Neurophysiological evaluation of canine congenital hydrocephalus in three dogs

2020 ◽  
Vol 8 (1) ◽  
pp. e000949
Author(s):  
Mary Gutiérrez ◽  
Gimena Feijóo ◽  
Luis J Delucchi
Keyword(s):  
Auditory Evoked Potentials ◽  
Epileptiform Activity ◽  
Clinical Signs ◽  
Congenital Hydrocephalus ◽  
Bioelectrical Activity ◽  
Functional Changes ◽  
Sharp Waves ◽  
Clinical Responses ◽  
The Brain ◽  
Cerebrospinal Fluid Volume

Congenital hydrocephalus is a neurological disorder frequently observed in dogs. It is characterised by an increase of cerebrospinal fluid volume in the ventricular system that can cause atrophy of brain tissue. It can be provoked by diverse causes, as it can be idiopathic or secondary to nervous system abnormalities. Diagnosis is based on clinical signs and imaging studies, but neurophysiological techniques can provide valuable information. This report describes functional changes in the brain and brainstem evaluated by electroencephalogram and auditory evoked potentials. In the three cases, the authors found alterations in background rhythm, slow waves, epileptiform activity, hypsarrhythmic tracing and positive sharp waves. These techniques allow detecting alterations in the brain bioelectrical activity that do not trigger clear clinical responses.

CLINICAL AND ELECTROPHYSIOLOGICAL INDICATORS OF ACUTE AND EARLY RECOVERY PERIODS OF CEREBRAL STROKE

Vestnik ◽  
2021 ◽  
pp. 46-50
Author(s):  
Д.А. Митрохин ◽  
М.М. Ибрагимов ◽  
А.Н. Симбинова ◽  
Н.Ш. Буйракулова ◽  
В.В. Харченко ◽  
...  
Keyword(s):  
Practical Interest ◽  
Tension Headache ◽  
Haemorrhagic Stroke ◽  
Speech Disorders ◽  
Cerebral Stroke ◽  
Bioelectrical Activity ◽  
Early Recovery ◽  
Sharp Waves ◽  
Coherence Index ◽  
The Brain

В остром и раннем восстановительном периодах церебрального инсульта взаимосвязь между биоэлектрической активностью головного мозга и клинической картиной заболевания представляют значительный научный и практический интерес. В данной статье, представлены результаты исследования клинико-неврологических и электроэнцефалографических показателей, в остром и раннем восстановительном периодах церебрального инсульта, 67 больных в возрасте от 43 до 78 лет. Показано, что у больных в остром и раннем восстановительном периодах церебрального инсульта на фоне двигательных и речевых расстройств, наблюдались легкие и умеренные когнитивные нарушения, а также тревожно-депрессивные проявления. Головная боль, соответствующая критериям головной боли напряжения отмечалась у 61,1% больных. Биоэлектрическая активность головного мозга характеризовалась выраженной дельта и тета активностью, а также единичными острыми волнами, спайками, преимущественно в пораженном полушарии головного мозга, межполушарной асимметрией, повышением мощности спектров в сторону преобладания медленных волн. Показатели индекса когерентности по всем отведениям были снижены, что свидетельствует о нарушении функциональных межполушарных взаимосвязей. Более значительное повышение индекса когерентности в дельта и тета диапазонах у пациентов, перенесших геморрагический инсульт, может указывать на более грубые межполушарные нарушения, в сравнении с ишемическим инсультом. In the acute and early recovery periods of cerebral stroke, the correlation between bioelectrical activity of the brain and the clinical picture of the disease is of considerable scientific and practical interest. This article presents the results of a study of clinical, neurological and electroencephalographic parameters, in the acute and early recovery periods of cerebral stroke, in 67 patients aged from 43 to 78. Mild and moderate cognitive impairment as well as anxiety and depressive manifestations were shown among patients in the acute and early recovery periods of cerebral stroke amid the motor and speech disorders. Headache meeting the criteria of tension headache was reported among 61,1% of patients. The bioelectrical activity of the brain was characterised by marked delta and theta activity as well as single sharp waves, commissures mainly in the affected cerebral hemisphere, interhemispheric asymmetry and by increase in the spectrum power towards the predominance of slow waves. The coherence index scores were decreased on all directions, indicating impaired functional interhemispheric connectivity. A greater increase in coherence index in the delta and theta bands among haemorrhagic stroke patients may indicate more severe interhemispheric disturbances compared to ischaemic stroke.

scholarly journals High-frequency bioelectrical activity of the brain in the diagnosis of epilepsy

