scholarly journals Effectiveness of collagen supplementation on pain scores in healthy individuals with self-reported knee pain: a randomized controlled trial

2020 ◽  
Vol 45 (7) ◽  
pp. 793-800
Author(s):  
Coen C.W.G. Bongers ◽  
Dominique S.M. Ten Haaf ◽  
Milène Catoire ◽  
Bregina Kersten ◽  
Jeroen A. Wouters ◽  
...  
Keyword(s):  
Knee Pain ◽  
Controlled Trial ◽  
Middle Aged ◽  
Physically Active ◽  
P Values ◽  
Elderly Individuals ◽  
Collagen Peptide ◽  
Pain Scores ◽  
And Function ◽  
Similar Decrease

The purpose of this study was to examine the effects of 12 weeks collagen peptide (CP) supplementation on knee pain and function in individuals with self-reported knee pain. Healthy physically active individuals (n = 167; aged 63 [interquartile range = 56–68] years) with self-reported knee pain received 10 g/day of CP or placebo for 12 weeks. Knee pain and function were measured with the Visual Analog Scale (VAS), the Lysholm questionnaire, and the Knee injury and Osteoarthritis Outcome Score (KOOS). Furthermore, we assessed changes in inflammatory, cartilage, and bone (bio)markers. Measurements were conducted at baseline and after 12 weeks of supplementation. Baseline VAS did not differ between CP and placebo (4.7 [2.5–6.1] vs. 4.7 [2.8–6.2], p = 0.50), whereas a similar decrease in VAS was observed after supplementation (−1.6 ± 2.4 vs. −1.9 ± 2.6, p = 0.42). The KOOS and Lysholm scores increased after supplementation in both groups (p values < 0.001), whereas the increase in the KOOS and Lysholm scores did not differ between groups (p = 0.28 and p = 0.76, respectively). Furthermore, CP did not impact inflammatory, cartilage, and bone (bio)markers (p values > 0.05). A reduced knee pain and improved knee function were observed following supplementation, but changes were similar between groups. This suggests that CP supplementation over a 12-week period does not reduce knee pain in healthy, active, middle-aged to elderly individuals. Novelty CP supplementation over a 12-week period does not reduce knee pain in healthy, active, middle-aged to elderly individuals. CP supplementation over a 12-week period does not impact on inflammatory, cartilage, and bone (bio)markers in healthy, active, middle-aged to elderly individuals.

scholarly journals Knee Pain Patterns and Associations with Pain and Function in Persons with or at Risk for Symptomatic Radiographic Osteoarthritis: A Cross-sectional Analysis

2015 ◽  
Vol 42 (12) ◽  
pp. 2398-2403 ◽  
Author(s):  
Daniel L. Riddle ◽  
Mateusz Makowski
Keyword(s):  
Knee Pain ◽  
Cross Sectional ◽  
Knee Oa ◽  
Womac Function ◽  
Radiographic Osteoarthritis ◽  
Pain Location ◽  
Pain Scores ◽  
Patient Reported ◽  
And Function ◽  
Sectional Analysis

Objective.Knee pain location is routinely assessed in clinical practice. We determined the patterns of patient-reported pain locations for persons with knee osteoarthritis (OA). We also examined associations between knee pain patterns and severity of self-reported pain with activity and self-reported functional status.Methods.The Osteoarthritis Initiative data were used to examine reports of pain location (localized, regional, or global) and type and extent of knee OA. Multivariable ANCOVA models were used to determine associations between the Knee Injury and Osteoarthritis Outcome Survey (KOOS) Pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Function scales and pain location after adjusting for potential confounding. We also used radar graphs to illustrate pain patterns for various locations and severity of knee OA.Results.Radar graphs of 2696 knees indicated that pain pattern and location and extent of knee OA demonstrate substantial overlap. An interaction between race and pain location was found for WOMAC Function, but not for KOOS Pain scores. Global knee pain was associated (p < 0.001) with substantially worse function (by 6.5 points in African Americans) compared with pain that was localized. Knee pain reported as global was independently associated (p < 0.001) with clinically important lower (worse by 3.9 points) KOOS Pain scores compared with pain that was localized.Conclusion.Pain patterns are not useful for inferring potential location or severity of knee OA in individual patients, but knee pain patterns that are global are independently associated with worse pain and function compared with localized pain, and associations differ for function based on race.

scholarly journals Arthroscopic-assisted Latissimus Dorsi Tendon Transfer for the Management of Irreparable Rotator Cuff Tears in Middle-aged Physically Active Patients

