong Li ◽  
Tongsheng Chu ◽  
Dianchang Liu ◽  
Jian Liu ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
General Population ◽  
Meta Analysis ◽  
Chlamydia Trachomatis Infection

Reinfections, Persistent Infections, and New Infections After General Population Screening for Chlamydia trachomatis Infection in The Netherlands

2005 ◽  
Vol 32 (10) ◽  
pp. 599-604 ◽  
Author(s):  
Irene K. Veldhuijzen ◽  
Jan E. A. M. Van Bergen ◽  
Hannelore M. G??tz ◽  
Christian J. P. A. Hoebe ◽  
Servaas A. Morr?? ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
General Population ◽  
The Netherlands ◽  
Population Screening ◽  
Chlamydia Trachomatis Infection ◽  
Persistent Infections

Striking ethnic variations in the epidemiology of Chlamydia trachomatis in Haifa District, Israel, throughout the years 2001–2015

2017 ◽  
Vol 28 (14) ◽  
pp. 1389-1396
Author(s):  
Khalaf Kridin ◽  
Mogher Khamaisi ◽  
Shmuel Rishpon ◽  
Rami Grifat
Keyword(s):  
Chlamydia Trachomatis ◽  
General Population ◽  
Ethnic Group ◽  
Incidence Rate ◽  
Ethnic Groups ◽  
Extended Period ◽  
Sexual Practices ◽  
Age Group ◽  
Chlamydia Trachomatis Infection ◽  
Ethnic Variations

Our objectives were to examine trends in the incidence of chlamydia over an extended period and compare the epidemiology of the infection between two distinct ethnic groups in Israel: Jews and Arabs. We examined the incidence rate of Chlamydia trachomatis infection among residents of Haifa District, northern Israel from 2001 to 2015, by reviewing archives of the Department of Epidemiology, Ministry of Health. Notified cases were stratified by age group, gender, and ethnic group. The overall incidence rate of Chlamydia was 10.8 cases per 100,000 population per year. The annual rate increased dramatically from 5.1 per 100,000 population in 2001, to an all-time high of 18.5 cases per 100,000 population in 2015 (P < 0.001), representing an increase of 362.7%. The most affected age group was 25–34 years of age. The estimated rate among Jewish inhabitants was ninefold higher than among Arabs. Only 3% recurrent episodes of Chlamydia were registered. The prevalence of HIV positivity among Chlamydia-infected patients was similar to that of the general population. In conclusion, Chlamydia in Haifa has been continuously increasing since 2001 and the infection is much more prevalent among patients of Jewish ethnicity, mainly due to more hazardous sexual practices in this population.

scholarly journals Seroepidemiology of Chlamydia trachomatis Infection in the General Population of Northern China: The Jidong Community Cohort Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Jingwei Shui ◽  
Dongjie Xie ◽  
Jianhui Zhao ◽  
Cailing Ao ◽  
Hongqing Lin ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
General Population ◽  
Statistical Significance ◽  
Age Groups ◽  
Northern China ◽  
Estimating Equation ◽  
Chlamydia Trachomatis Infection ◽  
The People ◽  
Significant Difference ◽  
Education Levels

A longitudinal serological study to investigate the seropositive frequency, incidence, and antibody dynamics of Chlamydia trachomatis infection in the general population of China is urgently needed in order to optimize the strategies for surveillance and precise prevention of C. trachomatis infection. This longitudinal study enrolled 744 subjects aged 18–65 years from Jidong Community of Northern China from 2014 to 2018. Seropositive frequency, incidence, and reinfection of C. trachomatis were determined by detecting antibody against C. trachomatis Pgp3 using “in-house” luciferase immunosorbent assay (LISA). The dynamic of anti-Pgp3 antibody was analyzed using the Generalized Estimating Equation (GEE) model. The overall Pgp3 seropositive frequency among the 18–65-year-old population was 28.1% (95% CI 24.9–31.5), and significantly increased from 12.0% in those aged 18–29 years to 48.6% in the 60–65 years old. The seropositive frequency was slightly higher in women than in men (31.3% vs. 25.4%) without statistical significance. The C. trachomatis incidence and reinfection rate were 11 and 14 per 1,000 person-years, respectively, and showed no significant difference with respect to age, gender, ethnicity, marital status, and education levels. Furthermore, anti-Pgp3 antibody remained detectable in 93.3% (195/209) of the seropositive subjects during the 5 years of follow-up. The overall decay rate for anti-Pgp3 antibody for CT-infected persons was −0.123 Log2 RLU/year, which was dramatically slower than in CT new infection (−3.34 Log2 RLU/year) or reinfection (−1.1 Log2 RLU/year). In conclusion, at least one quarter of the people aged 18–65 years have been infected with C. trachomatis over their lifetime while all age groups are susceptible to C. trachomatis infection in the community of Northern China. Therefore, comprehensive prevention strategies are urgently needed.

