CALCULATION OF THE CROSSING TIME THROUGH THE FITNESS BARRIER IN A SYMMETRIC MULTIPLICATIVE LANDSCAPE

2005 ◽  
Vol 16 (01) ◽  
pp. 85-97 ◽  
Author(s):  
DOKYOON KIM ◽  
WONPYONG GILL

The crossing time through fitness barrier in a symmetric multiplicative landscape is systematically calculated for various mutation rates, fitness parameters, and sequence lengths by using a computer simulation. It is found that the crossing time scales as a power law in the mutation rate and the fitness parameter. It is also found that the crossing time increases exponentially as the sequence length increases. We have obtained the approximate formula, which decribes the asymptotic behavior of the crossing time in the long-crossing-time region, and the improved approximate formula with the correction factor, which nicely fit computer simulation results even below the long-crossing-time region. From the comparison between the approximate formula in the multiplicative landscape and the approximate formula in the sharply-peaked landscape, it is found that both landscapes have the same scaling effect of fitness parameter and mutation rate on the crossing time in the long-crossing-time region.

2016 ◽  
Vol 27 (06) ◽  
pp. 1650070
Author(s):  
Wonpyong Gill

This study calculated the growing probability of additional offspring with the advantageous reversal allele in an asymmetric sharply-peaked landscape using the decoupled continuous-time mutation–selection model. The growing probability was calculated for various population sizes, N, sequence lengths, L, selective advantages, s, fitness parameters, k and measuring parameters, C. The saturated growing probability in the stochastic region was approximately the effective selective advantage, [Formula: see text], when [Formula: see text] and [Formula: see text]. The present study suggests that the growing probability in the stochastic region in the decoupled continuous-time mutation–selection model can be described using the theoretical formula for the growing probability in the Moran two-allele model. The selective advantage ratio, which represents the ratio of the effective selective advantage to the selective advantage, does not depend on the population size, selective advantage, measuring parameter and fitness parameter; instead the selective advantage ratio decreases with the increasing sequence length.


2013 ◽  
Vol 24 (01) ◽  
pp. 1250091 ◽  
Author(s):  
WONPYONG GILL

This study calculated the crossing time in the diploid mutation–selection model in an infinite population limit for various dominance parameters, h, and selective advantages, by switching on a diploid, asymmetric, sharply-peaked landscape, from an initial state which is the steady state in a diploid, sharply-peaked landscape. The crossing time for h < 1 was found to diverge at the critical fitness parameter, which increased with increasing selective advantage and decreased with increasing sequence length. When the sequence length was increased with a fixed extension parameter, there was no crossing time for h < 1 when the sequence length was longer than the critical sequence length, which increased with increasing selective advantage. The crossing time for h ≤ 1 was found to be an exponentially increasing function of the sequence length, and the crossing time for h > 1 became saturated at a long sequence length. The crossing time decreased with increasing selective advantage, mainly because the larger selective advantage caused the increase in relative density of the reversal allele to grow exponentially at an earlier time.


2007 ◽  
Vol 18 (12) ◽  
pp. 1985-1996 ◽  
Author(s):  
KWANG SUNG LEE ◽  
WONPYONG GILL

We have calculated the relative density and crossing time through the fitness barrier by switching on an asymmetric sharply-peaked landscape, from the initial state which is the quasispecies in a sharply-peaked landscape. It is found that the increment of the relative density with the reversal sequence is a linearly increasing function of time unless a new stationary state in an asymmetric sharply-peaked landscape is reached. It is also found that the relative density with the reversal sequence at the new stationary state [Formula: see text] is in inverse proportion to the asymmetric parameter when the asymmetric parameter is greater than the saturation asymmetric parameter. We have derived the approximate formulae for the relaxation time, the saturation asymmetric parameter, and the relative density with the reversal sequence [Formula: see text], which nicely fit computer simulation results. It is found that the crossing time diverges at the critical fitness parameter in the asymmetric sharply-peaked landscape, in contrast with the symmetric sharply-peaked landscape where the crossing time scales as a power law in the fitness parameter. It is also found that the critical fitness parameter decreases as the asymmetric parameter and sequence length increase.


Author(s):  
D T Pham ◽  
D Karaboga

Three variable mutation rate strategies for improving the performance of genetic algorithms (GAs) are described. The problem of optimizing fuzzy logic controllers is used to evaluate a GA adopting these strategies against a GA employing a static mutation regime. Simulation results for a second-order time-delayed system controlled by fuzzy logic controllers (FLCs) obtained using the different GAs are presented.


Author(s):  
Shakhboz Dadabaev

The main negative factors affecting the starting modes of synchronous electric drives of pumping units of irrigation water supply systems were identified, computer simulation of direct and soft start of synchronous electric drive was made, the simulation results are shown in graphs and a brief conclusion was made on the study.


1998 ◽  
Vol 38 (2) ◽  
pp. 201-208
Author(s):  
M. W. Milke

A need exists for tools to improve evaluations of the economics of landfill gas recovery. A computer simulation tool is presented. It uses a spreadsheet computer program to calculate the economics for a fixed set of inputs, and a simulation program to consider variations in the inputs. The method calculates the methane generated each year, and estimates the costs and incomes associated with the recovery and sale of the gas. Base case results are presented for a city of 500,000. An uncertainty analysis for a hypothetical case is presented. The simulation results can help an analyst see the key variables affecting the economics of a project.


2013 ◽  
Vol 336-338 ◽  
pp. 734-737
Author(s):  
Hong Yu Zheng ◽  
Ya Ning Han ◽  
Chang Fu Zong

In order to solve the problem of road feel feedback of vehicle steer-by-wire (SBW) system based on joystick, a road feel control strategy was established to analyze the road feel theory of traditional steer system, which included return, assist and damp control module. By verifying the computer simulation results with the control strategy from software of CarSim and Matlab/Simulink, it shows that the proposed strategy can effective get road feel in different vehicle speed conditions and could improve the vehicle maneuverability to achieve desired steering feel by different drivers.


1990 ◽  
Vol 213 ◽  
Author(s):  
T.A. Parthasarathy ◽  
D.M. Dimiduk ◽  
C. Woodward ◽  
D. Diller

ABSTRACTDissociation of the ao<110> screw dislocation in Ni3Al was studied using the embedded atom method of computer simulation. The dissociation occurred predominantly along the {111} plane, however, a {001}-plane step occurred in the APB at the center of the configuration. When a pair of ao/2<110> superpartials initially separated in the {111} plane was relaxed, the step formed once again but with a reduced height. When the pair was relaxed from larger distances the step was not formed. The results indicate that the elastic interaction “torque” due to elastic anisotropy is responsible for the formation of the {001} APB step. When a stress was applied to these dislocation configurations by simulation, results confirmed that the step in the APB and the octahedral cross-slipped-core dissociations can be significant barriers to glide of the screw dislocation.


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