MODELLING IN BONE BIOMECHANICS

2006 ◽  
pp. 451-491
Author(s):  
J. C. MISRA ◽  
S. SAMANTA
Keyword(s):  
Bone Biomechanics

scholarly journals Protective Effects of Moderate Ca Supplementation against Cd-Induced Bone Damage under Different Population-Relevant Doses in Young Female Rats

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 849 ◽  
Author(s):  
Huang ◽  
Liu ◽  
Zhao ◽  
Fu ◽  
Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Formation ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Young Female ◽  
Female Rats ◽  
Bone Biomechanics ◽  
Protective Effects ◽  
Fibroblast Growth ◽  
Bone Damage

Estimation of the skeleton-protective effects of Ca in Cd-induced bone damage is helpful in the assessment of Cd health risk. The aim of this study was to identify whether Ca supplementation during exposure to different population-relevant doses of Cd can prevent Cd-induced bone damage under the tolerable upper intake level of Ca supplementation. Young female Sprague-Dawley rats were given different population-relevant doses of Cd (1, 5, and 50 mg Cd/kg diet) and Ca supplementation (0.4% Ca supplementation) intervention. Ca supplementation significantly decreased Cd-induced bone microstructure damage, increased bone biomechanics (p < 0.05), serum bone formation marker level (p < 0.05) and expression of osteogenic gene markers exposure to the 5 and 50 mg Cd/kg diets. However, it had no impact on these indicators under the 1 mg Cd/kg diets, with the exception of expression of osteogenic marker genes. Ca supplementation significantly decreased serum Klotho level (p < 0.05), and fibroblast growth factor 23/Klotho-associated gene expression in the kidney and bone showed significant changes. In conclusion, Ca supplementation has a positive effect on bone formation and bone quality against the damaging impact of Cd, especially with exposure to the 5 mg and 50 mg Cd/kg diet, which may be related to its impact on the fibroblast growth factor 23/Klotho axis.

scholarly journals Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Wenna Liang ◽  
Xihai Li ◽  
Guanhui Li ◽  
Liu Hu ◽  
Shanshan Ding ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Crucial Role ◽  
Molecular Mechanisms ◽  
Bone Biomechanics ◽  
Ovariectomized Rats ◽  
Therapeutic Effects ◽  
Bone Morphology ◽  
Mineral Density ◽  
Metabolism Disorder ◽  
Successful Establishment

Background. Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP. We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model. We then investigated the expression of biomarkers related to the Sirt1/Foxo axis. We also examined microRNA-132 (miR-132), a regulator in the Sirtuin1 (Sirt1) expression. The bone metabolism disorder, bone morphology, BMD, and bone biomechanics in ovariectomized rats were improved by EZP administration. The antiosteoporotic effect of EZP was confirmed. We also found that the expressions of Sirt1, Runx2, Foxo1, and Foxo3a were downregulated in ovariectomized rats, while being then upregulated by EZP administration. And the expression of PPAR-γ and miR-132 was upregulated in ovariectomized rats and then downregulated by EZP administration. These results provided evidence that Sirt1/Foxo axis related mechanism may play a crucial role in the therapeutic effects of EZP, indicating that Sirt1/Foxo axis can be considered as a potential therapeutic target for PMOP in the future.

scholarly journals Functional microimaging: an integrated approach for advanced bone biomechanics and failure analysis

2006 ◽  
Author(s):  
Romain Voide ◽  
G. H. van Lenthe ◽  
Philipp Schneider ◽  
Philipp J. Thurner ◽  
Peter Wyss ◽  
...  
Keyword(s):  
Failure Analysis ◽  
Integrated Approach ◽  
Bone Biomechanics

Bone biomechanics

1997 ◽  
Vol 25 (1) ◽  
pp. S-72
Author(s):  
Bob Sah ◽  
Tony Keaveny ◽  
Ken Fischer
Keyword(s):  
Bone Biomechanics

Changes of bone mineral density and bone biomechanics in type 2 diabetic model of female rats

Bone ◽  
2008 ◽  
Vol 42 ◽  
pp. S59-S60
Author(s):  
Yaping Liu ◽  
Hong Ji ◽  
Haiqin Rong ◽  
Liping Zhang ◽  
Xinbo Zhao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Female Rats ◽  
Bone Biomechanics ◽  
Mineral Density ◽  
Diabetic Model ◽  
Type 2 Diabetic

scholarly journals Current concepts in osteogenesis imperfecta: bone structure, biomechanics and medical management

2019 ◽  
Vol 13 (1) ◽  
pp. 1-11 ◽  
Author(s):  
W. H. Nijhuis ◽  
D. M. Eastwood ◽  
J. Allgrove ◽  
I. Hvid ◽  
H. H. Weinans ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Bone Structure ◽  
Bone Matrix ◽  
Bone Architecture ◽  
Mechanical Anisotropy ◽  
Bone Biomechanics ◽  
Mineral Density ◽  
Trabecular Thickness ◽  
Osteocyte Lacunae ◽  
Vitamin D Levels

The majority of patients with osteogenesis imperfecta (OI) have mutations in the COL1A1 or COL1A2 gene, which has consequences for the composition of the bone matrix and bone architecture. The mutations result in overmodified collagen molecules, thinner collagen fibres and hypermineralization of bone tissue at a bone matrix level. Trabecular bone in OI is characterized by a lower trabecular number and connectivity as well as a lower trabecular thickness and volumetric bone mass. Cortical bone shows a decreased cortical thickness with less mechanical anisotropy and an increased pore percentage as a result of increased osteocyte lacunae and vascular porosity. Most OI patients have mutations at different locations in the COL1 gene. Disease severity in OI is probably partly determined by the nature of the primary collagen defect and its location with respect to the C-terminus of the collagen protein. The overall bone biomechanics result in a relatively weak and brittle structure. Since this is a result of all of the above-­mentioned factors as well as their interactions, there is ­considerable variation between patients, and accurate prediction on bone strength in the individual patient with OI is difficult. Current treatment of OI focuses on adequate vitamin-D levels and interventions in the bone turnover cycle with bisphosphonates. Bisphosphonates increase bone mineral density, but the evidence on improvement of clinical status remains limited. Effects of newer drugs such as antibodies against RANKL and sclerostin are currently under investigation. This paper was written under the guidance of the Study Group Genetics and Metabolic Diseases of the European Paediatric Orthopaedic Society.

Comparative Effects of Bicalutamide (Casodex) versus Orchidectomy on Bone Mineral Density, Bone Remodelling, and Bone Biomechanics in Healthy Rats

2005 ◽  
Vol 74 (4) ◽  
pp. 301-307 ◽  
Author(s):  
Mar Lefort ◽  
Manuel Díaz Curiel ◽  
María-Teresa Carrascal ◽  
Cioly Méndez-Dávila ◽  
Concepción de la Piedra
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Remodelling ◽  
Bone Biomechanics ◽  
Mineral Density
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