The exercise-induced stress response in skeletal muscle: failure during aging

2008 ◽  
Vol 33 (5) ◽  
pp. 1033-1041 ◽  
Author(s):  
Anna C. Kayani ◽  
James P. Morton ◽  
Anne McArdle
Keyword(s):  
Skeletal Muscle ◽  
Stress Response ◽  
Contractile Activity ◽  
Older Individuals ◽  
Adult Skeletal Muscle ◽  
Induced Stress ◽  
Exercise Induced ◽  
Shock Proteins ◽  
Exercise And Training ◽  
And Training

Mammalian adult skeletal muscle adapts to the stress of contractile activity with increased gene expression by yielding a family of highly conserved cytoprotective proteins known as heat shock proteins (HSPs). Although the exercise-induced stress response of both animal and human skeletal muscle is now well documented, the precise mechanisms underlying this adaptation remain unclear. The induction of HSPs after exercise is severely blunted in the muscle of older individuals. This review focuses on the effects of different forms of exercise and training on the induction of HSPs in the muscles of adult individuals, and examines the proposed mechanisms underlying this adaptation. Furthermore, the functional effect of the inability of the muscles of older individuals to adapt in this way is discussed, together with the proposed mechanisms underlying this maladaptation.

The Exercise-Induced Stress Response of Skeletal Muscle, with Specific Emphasis on Humans

2009 ◽  
Vol 39 (8) ◽  
pp. 643-662 ◽  
Author(s):  
James P. Morton ◽  
Anna C. Kayani ◽  
Anne McArdle ◽  
Barry Drust
Keyword(s):  
Skeletal Muscle ◽  
Stress Response ◽  
Induced Stress ◽  
Exercise Induced

Effect of SunGold TM Kiwifruit and Vitamin C Consumption on Ameliorating Exercise‐Induced Stress Response in Women

2021 ◽  
pp. 2001219
Author(s):  
Ajmol Ali ◽  
Sunali Mehta ◽  
Carlene Starck ◽  
Marie Wong ◽  
Wendy J. O'Brien ◽  
...  
Keyword(s):  
Stress Response ◽  
Vitamin C ◽  
Induced Stress ◽  
Exercise Induced

scholarly journals Exercise, heat shock proteins and insulin resistance

2017 ◽  
Vol 373 (1738) ◽  
pp. 20160529 ◽  
Author(s):  
Ashley E. Archer ◽  
Alex T. Von Schulze ◽  
Paige C. Geiger
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Metabolic Effects ◽  
Diabetic Patients ◽  
Alcoholic Fatty Liver ◽  
Insulin Resistant ◽  
Exercise Induced ◽  
Shock Proteins

Best known as chaperones, heat shock proteins (HSPs) also have roles in cell signalling and regulation of metabolism. Rodent studies demonstrate that heat treatment, transgenic overexpression and pharmacological induction of HSP72 prevent high-fat diet-induced glucose intolerance and skeletal muscle insulin resistance. Overexpression of skeletal muscle HSP72 in mice has been shown to increase endurance running capacity nearly twofold and increase mitochondrial content by 50%. A positive correlation between HSP72 mRNA expression and mitochondrial enzyme activity has been observed in human skeletal muscle, and HSP72 expression is markedly decreased in skeletal muscle of insulin resistant and type 2 diabetic patients. In addition, decreased levels of HSP72 correlate with insulin resistance and non-alcoholic fatty liver disease progression in livers from obese patients. These data suggest the targeted induction of HSPs could be a therapeutic approach for preventing metabolic disease by maintaining the body's natural stress response. Exercise elicits a number of metabolic adaptations and is a powerful tool in the prevention and treatment of insulin resistance. Exercise training is also a stimulus for increased HSP expression. Although the underlying mechanism(s) for exercise-induced HSP expression are currently unknown, the HSP response may be critical for the beneficial metabolic effects of exercise. Exercise-induced extracellular HSP release may also contribute to metabolic homeostasis by actively restoring HSP72 content in insulin resistant tissues containing low endogenous levels of HSPs. This article is part of the theme issue ‘Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective’.