2019 ◽  
Vol 22 (1) ◽  
pp. 9-15
Author(s):  
Tae Kang Lim ◽  
Kyu Hwan Bae
Keyword(s):  
Los Angeles ◽  
Rotator Cuff ◽  
Latissimus Dorsi ◽  
Tendon Transfer ◽  
Pain Scale ◽  
Rotator Cuff Tears ◽  
Middle Aged ◽  
Physically Active ◽  
And Function ◽  
Active Patients

Background: Latissimus dorsi (LD) tendon transfer is used as a treatment option for massive irreparable posterosuperior rotator cuff tears, and recently, an arthroscopic-assisted technique was introduced. This study was undertaken to evaluate the clinical and radiological outcomes of arthroscopic-assisted LD tendon transfer for the management of irreparable rotator cuff tears in active middle-aged patients.Methods: The records of five patients (two males) with irreparable tears involving the supraspinatus and infraspinatus tendons managed by arthroscopic-assisted LD tendon transfer were retrospectively reviewed. Clinical outcomes were assessed using the visual analogue scale (VAS) pain scale, American Shoulder and Elbow Surgeon’s (ASES) scores, the University of California Los Angeles (UCLA) scale, and ranges of motion. Postoperative integrities of transferred tendon were evaluated by magnetic resonance imaging in 4 patients and by ultrasound in one.Results: Mean patient age was 55 years (range, 48?61 years), and mean follow-up period was 20 months (range, 12.0?27.2 months). Mean VAS score significantly improved from 6.6 ± 2.6 preoperatively to 1.8 ± 2.5 postoperatively (<i>p</i>=0.009), mean ASES score increased from 67.6 ± 9.2 to 84.6 ± 15.1, and mean UCLA score from 18.0 ± 1.4 to 28.8 ± 8.5 (all <i>p</i><0.001). Postoperative imaging of the transferred LD tendon showed intact repair in 4 patients. The remaining patient experienced LD transfer rupture and a poor outcome.Conclusions: Arthroscopic-assisted LD tendon transfer improved shoulder pain and function in patients with massive, irreparable rotator cuff tears, and may be an option for this condition, especially in physically active patients.

scholarly journals POS1431 THE ASSOCIATION OF CLINICAL AND STRUCTURAL KNEE OSTEOARTHRITIS WITH PHYSICAL ACTIVITY IN THE MIDDLE-AGED POPULATION: THE NEO STUDY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 999.2-1000
Author(s):  
S. Terpstra ◽  
J. Van der Velde ◽  
R. De Mutsert ◽  
D. Schiphof ◽  
M. Reijnierse ◽  
...  
Keyword(s):  
Physical Activity ◽  
Knee Pain ◽  
Population Characteristics ◽  
Middle Aged ◽  
Knee Oa ◽  
Metabolic Equivalent Of Task ◽  
Related Quality ◽  
Health Related ◽  
Study Population ◽  
And Function