2018 ◽  
Vol 10 (3) ◽  
pp. 6-13 ◽  
Author(s):  
N. D. Sorokina ◽  
S. S. Pertsov ◽  
G. V. Selitsky
Keyword(s):  
High Frequency ◽  
Epileptiform Activity ◽  
Gamma Activity ◽  
Epileptic Focus ◽  
Bioelectrical Activity ◽  
Seizure Onset ◽  
High Frequency Oscillations ◽  
Gamma Rhythm ◽  
High Frequency Activity ◽  
The Brain

Recent studies show that the brain gamma activity includes both the gamma rhythm (standard EEG) and high frequency (100-1000 Hz) as well as super-high (>1000 Hz) frequency oscillations, as recorded by electrocorticography. As reported in the literature, the high-frequency oscillations (80-500 Hz) are highly informative markers of an epileptic focus. In this review, we analyze features of high-frequency activity associated with the epileptiform activity, and its relation to the seizure onset range. Further study of high-frequency bioelectric activity of the brain is of interest to researchers and clinicians, and may improve the EEG differential diagnosis of epilepsy.

Optical Monitoring of Neuronal Activity During Spontaneous Sharp Waves in Chronically Epileptic Human Neocortical Tissue

2000 ◽  
Vol 84 (4) ◽  
pp. 2161-2165 ◽  
Author(s):  
Rüdiger Köhling ◽  
Jörg-Michael Höhling ◽  
Heidrun Straub ◽  
Dieter Kuhlmann ◽  
Ulrich Kuhnt ◽  
...  
Keyword(s):  
Epileptiform Activity ◽  
Fast Imaging ◽  
Optical Monitoring ◽  
Field Potentials ◽  
Wide Spread ◽  
Paroxysmal Activity ◽  
Functional Changes ◽  
Sharp Waves ◽  
Spatially Inhomogeneous ◽  
Voltage Sensitive Dyes

Functional changes in neuronal circuitry reflected in spontaneously occurring synchronous sharp field potentials (SSFP) have been reported to occur in human brain suffering from chronic epileptogenicity but not in primary nonepileptic tissue from peritumoral resectates. Voltage sensitive dyes and fast imaging were used to visualize spontaneously occurring rhythmic depolarizations correlated to SSFP in chronically epileptic human neocortical slices obtained during epilepsy surgery. Localized and spatially inhomogeneous neuronal depolarizations were found to underlie spontaneous SSFP, which remained unchanged and spatially restricted to foci <750 μm diam even under epileptogenic (low-Mg2+) conditions. In cases where ictaform paroxysmal activity occurred in low-Mg2+medium, neuronal depolarizations were wide-spread but still spatially inhomogeneous, and the events were preferentially initiated at distinct foci. The findings suggest that small neuronal networks are able to establish and maintain synchronous rhythmic and epileptiform activity.

scholarly journals Efficacy of Intravenous Liposomal Amphotericin B (AmBisome) against Coccidioidal Meningitis in Rabbits

2002 ◽  
Vol 46 (8) ◽  
pp. 2420-2426 ◽  
Author(s):  
Karl V. Clemons ◽  
Raymond A. Sobel ◽  
Paul L. Williams ◽  
Demosthenes Pappagianis ◽  
David A. Stevens
Keyword(s):  
Spinal Cord ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
White Blood Cells ◽  
Clinical Signs ◽  
Liposomal Amphotericin B ◽  
Coccidioides Immitis ◽  
Lower Protein ◽  
Motor Abnormalities ◽  
The Brain

ABSTRACT The efficacy of intravenously administered liposomal amphotericin B (AmBisome [AmBi]) for the treatment of experimental coccidioidal meningitis was compared with those of oral fluconazole (FLC) and intravenously administered conventional amphotericin B (AMB). Male New Zealand White rabbits were infected by intracisternal inoculation of arthroconidia of Coccidioides immitis. Starting 5 days postinfection, animals received one of the following: 5% dextrose water diluent; AMB given at 1 mg/kg of body weight; AmBi given at 7.5, 15, or 22.5 mg/kg intravenously three times per week for 3 weeks; or oral FLC given at 80 mg/kg for 19 days. One week after the cessation of therapy, all survivors were euthanatized, the numbers of CFU remaining in the spinal cord and brain were determined, and histological analyses were performed. All AmBi-, FLC-, or AMB-treated animals survived and had prolonged lengths of survival compared with those for the controls (P < 0.0001). Treated groups had significantly lower numbers of white blood cells and significantly lower protein concentrations in the cerebrospinal fluid compared with those for the controls (P < 0.01 to 0.0005) and had fewer clinical signs of infection (e.g., weight loss, elevated temperature, and neurological abnormalities including motor abnormalities). The mean histological scores for AmBi-treated rabbits were lower than those for FLC-treated and control rabbits (P < 0.016 and 0.0005, respectively); the scores for AMB-treated animals were lower than those for the controls (P < 0.0005) but were similar to those for FLC-treated rabbits. All regimens reduced the numbers of CFU in the brain and spinal cord compared with those for the controls (P ≤0.0005). AmBi-treated animals had 3- to 11-fold lower numbers of CFU than FLC-treated rabbits and 6- to 35-fold lower numbers of CFU than AmB-treated rabbits. Three of eight animals given 15 mg of AmBi per kg had no detectable infection in either tissue, whereas other doses of AmBi or FLC cleared either the brain or the spinal cord of infection in fewer rabbits. In addition, clearance of the infection from both tissues was achieved in none of the rabbits, and neither tissue was cleared of infection in AMB-treated animals. Overall, these data indicate that intravenously administered AmBi is superior to oral FLC or intravenous AMB and that FLC is better than AMB against experimental coccidioidal meningitis. These data indicate that AmBi may offer an improvement in the treatment of coccidioidal meningitis. Additional studies are warranted.

