In this talk, I discuss recent developments concerning the possibility of large extra space-ime dimensions and their relation to neutrino physics. After briefly reviewing how such dimensions can lower the fundamental GUT, Planck, and string scales, I then outline how these scenarios lead to a new higher-dimensional seesaw mechanism for generating neutrino oscillations — perhaps even without neutrino masses. I also discuss how neutrino flavor oscillations can occur in a higher-dimensional theory even if the Standard Model on the brane is flavor-diagonal, the bulk theory is flavor-neutral, and the brane/bulk couplings are flavor-blind. This talk reports on work done in collaboration with Emilian Dudas, Tony Gherghetta, and Ina Sarcevic.