Background:Lack of physical activity in individuals with knee OA has shown to be associated with increased cardiovascular risk and mortality. Consequently, physical activity is a potential target for interventions in knee OA. However, most of the available studies concerning physical activity in individuals with knee OA were performed in relatively old populations with an inactive lifestyle. It is unclear how previous results can be generalized to other populations with different lifestyle and physical activity habits.Objectives:To investigate if knee OA is associated with lower physical activity in a general middle-aged Dutch population. Furthermore, to investigate the association of physical activity with patient reported outcomes such as knee pain and function, and health-related quality of life in individuals with knee OA.Methods:We used cross-sectional data from the Netherlands Epidemiology of Obesity (NEO) study, in which participants aged 45-65 years were included. Clinical knee OA was defined using the ACR criteria. Structural knee OA was defined on MRI using the modified criteria by Hunter et al. in a random subset of 1,285 individuals of our study population.We assessed knee pain and function with the Knee injury and Osteoarthritis Score (KOOS), and health-related quality of life (HRQoL) with the Short Form (SF)-36. Physical activity (in Metabolic Equivalent of Task (MET) hours per week) was assessed using the Short Questionnaire to Assess Health-enhancing physical activity (SQUASH).We used linear regression analyses to investigate 1) the association of knee OA with physical activity, and 2) of physical activity with knee pain, function, and HRQoL in participants with clinical knee OA. All analyses were adjusted for age, sex, body mass index (BMI), ethnicity, educational level and comorbidities. To account for possible information bias, we performed a sensitivity analysis to assess the association between clinical knee OA and physical activity measured by an accelerometer in a random subset of 15% of the study population.Results:Of 6,212 participants, we observed clinical knee OA in 14%, and structural knee OA in 12%. The general population characteristics and median physical activity of our study population are presented in Table 1. In comparison to participants without knee OA, participants with clinical knee OA had on average 9.60 (95% CI 3.70;15.50) MET hours per week more total physical activity (Figure 1). Structural knee OA was associated with 3.97 (-7.82; 15.76) MET hours per week more physical activity, compared with no structural knee OA.Sensitivity analysis showed a weak positive association of clinical knee OA with physical activity measured by an accelerometer: 2.37 (-6.05; 10.80) MET hours per week more physical activity in participants with clinical knee OA, compared with participants without clinical knee OA.In the subpopulation of participants with clinical knee OA, physical activity was not associated with knee pain, function or HRQoL.Conclusion:Knee OA was not associated with lower physical activity in this middle-aged Dutch population. This contrasts previous findings and warrants caution when generalizing physical activity outcomes to other populations. Furthermore, it stresses the need of more insight in the barriers and facilitators of physical activity in the middle-aged population.Table 1.Characteristics of the NEO study populationAlln = 6,214No clinical knee OA86%Clinical knee OA14%General population characteristics Age (year)55.7 (6.0)55.4 (6.1)57.5 (5.0) Sex (% women)555467 BMI (kg/m2)26.3 (4.4)26.1 (4.3)27.6 (5.1) Comorbidities (% present)242332Physical activity Total^ (MET-hours per week)118.8 (76.8;155.0)118.4 (76.6;154.4)123.5 (77.8;157.2)Numbers represent mean (SD) or percentages. ^median (25th, 75th percentiles). Abbreviations: OA = osteoarthritis. BMI = Body Mass Index. MET = Metabolic Equivalent of Task.Disclosure of Interests:None declared

Comparison of Protonics™ Knee Brace With Sport Cord on Knee Pain and Function in Patients With Patellofemoral Pain Syndrome: A Randomized Controlled Trial

2020 ◽  
Vol 29 (5) ◽  
pp. 547-554
Author(s):  
Mastour S. Alshaharani ◽  
Everett B. Lohman ◽  
Khaled Bahjri ◽  
Travis Harp ◽  
Mansoor Alameri ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Knee Pain ◽  
Controlled Trial ◽  
Pain Syndrome ◽  
Patellofemoral Pain Syndrome ◽  
Patellofemoral Pain ◽  
Global Rating ◽  
Knee Brace ◽  
Randomized Controlled ◽  
And Function

Context: Protonics™ knee brace has been suggested as an intervention for patients with patellofemoral pain syndrome. However, the effectiveness of this knee brace compared with traditional conservative methods knee rehabilitation is lacking. Objective: To compare the effect of Protonics™ knee brace versus sport cord on knee pain and function in patients with patellofemoral pain syndrome. Design: Randomized controlled trial. Setting: Loma Linda University. Participants: There were 41 subjects with patellofemoral pain with a mean age of 28.8 (5.0) years and body mass index of 25.6 (4.7) kg/m2 participated in the study. Intervention: Subjects were randomized to 1 of 2 treatment groups, the Protonics™ knee brace (n = 21) or the sport cord (n = 20) to complete a series of resistance exercises over the course of 4 weeks. Main Outcome Measures: Both groups were evaluated according to the following clinical outcomes: anterior pelvic tilt, hip internal/external rotation, and iliotibial band flexibility. The following functional outcomes were also assessed: Global Rating of Change Scale, the Kujala score, the Numeric Pain Rating Scale, and the lateral step-down test. Results: Both groups showed significant improvement in the outcome measures. However, the Protonics™ knee brace was more effective than the sport cord for the Global Rating of Change Scale over time (immediate 1.0 [2.1] vs post 2 wk 3.0 [2.2] vs 4 wk 4.6 [2.3] in the Protonics™ brace compared with 0.0 [2.1] vs 1.3 [2.2] vs 3.0 [2.3] in the sport cord, P < .01), suggesting greater satisfaction. Conclusions: Both study groups had significant improvements in the clinical and functional symptoms of patellofemoral pain. The Protonics™ knee brace group was significantly more satisfied with their outcome. However, the sport cord may be a more feasible and cost-effective method that yields similar results in patients with patellofemoral pain syndrome.