Exercise-enhanced satellite cell proliferation and new myonuclear accretion in rat skeletal muscle

2001 ◽  
Vol 90 (4) ◽  
pp. 1407-1414 ◽  
Author(s):  
Heather K. Smith ◽  
Linda Maxwell ◽  
Carol D. Rodgers ◽  
Nancy H. McKee ◽  
Michael J. Plyley
Keyword(s):  
Skeletal Muscle ◽  
Cell Proliferation ◽  
Satellite Cell ◽  
Normal Activity ◽  
Adult Skeletal Muscle ◽  
Vastus Intermedius ◽  
Muscle Loading ◽  
Satellite Cell Proliferation ◽  
Exercise Induced

The effects of increased functional loading on early cellular regenerative events after exercise-induced injury in adult skeletal muscle were examined with the use of in vivo labeling of replicating myofiber nuclei and immunocyto- and histochemical techniques. Satellite cell proliferation in the soleus (Sol) of nonexercised rats (0.4 ± 0.2% of fibers) was unchanged after an initial bout of declined treadmill exercise but was elevated after two (1.0 ± 0.2%, P ≤ 0.01), but not four or seven, daily bouts of the same task. Myonuclei produced over the 7-day period comprised 0.9–1.9% of myonuclei in isolated fibers of Sol, tibialis anterior, and vastus intermedius of nonexercised rats. The accretion of new myonuclei was enhanced ( P ≤ 0.05) in Sol and vastus intermedius by the initial exercise followed by normal activity (to 3.1–3.4% of myonuclei) and more so by continued daily exercise (4.2–5.3%). Observed coincident with a lower incidence of histological fiber injury and unchanged fiber diameter and myonuclei per millimeter, the greater new myonuclear accretion induced by continued muscle loading may contribute to an enhanced fiber repair and regeneration after exercise-induced injury.

Exercise and Training in Women, Part I: Influence of Gender on Exercise and Training Responses

2000 ◽  
Vol 25 (1) ◽  
pp. 19-34 ◽  
Author(s):  
Roy J. Shephard
Keyword(s):  
Physical Activity ◽  
Core Body Temperature ◽  
Maternal Blood ◽  
Employment Standards ◽  
Exercise Induced ◽  
Hormonal Milieu ◽  
Core Body ◽  
Exercise And Training ◽  
And Training ◽  
Average Woman

Exercise and training responses in women are briefly reviewed. Part I of the paper considers the influence of gender on such responses. The average woman has a smaller inherent aerobic power and less muscular strength than a man, reflecting sociocultural influences, physical size, body composition, and hormonal milieu. Nevertheless, the best-trained women can out-perform sedentary men. The handicap of the average woman is offset by a lighter body mass and a tendency to metabolize fat rather than carbohydrate during exercise. A lack of anabolic hormones may limit training increases of muscle bulk in the female. A low initial fitness may enhance the scope for training tolerance, but it also limits tolerance of conditioning. Nevertheless, women seem less vulnerable than men to exercise-induced sudden death and overtraining. Part II of the review considers the influence of the menstrual cycle and pregnancy upon exercise and training responses. Physical activity programmes for young women should take account of possible pregnancy. Potential dangers to the foetus include an excessive rise of core body temperature, a decrease of maternal blood sugar, and foetal hypoxia. Nevertheless, regular moderate exercise generally has a favourable impact upon pregnancy outcomes. Key Words: sex differences, sociocultural issues, biological differences, physical activity, conditioning, menstruation, pregnancy, employment standards

Muscle morphology heterogeneity: control, significance for performance and responses to training

2004 ◽  
Vol 32 ◽  
pp. 11-25
Author(s):  
J L L Rivero
Keyword(s):  
Skeletal Muscle ◽  
Muscle Blood Flow ◽  
Adaptive Plasticity ◽  
Muscle Fibres ◽  
The Past ◽  
Skeletal Musculature ◽  
Skeletal Muscle Fibres ◽  
Exercise And Training ◽  
And Training ◽  
Total Muscle

The skeletal musculature of the horse is highly developed and adapted to match the animal's athletic potential. More than half of a mature horse's body weight comprises skeletal muscle and the total muscle blood flow during maximal exercise represents 78% of total cardiac output. Exercise requires the co–ordinated application of many different body systems under the control of the nervous systems. Metabolites and oxygen reach skeletal muscle fibres via the respiratory, cardiovascular and haematological systems. The muscle fibres produce energy in the form of ATP that, via the contractile machinery, is converted into mechanical work. The structural arrangements of the musculoskeletal system provides the means with which to harness this energy to move the horse's limbs in a characteristic rhythmical pattern that is well established for each gait.Equine skeletal muscle is considerably heterogeneous and this diversity reflects functional specialisation and is the basis of its adaptive plasticity. Cellular and molecular diversity of equine muscle and the response of this tissue to exercise and training have been studied extensively over the past 30 years.

Sign in / Sign up

Export Citation Format

Share Document