P15 Lung cancer multidisciplinary meeting – does the presence of emphysema on ct imaging correlate with obstructive spirometry or transfer factor?

Micro-computed tomography (micro-CT) is a promising novel medical imaging modality that allows for non-destructive volumetric imaging of surgical tissue specimens at high spatial resolution. The aim of this study is to provide a comprehensive assessment of the clinical applications of micro-CT for the tissue-based diagnosis of lung diseases. This scoping review was conducted in accordance with the PRISMA Extension for Scoping Reviews, aiming to include every clinical study reporting on micro-CT imaging of human lung tissues. A literature search yielded 570 candidate articles, out of which 37 were finally included in the review. Of the selected studies, 9 studies explored via micro-CT imaging the morphology and anatomy of normal human lung tissue; 21 studies investigated microanatomic pulmonary alterations due to obstructive or restrictive lung diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and cystic fibrosis; and 7 studies examined the utility of micro-CT imaging in assessing lung cancer lesions (n = 4) or in transplantation-related pulmonary alterations (n = 3). The selected studies reported that micro-CT could successfully detect several lung diseases providing three-dimensional images of greater detail and resolution than routine optical slide microscopy, and could additionally provide valuable volumetric insight in both restrictive and obstructive lung diseases. In conclusion, micro-CT-based volumetric measurements and qualitative evaluations of pulmonary tissue structures can be utilized for the clinical management of a variety of lung diseases. With micro-CT devices becoming more accessible, the technology has the potential to establish itself as a core diagnostic imaging modality in pathology and to enable integrated histopathologic and radiologic assessment of lung cancer and other lung diseases.

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Dynamic PET/CT Imaging of 68Ga-FAPI-04 in Chinese Subjects

Frontiers in Oncology ◽

10.3389/fonc.2021.651005 ◽

2021 ◽

Vol 11 ◽

Author(s):

Shuailiang Wang ◽

Xin Zhou ◽

Xiaoxia Xu ◽

Jin Ding ◽

Teli Liu ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Body Mass ◽

Fdg Pet ◽

Radiation Dosimetry ◽

Ct Imaging ◽

Lung Cancer Patients ◽

Pet Ct ◽

Fdg Pet Ct ◽

Chinese Subjects

This study aims to further explore dynamic 68Ga-FAPI-04 PET/CT imaging of healthy Chinese subjects and lung cancer patients. Moreover, the variability of 68Ga-FAPI-04 uptake in normal organs was measured to provide a basis for analyzing its biological distribution, interpreting auxiliary images, determining the reliability of image quantification, and monitoring treatment. Six patients (3 subjects without tumors and 3 lung cancer patients) separately underwent 68Ga-FAPI-04 and 2-[18F]FDG PET/CT imaging within 1 week. The biodistribution and internal radiation dosimetry were reported and compared with data previously obtained from Caucasian patients. Moreover, the mean SUV (standardized uptake value) was normalized to body mass or to lean body mass (SUL), and the coefficients of variation (CVs) were calculated and compared for each volume of interest. The average whole-body effective dose was calculated to be 1.27E-02 mSv/MBq, which was comparable with previously reported results of 68Ga-FAPI-04 probes. Furthermore, the SUVmean was slightly higher than the SULmean in most organs; however, the CV of the SULmean for most organs was higher than that of the SUVmean at later time points. In the liver, the CV of the SUVmean was lower (12.7%) than that of the SULmean and was similar to the CV for corresponding 2-[18F]FDG PET/CT value (11.8%). In addition, 68Ga-FAPI-04 PET/CT showed good efficacy for diagnosing lung cancer patients in this study. A comparison of the radiation dosimetry obtained before from a Caucasian population demonstrated no clinically significant differences between these two populations after 68Ga-FAPI-04 injection. The variability in most organs was slightly lower for SUVmean than for SULmean, suggesting that SUVmean may be the preferable parameter for quantifying images obtained with 68Ga-FAPI-04. In addition, 68Ga-FAPI-04 PET/CT imaging is expected to be a promising tool for diagnosing lung cancer.

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PET/CT imaging in lung cancer: indications and findings

Jornal Brasileiro de Pneumologia ◽

10.1590/s1806-37132015000004479 ◽

2015 ◽

Vol 41 (3) ◽

pp. 264-274 ◽

Cited By ~ 26

Author(s):

Bruno Hochhegger ◽

Giordano Rafael Tronco Alves ◽

Klaus Loureiro Irion ◽

Carlos Cezar Fritscher ◽

Leandro Genehr Fritscher ◽

...

Keyword(s):

Lung Cancer ◽

Pulmonary Nodules ◽

Cancer Staging ◽

Ct Imaging ◽

Inappropriate Treatment ◽

Pet Ct ◽

Disease Staging ◽

Anatomical Information ◽

Work Up

The use of PET/CT imaging in the work-up and management of patients with lung cancer has greatly increased in recent decades. The ability to combine functional and anatomical information has equipped PET/CT to look into various aspects of lung cancer, allowing more precise disease staging and providing useful data during the characterization of indeterminate pulmonary nodules. In addition, the accuracy of PET/CT has been shown to be greater than is that of conventional modalities in some scenarios, making PET/CT a valuable noninvasive method for the investigation of lung cancer. However, the interpretation of PET/CT findings presents numerous pitfalls and potential confounders. Therefore, it is imperative for pulmonologists and radiologists to familiarize themselves with the most relevant indications for and limitations of PET/CT, seeking to protect their patients from unnecessary radiation exposure and inappropriate treatment. This review article aimed to summarize the basic principles, indications, cancer staging considerations, and future applications related to the use of PET/CT in lung cancer.