scholarly journals Adding Ozone to Dextrose and Somatropin for Intra-Articular Knee Prolotherapy: A Randomized Single-Blinded Controlled Trial

2020 ◽  
Vol 10 (5) ◽  
Author(s):  
Farnad Imani ◽  
Kokab Hejazian ◽  
Mohammad-Reza Kazemi ◽  
Mahnaz Narimani-Zamanabadi ◽  
Khalid M Malik
Keyword(s):  
Controlled Trial ◽  
Alternative Therapy ◽  
Womac Score ◽  
Knee Oa ◽  
The Third ◽  
Anti Oxidant ◽  
The Mean ◽  
And Function ◽  
Hypertonic Dextrose ◽  
Similar Decrease

Background: Prolotherapy, as an alternative therapy, has emerged as an effective treatment for chronic musculoskeletal injury, including knee osteoarthritis (OA). Several studies have mention ozone as a potential treatment for these diseases, which is based on analgesic, anti-inflammatory, and anti-oxidant. Objectives: The current study aimed to investigate the effect of adding ozone gas to hypertonic dextrose and somatropin for knee prolotherapy in patients with knee OA. For this purpose, pain, knee stiffness, and physical activity are measured. Methods: Sixty patients with chronic knee OA were randomly assigned into two groups of DS and DSO. The DS group received intra-articular hypertonic dextrose (10 ml) plus 4 IU somatropin (4 IU), and the DSO group received 10 ml ozone 25 mcg plus intervention in the DS group. This procedure was performed three times (first, third, and fifth weeks). WOMAC score was examined during the third, fifth, and sixteenth weeks. Results: The mean WOMAC score of the DS group was decreased significantly (P < 0.001) sixteen weeks after providing the intervention (before 64.9 ± 10.6, vs. after 49.2 ± 9.0). A similar decrease (P < 0.001) was observed in the DSO group (before 64.1 ± 11.3, vs. after 41.3 ± 8.0). The decrease of the WOMAC score in the third and sixteenth weeks after providing the intervention was significant in the DSO group compared to the DS group (P < 0.005). Conclusions: For patients with knee OA, prolotherapy with ozone plus hypertonic dextrose and somatropin was more effective in sedating the pain and improving the stiffness and function of the knee than dextrose and somatropin alone.

scholarly journals Zoledronic acid plus methylprednisolone versus zoledronic acid or placebo in symptomatic knee osteoarthritis: a randomized controlled trial

2019 ◽  
Vol 11 ◽  
pp. 1759720X1988005 ◽  
Author(s):  
Guoqi Cai ◽  
Laura L Laslett ◽  
Dawn Aitken ◽  
Flavia Cicuttini ◽  
Lyn March ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Zoledronic Acid ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Controlled Trial ◽  
Intravenous Methylprednisolone ◽  
Randomized Controlled ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee ◽  
And Function

Background: The aim of this study was to compare the efficacy and safety of zoledronic acid (ZA) plus intravenous methylprednisolone (VOLT01) to ZA, and placebo for knee osteoarthritis. Methods: A single-center, double-blind, randomized controlled trial (RCT) was carried out. Adults (aged ⩾50 years) with knee osteoarthritis, significant knee pain [⩾40 mm on a 100 mm visual analog scale (VAS)], and magnetic resonance imaging-detected bone marrow lesion (BML) were randomized to receive a one-off administration of VOLT01, ZA, or placebo. The primary hypothesis was that VOLT01 was superior to ZA in having a lower incidence of acute phase responses (APRs) over 3 days. Secondary hypotheses were that VOLT01 was noninferior to ZA, and both treatments were superior to placebo in decreasing BML size over 6 months and in improving knee pain [Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and VAS] and function (WOMAC) over 3 and 6 months. Results: A total of 117 patients (62.2 ± 8.1 years, 63 women) were enrolled. The incidence of APRs was similar in the VOLT01 (90%) and ZA (87%) groups ( p = 0.74). VOLT01 was superior to ZA in improving knee pain and function after 6 months and noninferior to ZA in reducing BML size. However, BML size change was small in all groups and there were no between-group differences. Compared with placebo, VOLT01 but not ZA improved knee function and showed a trend toward improving knee pain after 6 months. Conclusions: Administering intravenous methylprednisolone with ZA did not reduce APRs or change knee BML size over 6 months, but in contrast to ZA or placebo, it may have a beneficial effect on symptoms in knee osteoarthritis. Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN12613000039785.

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