Home parenteral nutrition in advanced cancer: where are we?

2008 ◽  
Vol 33 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Michelle L. Mackenzie ◽  
Leah Gramlich
Keyword(s):  
Parenteral Nutrition ◽  
Advanced Cancer ◽  
Disease Process ◽  
Home Parenteral Nutrition ◽  
Burden Of Care ◽  
Incurable Cancer ◽  
New Family ◽  
The Individual ◽  
And Control

Patients with advanced and incurable cancer are a compelling group. Questions and comments that these individuals and their families have may include: “My daughter is expecting our first grandchild in 3 months — can I hope to see our new family member?”; “I can’t keep any food down — is there anything I can do?”; “I am worried about losing so much weight, and feeling tired and weak — is there anything that may help?”; “Will I suffer a lot?”. Indeed, the most pressing concerns of the patient relate to predictions about survival and control of symptoms. The clinician taking care of the patient may wonder what is the utility or futility of home parenteral nutrition (HPN) in both the individual with advanced cancer and in this population of patients at large, whether there is potential for harm such as increasing the burden of care or prolonging suffering, and how to optimize care and communication with the patient and their families. The nutrition scientist may want to know what the implications of advanced cancer are on nutrient requirements and utilization, whether there are markers that would differentiate between cachexia and simple starvation, and whether it is possible to use specific nutrients to modify the disease process. This review will provide insights into the understanding of the role of HPN in advanced cancer and opportunities for further investigation.

Quality-of-Life Measurement in Advanced Cancer: Assessing the Individual

1999 ◽  
Vol 17 (11) ◽  
pp. 3603-3611 ◽  
Author(s):  
Dympna Waldron ◽  
Ciaran A. O'Boyle ◽  
Michael Kearney ◽  
Michael Moriarty ◽  
Desmond Carney
Keyword(s):  
Quality Of Life ◽  
Advanced Cancer ◽  
Internal Validity ◽  
Semistructured Interview ◽  
Incurable Cancer ◽  
Life Measurement ◽  
The Difference ◽  
The Individual ◽  
Very High

PURPOSE: Despite the increasing importance of assessing quality of life (QoL) in patients with advanced cancer, relatively little is known about individual patient's perceptions of the issues contributing to their QoL. The Schedule for the Evaluation of Individual Quality of Life (SEIQoL) and the shorter SEIQoL–Direct Weighting (SEIQoL-DW) assess individualized QoL using a semistructured interview technique. Here we report findings from the first administration of the SEIQoL and SEIQoL-DW to patients with advanced incurable cancer. PATIENTS AND METHODS: QoL was assessed on a single occasion using the SEIQoL and SEIQoL-DW in 80 patients with advanced incurable cancer. RESULTS: All patients were able to complete the SEIQoL-DW, and 78% completed the SEIQoL. Of a possible score of 100, the median QoL global score was as follows: SEIQoL, 61 (range, 24 to 94); SEIQoL-DW, 60.5 (range, 6 to 95). Psychometric data for SEIQoL indicated very high levels of internal consistency (median r = .90) and internal validity (median R2 = 0.88). Patients' judgments of their QoL were unique to the individual. Family concerns were almost universally rated as more important than health, the difference being significant when measured using the SEIQoL-DW (P = .002). CONCLUSION: Patients with advanced incurable cancer were very good judges of their QoL, and many patients rated their QoL as good. Judgments were highly individual, with very high levels of consistency and validity. The primacy given to health in many QoL questionnaires may be questioned in this population. The implications of these findings are discussed with regard to clinical assessment and advance directives.

