Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle
2015 ◽
Vol 40
(1)
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pp. 96-98
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Keyword(s):
Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.
2001 ◽
Vol 276
(14)
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pp. 10853-10860
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1998 ◽
Vol 83
(8)
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pp. 2830-2835
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2016 ◽
Vol 41
(8)
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pp. 856-863
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2004 ◽
Vol 24
(20)
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pp. 9079-9091
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2004 ◽
Vol 96
(6)
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pp. 2082-2087
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