Graphene Quantum Dots for Drug Delivery

2017 ◽  
pp. 115-125 ◽  
Author(s):  
Yang Chen ◽  
Maoquan Chu
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Graphene Quantum Dots

A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2011-2025 ◽  
Author(s):  
Zhen Li ◽  
Jialong Fan ◽  
Chunyi Tong ◽  
Hongyan Zhou ◽  
Wenmiao Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graphene Quantum Dots ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

scholarly journals Incorporation of Graphene Quantum Dots, Iron, and Doxorubicin in/on Ferritin Nanocages for Bimodal Imaging and Drug Delivery

2020 ◽  
Vol 3 (3) ◽  
pp. 1900183 ◽  
Author(s):  
Fatemeh Nasrollahi ◽  
Barindra Sana ◽  
David Paramelle ◽  
Samad Ahadian ◽  
Ali Khademhosseini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Bimodal Imaging

Versatile Nanoplatform Loaded with Doxorubicin and Graphene Quantum Dots/Methylene Blue for Drug Delivery and Chemophotothermal/Photodynamic Synergetic Cancer Therapy

2020 ◽  
Vol 3 (10) ◽  
pp. 7122-7132
Author(s):  
Junlong Liang ◽  
Jianjun Liu ◽  
Xiaokang Jin ◽  
Shuting Yao ◽  
Biling Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Methylene Blue ◽  
Quantum Dots ◽  
Cancer Therapy ◽  
Graphene Quantum Dots

scholarly journals Graphene quantum dots-gated hollow mesoporous carbon nanoplatform for targeting drug delivery and synergistic chemo-photothermal therapy

2018 ◽  
Vol Volume 13 ◽  
pp. 5991-6007 ◽  
Author(s):  
Junfeng Fang ◽  
Yanqing Liu ◽  
Yiwen Chen ◽  
Dimei Ouyang ◽  
Guangji Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Photothermal Therapy ◽  
Mesoporous Carbon ◽  
Graphene Quantum Dots

Multifunctional graphene quantum dots for simultaneous targeted cellular imaging and drug delivery

2014 ◽  
Vol 122 ◽  
pp. 638-644 ◽  
Author(s):  
Xiaojuan Wang ◽  
Xing Sun ◽  
Jun Lao ◽  
Hua He ◽  
Tiantian Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Graphene Quantum Dots ◽  
Cellular Imaging

scholarly journals Synthesis of graphene quantum dots and their applications in drug delivery

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Changhong Zhao ◽  
Xuebin Song ◽  
Ya Liu ◽  
Yifeng Fu ◽  
Lilei Ye ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Drug Delivery Systems ◽  
Graphene Quantum Dots ◽  
Delivery Systems ◽  
Core Shell ◽  
Recent Advances ◽  
Prospective Application

Abstract This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

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