The role of phytosterols in patients with hepatic disorders on home parenteral nutrition

1999 ◽  
Vol 11 (12) ◽  
pp. A83
Author(s):  
T. H.J. Naber ◽  
G. Goossens ◽  
M. Hecktors ◽  
P. Demacker ◽  
F. G. Russel
Keyword(s):  
Parenteral Nutrition ◽  
Home Parenteral Nutrition

Body and law in late Anglo-Saxon England

1998 ◽  
Vol 27 ◽  
pp. 209-232 ◽  
Author(s):  
Katherine O'Brien O'Keeffe
Keyword(s):  
The Body ◽  
Anglo Saxon ◽  
Manuscript Production ◽  
History Of ◽  
The Subject ◽  
The Law ◽  
The Individual ◽  
And Control ◽  
Point Of Departure

This article explores some textual dimensions of what I argue is a crucial moment in the history of the Anglo-Saxon subject. For purposes of temporal triangulation, I would locate this moment between roughly 970 and 1035, though these dates function merely as crude, if potent, signposts: the years 970×973 mark the adoption of the Regularis concordia, the ecclesiastical agreement on the practice of a reformed (and markedly continental) monasticism, and 1035 marks the death of Cnut, the Danish king of England, whose laws encode a change in the understanding of the individual before the law. These dates bracket a rich and chaotic time in England: the apex of the project of reform, a flourishing monastic culture, efflorescence of both Latin and vernacular literatures, remarkable manuscript production, but also the renewal of the Viking wars that seemed at times to be signs of the apocalypse and that ultimately would put a Dane on the throne of England. These dates point to two powerful and continuing sets of interests in late Anglo-Saxon England, ecclesiastical and secular, monastic and royal, whose relationships were never simple. This exploration of the subject in Anglo-Saxon England as it is illuminated by the law draws on texts associated with each of these interests and argues their interconnection. Its point of departure will be the body – the way it is configured, regarded, regulated and read in late Anglo-Saxon England. It focuses in particular on the use to which the body is put in juridical discourse: both the increasing role of the body in schemes of inquiry and of punishment and the ways in which the body comes to be used to know and control the subject.

scholarly journals DNA Satellites Are Transcribed as Part of the Non-Coding Genome in Eukaryotes and Bacteria

Genes ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1651
Author(s):  
Juan A. Subirana ◽  
Xavier Messeguer
Keyword(s):  
Tandem Repeats ◽  
Bacillus Coagulans ◽  
C Elegans ◽  
Rna Transcripts ◽  
New Family ◽  
Satellite Rnas ◽  
Bacterium Bacillus ◽  
And Control ◽  
First Time

It has been shown in recent years that many repeated sequences in the genome are expressed as RNA transcripts, although the role of such RNAs is poorly understood. Some isolated and tandem repeats (satellites) have been found to be transcribed, such as mammalian Alu sequences and telomeric/centromeric satellites in different species. However, there is no detailed study on the eventual transcription of the interspersed satellites found in many species. Therefore, we decided to study for the first time the transcription of the abundant DNA satellites in the bacterium Bacillus coagulans and in the nematode Caenorhabditis elegans. We have updated the data for C. elegans satellites using the latest version of the genome. We analyzed the transcription of satellites in both species in available RNA-seq results and found that they are widely transcribed. Our demonstration that satellite RNAs are transcribed adds a new family of non-coding RNAs. This is a field that requires further investigation and will provide a deeper understanding of gene expression and control.

Information Communications in the Higher School Educational Space

10.12737/5419 ◽  
2014 ◽  
Vol 3 (4) ◽  
pp. 26-29
Author(s):  
Захаров ◽  
A. Zakharov
Keyword(s):  
Learning Outcomes ◽  
Large Scale ◽  
Educational Process ◽  
Educational Institutions ◽  
Higher Educational Institutions ◽  
Innovation Development ◽  
Higher Educational ◽  
The Individual ◽  
And Control

Within the Federal Target Programme on the Development of Education in Russia strategic projects on introduction of new models for managing education and arranging educational process are being implemented in all higher educational institutions of this country. This transformation is going on in the context of large-scale use of information and telecommunication technologies, which are aimed to ensure the individual approach to education on the basis of merging educational process with technologies and also to reduce costs for the shift towards innovation development of higher educational institutions. The significant role of self-guided work, stipulated within the third generation educational standards, emphasizes top priority issues both on effective arrangement and control of students’ learning outcomes and on helping to reduce teachers’ efforts for functions to deliver knowledge to learners.

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