Genital Chlamydia trachomatis infection in Australia: epidemiology and clinical implications

Sexual Health ◽  
2004 ◽  
Vol 1 (4) ◽  
pp. 189 ◽  
Author(s):  
Marcus Y. Chen ◽  
Basil Donovan
Keyword(s):  
Primary Care ◽  
Chlamydia Trachomatis ◽  
General Population ◽  
General Practitioners ◽  
Indigenous Australians ◽  
Clinical Implications ◽  
National Strategy ◽  
Selective Screening ◽  
Risk Of Infection ◽  
Chlamydia Trachomatis Infection

Over the last decade, notification rates for genital Chlamydia trachomatis infection in Australia have been rising progressively. While chlamydia is common and possibly increasing in the general population, heterosexual adolescents, indigenous Australians in remote settings, and homosexually active men are at particular risk of infection. Few studies are available on the extent of morbidity from chlamydia-associated diseases. Australia urgently needs a national strategy to control chlamydia, with widespread, selective screening as a key component. As general practitioners have an important role to play, we proffer guidelines for selective testing in primary care.

scholarly journals P3.026 Low Prevalence of Chlamydia Trachomatis Infection: Fact or Missed Diagnosis?

2013 ◽  
Vol 89 (Suppl 1) ◽  
pp. A156.1-A156
Author(s):  
T Bharara ◽  
D Rawat ◽  
P Bhalla ◽  
V K Garg ◽  
K Sardana ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Chlamydia Trachomatis Infection ◽  
Missed Diagnosis ◽  
Low Prevalence

scholarly journals Differential Regulation of Inflammatory Cytokine Secretion by Human Dendritic Cells upon Chlamydia trachomatis Infection

2004 ◽  
Vol 72 (12) ◽  
pp. 7231-7239 ◽  
Author(s):  
Ana Gervassi ◽  
Mark R. Alderson ◽  
Robert Suchland ◽  
Jean François Maisonneuve ◽  
Kenneth H. Grabstein ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Chlamydia Trachomatis ◽  
Wide Spectrum ◽  
Cytokine Secretion ◽  
Host Cells ◽  
Microbial Pathogens ◽  
Potential Contribution ◽  
Necrosis Factor Alpha ◽  
Chlamydia Trachomatis Infection ◽  
Tnf Α

ABSTRACT Chlamydia trachomatis is an obligate intracellular gram-negative bacterium responsible for a wide spectrum of diseases in humans. Both genital and ocular C. trachomatis infections are associated with tissue inflammation and pathology. Dendritic cells (DC) play an important role in both innate and adaptive immune responses to microbial pathogens and are a source of inflammatory cytokines. To determine the potential contribution of DC to the inflammatory process, human DC were infected with C. trachomatis serovar E or L2. Both C. trachomatis serovars were found to infect and replicate in DC. Upon infection, DC up-regulated the expression of costimulatory (B7-1) and cell adhesion (ICAM-1) molecules. Furthermore, chlamydial infection induced the secretion of interleukin-1β (IL-1β), IL-6, IL-8, IL-12p70, IL-18, and tumor necrosis factor alpha (TNF-α). The mechanisms involved in Chlamydia-induced IL-1β and IL-18 secretion differed from those of the other cytokines. Chlamydia-induced IL-1β and IL-18 secretion required infection with viable bacteria and was associated with the Chlamydia-induced activation of caspase-1 in infected host cells. In contrast, TNF-α and IL-6 secretion did not require that the Chlamydia be viable, suggesting that there are at least two mechanisms involved in the Chlamydia-induced cytokine secretion in DC. Interestingly, an antibody to Toll-like receptor 4 inhibited Chlamydia-induced IL-1β, IL-6, and TNF-α secretion. The data herein demonstrate that DC can be infected by human C. trachomatis serovars and that chlamydial components regulate the secretion of various cytokines in DC. Collectively, these data suggest that DC play a role in the inflammatory processes caused by chlamydial infections.

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