Effets du chlorhydrate d'heptaminol sur la transmission neuromusculaire
1988 ◽
Vol 66
(11)
◽
pp. 1442-1449
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Keyword(s):
6-Amino-2-methyl-2-heptanol chlorhydrate, heptaminol chlorhydrate, blocks the response to indirect stimulation of the mouse diaphragm in vitro. This effect is due to a dose-dependent pre- and post-synaptic block of neuromuscular transmission starting at 1 mM heptaminol (HEPT). The complete block of neuromuscular transmission occurs at 10 mM. At 2 mM, the decrease in quantal size is more significant in the presence of d-tubocurarine than when the extracellular calcium is lowered. At this concentration, heptaminol also prolongs the depolarization time of the motor end plate potential. Slightly higher concentrations of heptaminol produce a decrease in quantal content. This latter effect is associated with an increase in synaptic delay.
1983 ◽
Vol 245
(4)
◽
pp. G463-G469
Keyword(s):
2003 ◽
Vol 90
(3)
◽
pp. 2074-2079
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Keyword(s):
1990 ◽
Vol 5
(1)
◽
pp. 55-60
◽
Keyword(s):
1980 ◽
Vol 239
(3)
◽
pp. G198-G203
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Keyword(s):
Keyword(s):
2000 ◽
Vol 83
(06)
◽
pp. 937-943
◽
Keyword(s):
1981 ◽
Vol 240
(1)
◽
pp. G10-G16
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