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Spectral CT Imaging of Lung Cancer

Academic Radiology ◽

10.1016/j.acra.2018.04.017 ◽

2018 ◽

Vol 25 (11) ◽

pp. 1398-1404 ◽

Cited By ~ 7

Author(s):

Feng Wu ◽

Hang Zhou ◽

Feng Li ◽

Jiang-tao Wang ◽

Tao Ai

Keyword(s):

Lung Cancer ◽

Ct Imaging ◽

Spectral Ct

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Radiolabeling, Characteristics and NanoSPECT/CT Imaging of 188Re-cetuximab in NCI-H292 Human Lung Cancer Xenografts

Anticancer Research ◽

10.21873/anticanres.13096 ◽

2018 ◽

Vol 39 (1) ◽

pp. 183-190 ◽

Cited By ~ 1

Author(s):

WAN-I KUO ◽

KAI-HUNG CHENG ◽

YA-JEN CHANG ◽

TSUNG-TSE WU ◽

WEI-CHUAN HSU ◽

...

Keyword(s):

Lung Cancer ◽

Human Lung ◽

Ct Imaging ◽

Human Lung Cancer

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PET/CT imaging in response evaluation of patients with small cell lung cancer

Lung Cancer ◽

10.1016/j.lungcan.2006.06.012 ◽

2006 ◽

Vol 54 (1) ◽

pp. 41-49 ◽

Cited By ~ 35

Author(s):

Barbara M. Fischer ◽

Jann Mortensen ◽

Seppo W. Langer ◽

Annika Loft ◽

Anne K. Berthelsen ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Ct Imaging ◽

Small Cell ◽

Response Evaluation ◽

Small Cell Lung ◽

Pet Ct

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Primary lung cancer and combined sparoganosis were suspected by multiple distant metastasis in PET–CT imaging of patient with colon cancer

Lung Cancer ◽

10.1016/j.lungcan.2012.05.084 ◽

2012 ◽

Vol 77 ◽

pp. S41-S42

Author(s):

Yoo Sang Yoon ◽

Soo Young Jung ◽

Youn Hee Choi ◽

Soon Hyo Park

Keyword(s):

Lung Cancer ◽

Colon Cancer ◽

Distant Metastasis ◽

Primary Lung Cancer ◽

Ct Imaging ◽

Pet Ct

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Etiology of Solitary Extrapulmonary Positron Emission Tomography and Computed Tomography Findings in Patients With Lung Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2005.10.116 ◽

2005 ◽

Vol 23 (28) ◽

pp. 6846-6853 ◽

Cited By ~ 87

Author(s):

Didier Lardinois ◽

Walter Weder ◽

Marina Roudas ◽

Gustav K. von Schulthess ◽

Michaela Tutic ◽

...

Keyword(s):

Computed Tomography ◽

Lung Cancer ◽

Positron Emission Tomography ◽

Ct Imaging ◽

Emission Tomography ◽

Whole Body ◽

Benign Tumors ◽

Positron Emission ◽

Pet Ct ◽

The Impact

Purpose The aim of this prospective study was to assess the incidence and the nature of solitary extrapulmonary [18F] fluorodeoxyglucose (FDG) accumulations in patients with non–small-cell lung cancer (NSCLC) staged with integrated positron emission tomography and computed tomography (PET/CT) and to evaluate the impact on management. Patients and Methods A total of 350 patients with NSCLC underwent whole-body PET/CT imaging. All solitary extrapulmonary FDG accumulations were evaluated by histopathology, further imaging, or clinical follow-up. Results PET/CT imaging revealed extrapulmonary lesions in 110 patients. In 72 patients (21%), solitary lesions were present. A diagnosis was obtained in 69 of these patients, including 37 (54%) with solitary metastases and 32 (46%) with lesions unrelated to the lung primary. Histopathologic examinations of these 32 lesions revealed a second clinically unsuspected malignancy or a recurrence of a previous diagnosed carcinoma in six patients (19%) and a benign tumor or inflammatory lesion in 26 patients (81%). The six malignancies consisted of carcinoma of the breast in two patients, and carcinoma of the orbit, esophagus, prostate, and non-Hodgkin's lymphoma in one patient each. Benign tumors and inflammatory lesions included eight colon adenomas, four Warthin's tumors, one granuloma of the lower jaw, one adenoma of the thyroid gland, one compensatory muscle activity due to vocal chord palsy, two occurrences of arthritis, three occurrences of reflux esophagitis, two occurrences of pancreatitis, two occurrences of diverticulitis, one hemorrhoidal inflammation, and one rib fracture. Conclusion Solitary extrapulmonary FDG accumulations in patients with newly diagnosed lung cancer should be analyzed critically for correct staging and optimal therapy, given that up to half of the lesions may represent unrelated malignancies or benign disease.

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