scholarly journals L2HGDH Missense Variant in a Cat with L-2-Hydroxyglutaric Aciduria

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 682
Author(s):  
Matthias Christen ◽  
Nils Janzen ◽  
Anne Fraser ◽  
Adrian C. Sewell ◽  
Vidhya Jagannathan ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Genetic Defect ◽  
Clinical Signs ◽  
Missense Variant ◽  
Microcytic Anemia ◽  
Abnormal Behavior ◽  
Functional Candidate Gene ◽  
History Of ◽  
The Brain ◽  
Hydroxyglutaric Acid

A 7-month-old, spayed female, domestic longhair cat with L-2-hydroxyglutaric aciduria (L-2-HGA) was investigated. The aim of this study was to investigate the clinical signs, metabolic changes and underlying genetic defect. The owner of the cat reported a 4-month history of multiple paroxysmal seizure-like episodes, characterized by running around the house, often in circles, with abnormal behavior, bumping into obstacles, salivating and often urinating. The episodes were followed by a period of disorientation and inappetence. Neurological examination revealed an absent bilateral menace response. Routine blood work revealed mild microcytic anemia but biochemistry, ammonia, lactate and pre- and post-prandial bile acids were unremarkable. MRI of the brain identified multifocal, bilaterally symmetrical and T2-weighted hyperintensities within the prosencephalon, mesencephalon and metencephalon, primarily affecting the grey matter. Urinary organic acids identified highly increased levels of L-2-hydroxyglutaric acid. The cat was treated with the anticonvulsants levetiracetam and phenobarbitone and has been seizure-free for 16 months. We sequenced the genome of the affected cat and compared the data to 48 control genomes. L2HGDH, coding for L-2-hydroxyglutarate dehydrogenase, was investigated as the top functional candidate gene. This search revealed a single private protein-changing variant in the affected cat. The identified homozygous variant, XM_023255678.1:c.1301A>G, is predicted to result in an amino acid change in the L2HGDH protein, XP_023111446.1:p.His434Arg. The available clinical and biochemical data together with current knowledge about L2HGDH variants and their functional impact in humans and dogs allow us to classify the p.His434Arg variant as a causative variant for the observed neurological signs in this cat.

Experimental delayed radiation necrosis of the brain

1979 ◽  
Vol 51 (5) ◽  
pp. 587-596 ◽  
Author(s):  
Albert N. Martins ◽  
Ralph E. Severance ◽  
James M. Henry ◽  
Thomas F. Doyle
Keyword(s):  
Rhesus Monkeys ◽  
Radiation Necrosis ◽  
Clinical Signs ◽  
Control Group ◽  
Content Type ◽  
Brain Irradiation ◽  
Primate Brain ◽  
High Doses ◽  
The Brain ◽  
Male Rhesus

✓ The authors have designed an experiment to detect a hitherto unrecognized interaction between high doses of the glucocorticoid, dexamethasone, and brain irradiation. Eighteen juvenile male rhesus monkeys received 1800 rads to the whole brain in 8.5 minutes. For 1½ days before and 10½ days after the irradiation, nine animals received approximately 2.9 mg/kg/day of dexamethasone intramuscularly in addition to irradiation, while the remaining nine animals served as the control group and received saline. All animals eventually developed a progressive neurological syndrome, and died of delayed radiation necrosis of the brain. The two groups were compared with regard to latency to onset of clinical signs, survival time, and number, distribution, and location of lesions of radionecrosis. Large doses of dexamethasone did not alter the susceptibility of the primate brain to delayed radiation necrosis. Detailed morphological study of the radionecrotic lesions supports the hypothesis that most, if not all, of the lesions develop as the consequence of injury to blood vessels.

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