Disseminated gonococcal infection due to a  -lactamase-producing strain of Neisseria gonorrhoeae: a case report

Disseminated gonococcal infection (DGI) is an uncommon complication ofNeisseria gonorrhoeaeinfection, its manifestation varies from a classic arthritis-dermatitis syndrome to uncommon pyogenic infections of several organs. Herein, we reported atypical presentation of DGI with subcutaneous abscess of right knee, pyomyositis of right lower extremity, and subsequently complicated byEscherichia colipyomyositis. This infection responded to appropriate antimicrobial therapy and prompt surgical management with good clinical outcome.

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Meningitis secondary to disseminated gonococcal infection

BMJ Case Reports ◽

10.1136/bcr-2021-244895 ◽

2021 ◽

Vol 14 (9) ◽

pp. e244895

Author(s):

Kelsey S Suggs ◽

Emmanuel Tito ◽

Nirmal Muthukumarasamy ◽

Mark Schauer

Keyword(s):

Cerebrospinal Fluid ◽

Case Report ◽

Neisseria Gonorrhoeae ◽

Bacterial Growth ◽

Throat Swab ◽

Gonococcal Infection ◽

Neurological Sequelae

We report one of the unusual presentations of disseminated gonococcal infection. This case report describes a 24-year-old woman who presented with disseminated gonococcal infection manifesting as meningitis. Cerebrospinal fluid (CSF) and throat swab PCR were positive for Neisseria gonorrhoeae. Blood and CSF cultures were negative for bacterial growth. The patient was treated with a total of 14 days of intravenous ceftriaxone. She was discharged with no neurological sequelae.

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Combined ceftriaxone and high-level azithromycin resistant Neisseria gonorrhoeae infection in the UK: a case report

10.26226/morressier.5af060651dd164001d5ef261 ◽

2018 ◽

Author(s):

Monique Andersson

Keyword(s):

Case Report ◽

Neisseria Gonorrhoeae ◽

The Uk ◽

High Level

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Neonatal Conjunctivitis Caused by Neisseria cinerea: A Case of Mistaken Identity

Journal of the Pediatric Infectious Diseases Society ◽

10.1093/jpids/piy116 ◽

2018 ◽

Vol 8 (5) ◽

pp. 478-480 ◽

Cited By ~ 1

Author(s):

Theresa M Fiorito ◽

Asif Noor ◽

Rodger Silletti ◽

Leonard R Krilov

Keyword(s):

Neisseria Gonorrhoeae ◽

Gonococcal Infection ◽

Mistaken Identity ◽

Increased Risk ◽

Neonatal Conjunctivitis

AbstractWe report a case of a 3-day-old boy with Neisseria cinerea conjunctivitis, originally misidentified as Neisseria gonorrhoeae conjunctivitis. Neonates are at increased risk for disseminated gonococcal infection, and physicians should be cognizant of N cinerea and its potential to be mistaken for N gonorrhoeae.

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Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae

mSphere ◽

10.1128/msphere.00421-17 ◽

2018 ◽

Vol 3 (1) ◽

Cited By ~ 15

Author(s):

Yingru Liu ◽

Julianny Perez ◽

Laura A. Hammer ◽

Heather C. Gallagher ◽

Magdia De Jesus ◽

...

Keyword(s):

Neisseria Gonorrhoeae ◽

Reproductive Tract ◽

The United States ◽

Interleukin 12 ◽

Gonococcal Infection ◽

Cell Production ◽

True Incidence ◽

Increased Risk ◽

Tubal Factor ◽

Intravaginal Administration

Genital infection withNeisseria gonorrhoeae(gonorrhea) is a significant cause of reproductive tract morbidity in women, leading to pelvic inflammatory disease, tubal factor infertility, and increased risk for ectopic pregnancy. WHO estimates that 78 million new infections occur annually worldwide. In the United States, >350,000 cases are reported annually, but the true incidence is probably >800,000 cases/year. Increasing resistance to currently available antibiotics raises concern that gonorrhea might become untreatable. Infection does not induce a state of immune protection against reinfection. Previous studies have shown thatN. gonorrhoeaesuppresses the development of adaptive immune responses by mechanisms dependent on the regulatory cytokines TGF-β and IL-10. This study shows that intravaginal treatment of gonococcal infection in female mice with microencapsulated IL-12 induces persisting anamnestic immunity against reinfection withN. gonorrhoeae, even of antigenically diverse strains, dependent on T-cell production of IFN-γ and B-cell production of antibodies.

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Neisseria gonorrhoeae

Oxford Textbook of Medicine ◽

10.1093/med/9780198746690.003.0110 ◽

2020 ◽

pp. 1025-1032

Author(s):

Jackie Sherrard ◽

Magnus Unemo

Keyword(s):

Neisseria Gonorrhoeae ◽

Sexual Activity ◽

Antimicrobial Therapy ◽

Genital Tract ◽

Systemic Disease ◽

Gonococcal Infection ◽

Gram Negative ◽

Lower Genital Tract ◽

Direct Inoculation ◽

Sex With Men

Neisseria gonorrhoeae is a Gram-negative, intracellular diplococcus that is transmitted by direct inoculation of infected secretion from one mucosa to another. It primarily colonizes the columnar epithelium of lower genital tract, only occasionally spreading to the upper genital tract or causing systemic disease. Oropharyngeal and rectal infections are common in men who have sex with men but also occur in women. N. gonorrhoeae is almost exclusively transmitted by sexual activity. Oropharyngeal and rectal infections usually produce no symptoms; disseminated gonococcal infection is a comparatively benign bacteraemia affecting joints (particularly shoulder and knee) and skin; traditionally more common in women than men. The gonococcus has adapted rapidly to prevalent antimicrobial usage, leading to resistance to all antibiotics used for treatment, notably penicillins, fluoroquinolones, macrolides, tetracycline, and cephalosporins. This development has resulted in major concerns internationally and the introduction of international and national action/response plans as well as dual antimicrobial therapy.

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Disseminated Gonococcal Infection in Japan: A Case Report and Literature Review

Internal Medicine ◽

10.2169/internalmedicine.50.5586 ◽

2011 ◽

Vol 50 (18) ◽

pp. 2039-2043 ◽

Cited By ~ 21

Author(s):

Ai Suzaki ◽

Kentaro Hayashi ◽

Kotoko Kosuge ◽

Masayoshi Soma ◽

Satoshi Hayakawa

Keyword(s):

Case Report ◽

Literature Review ◽

Gonococcal Infection

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A case of gonococcal necrotising fasciitis

Sexual Health ◽

10.1071/sh14027 ◽

2014 ◽

Vol 11 (3) ◽

pp. 280

Author(s):

Kudzai Nzenza Kanhutu ◽

Denis D. Spelman ◽

Michael D. Weymouth

Keyword(s):

Intensive Care ◽

Case Report ◽

Multiple Organ Failure ◽

Organ Failure ◽

Antimicrobial Therapy ◽

Multiple Organ ◽

Necrotising Fasciitis ◽

Gonococcal Infection ◽

Intensive Care Stay ◽

Extended Course

This case report details the progress of a patient with severe disseminated gonococcal infection with associated necrotising fasciitis. His admission was punctuated by multiple surgical debridements and a prolonged intensive care stay due to multiple organ failure. An extended course of azithromycin-based antimicrobial therapy achieved a cure and the patient was eventually discharged home after 8 weeks. To our knowledge this is the first such case of histologically and microbiologically confirmed gonococcal necrotising fasciitis.

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