Factors Influencing Aphasia Assessment for Bilingual Adults

This chapter provides a brief overview of stroke, aphasia, and aphasia assessment. Additionally, it considers various issues associated with the standardized assessment of aphasia, including problems related to cultural and linguistic biases. The chapter also includes information on working with people who are bilingual, as well as working with interpreters. A hypothetical case study is presented as a teaching avenue to discuss these topics in greater length. This section contains details regarding how both cultural and linguistic barriers associated with the assessment of the patient's aphasia may have influenced the intervention provided by the speech-language pathologist (SLP). Medical terminology and procedures related to stroke intervention are also discussed as it relates to the SLP's plan of care.

Designing a PhD Proposal in Mixed Method Research

This chapter reviews the challenges and advantages of writing a mixed method research (MMR) proposal. The argument put forward is that a mixed method approach overcomes the shortcomings of the commonly used qualitative and quantitative methods. A brief definition of a research proposal is followed by a discussion on the different interpretations of a mixed method and what makes mixed methods ideal in the proposal example that follows. A mixed method can be either one that utilizes qualitative and quantitative methods to different degrees or it can be regarded as a distinct method by itself. A mixed method is suitable where both different types of data can be collected, when the data adds value to what would be achieved using one approach and where cost also justifies it. A hypothetical case example where an application is being made to conduct an evaluation of an anti-truancy program is presented.

Intentions and Cyberterrorism

This chapter focuses on intentions and cyberterrorists. In defining cyberterrorism as the use, or threat of use, of cyberspace to deliver violence, through the disruption or destruction of digital data, the chapter captures potentially novel behaviour. It highlights the claims made by intelligence officials about terrorists’ intentions of using cyberspace. It then interrogates to what extent this matches the literature on terrorist motivations and intentions, and whether cyberspace is an attractive means for carrying out terrorist attacks. Finding that a simple cost–benefit analysis does not favour cyberspace as a means of carrying out terrorist acts, the chapter interrogates the vectors of change both on the intentions and capability side of the assessment. It closes with the analysis of a hypothetical case that would match the definition of cyberterror: a religiously inspired version of the Ashley Madison hack.

Immunogenicity Risk Assessment for Multi-specific Therapeutics

The objective of this manuscript is to provide the reader with a hypothetical case study to present an immunogenicity risk assessment for a multi-specific therapeutic as part of Investigational New Drug (IND) application. In order to provide context for the bioanalytical strategies used to support the multi-specific therapeutic presented herein, the introduction focuses on known immunogenicity risk factors. The subsequent hypothetical case study applies these principles to a specific example HC-12, based loosely on anti-TNFα and anti-IL-17A bispecific molecules previously in development, structured as an example immunogenicity risk assessment for submission to health authorities. The risk of higher incidence and safety impact of anti-drug antibodies (ADA) due to large protein complexes is explored in the context of multi-specificity and multi-valency of the therapeutic in combination with the oligomeric forms of the targets.

None of My Business? An Experiment Analyzing Willingness to Formally Report Incidents of Intimate Partner Violence Against Women

Although data show that intimate partner violence against women (IPVAW) is a concealed phenomenon that is severely underreported, studies examining willingness to report episodes of IPVAW are limited. To contribute to this field of research, a factorial survey experiment was implemented in which each respondent ( N = 1,007) received a unique vignette describing a hypothetical case of IPVAW. Slightly over one in four respondents (28.1%) indicated that they would report the aggression. It was also found that willingness to report was influenced by both the characteristics of the vignettes and certain personal ones of the respondents. Practical implications are proposed that may contribute to preventing IPVAW.

A Resilience-Based Model for the Seismic Assessment of the Functionality of Road Networks Affected by Bridge Damage and Restoration

Road network functionality after an earthquake is a crucial aspect for an already struck community. In particular, bridges are susceptible to earthquake-induced damages and to lengthy restoration works. This may lead to severe and unexpected disruption of traffic. In this paper, a model for the assessment of the seismic resilience of a road network is presented. The proposed model permits us to evaluate the earthquake-induced perturbations to the functionality of a network in terms of transportation capacities, traffic congestion, and travel times due to bridge damages and subsequent restoration interventions. The evolution over time of the functionality of the network is studied by means of a multi-stage approach describing the evolution of the situation in terms of reducing the normal pre-earthquakes transportation capacities. The methodology has been illustrated with reference to a hypothetical case study, a road network composed of 14 nodes and 31 links.

Ethical concerns in Neonatal Intensive Unit: A Case Analysis

Neonatal nurses frequently encounter neonatal ethical issues related to provision of safe and quality care and communication in the NICU setup. This article discusses the hypothetical case of baby John diagnosed with neonatal sepsis. The ethical perspectives related to care and communication with the family members while their baby is receiving treatment in the NICU will be explored through the application of the QUAR framework.

LGBT testimony and the limits of trust

In, ‘Forever young: the ethics of ongoing puberty suppression (OPS) for non-binary adults,’ Notini et al discuss the risks, harms and benefits of treating non-binary patients via identity-affirming OPS. Notini et al’s article makes a strong case for OPS’s permissibility, and their conclusion will not be disputed here. Instead, I directly focus on issues that their article addressed only indirectly. This article will use a hypothetical case study to show that while Notini et al’s ethical conclusion might be spot on, that perhaps the method they took to get there was superfluous. If the medical community is to take LGBT testimony seriously (as they should) then it is no longer the job of physicians to do their own weighing of the costs and benefits of transition-related care. Assuming the patient is informed and competent, then only the patient can make this assessment, because only the patient has access to the true weight of transition-related benefits. Moreover, taking LGBT patient testimony seriously also means that parents should lose veto power over most transition-related paediatric care.

Synthesis of Short-Cut DCF Appraisal and Spreadsheet Iteration of Freehold Rental Growth Rates Across Specific Valuation Epochs

While the use of simple deterministic models to calculate rental value growth (RVGrowth) rate of reversionary freeholds across epochs prior to upward rent review appears illusive, literature evidence of the synthesis between short-cut DCF valuation and Solver tools in a spreadsheet does not constitute an exhaustive list of solutions. This study examined alternative spreadsheet and iteration tools that can determine RVGrowth rate of freehold investment properties across rent review epochs. With recourse to a hypothetical case of a freehold investment property, this experimental study identified the mathematical composition of RVGrowth in an explicit DCF framework, performed short-cut DCF Valuation and equivalent yield calculation at specific epochs prior to and including the full reversion; as well as using Goal Seek to calculate RVGrowth across all epochs prior to- and including the full reversion. Excel® Solver and Goal Seek, as well as the graphing/root-solving tool in Kyplot® were found to feasibly produce identical results for RVGrowth rate. This is among the limited studies that identified and researched the veracity of alternative tools for RVGrowth rate iteration. The value of this study is the awareness of alternative analytical tools avail freehold investors who desire knowledge of RVGrowth rate when making purchase-, hold-, and sales decisions.