DNA and DNA computation based on toehold-mediated strand displacement reactions

2018 ◽  
Vol 32 (18) ◽  
pp. 1840014 ◽  
Author(s):  
Yijun Guo ◽  
Bing Wei ◽  
Xianbao Sun ◽  
Dongbao Yao ◽  
Xiang Zhou ◽  
...  
Keyword(s):  
Self Assembly ◽  
Deoxyribonucleic Acid ◽  
Strand Displacement ◽  
Replacement Reaction ◽  
Dna Computation ◽  
Displacement Reactions ◽  
Good Biocompatibility ◽  
Dna Strand ◽  
Molecular Calculations ◽  
Microcosmic Mechanism

Other than being a carrier of the code of life deoxyribonucleic acid (DNA) can also be used as a kind of ideal biomaterial with good biocompatibility. The basis of DNA dynamic nanotechnology is the toehold-mediated strand displacement reactions. Utilizing the specificity and predictability of Watson–Crick base pairing, and the programmability of the base sequence of DNA, researchers can construct the molecular machine and precisely control its operation to realize various complex molecular calculations. In this paper, we reviewed the progress of DNA structure and mechanical properties in recent years, discussed the microcosmic mechanism of DNA strand replacement reaction, and introduced the latest achievements in DNA molecular computing and its application in DNA constant temperature self-assembly.

Biocomputing based on DNA strand displacement reactions

ChemPhysChem ◽  
2021 ◽  
Author(s):  
Hui Lv ◽  
Qian Li ◽  
Jiye Shi ◽  
Fei Wang ◽  
Chunhai Fan
Keyword(s):  
Strand Displacement ◽  
Dna Strand Displacement ◽  
Displacement Reactions ◽  
Dna Strand

Connecting localized DNA strand displacement reactions

Nanoscale ◽  
2015 ◽  
Vol 7 (30) ◽  
pp. 12970-12978 ◽  
Author(s):  
Ismael Mullor Ruiz ◽  
Jean-Michel Arbona ◽  
Amitkumar Lad ◽  
Oscar Mendoza ◽  
Jean-Pierre Aimé ◽  
...  
Keyword(s):  
Dna Origami ◽  
Strand Displacement ◽  
Dna Strand Displacement ◽  
Displacement Reactions ◽  
Dna Strand

Design and characterization of a DNA-based localized amplification circuit which, upon tethering on a DNA origami platform, greatly accelerates the catalytic response.

The fast detection of streptavidin based on the initial reaction rate of the binding-induced DNA strand-displacement reaction

2016 ◽  
Vol 8 (37) ◽  
pp. 6701-6704 ◽  
Author(s):  
Chenxi Li ◽  
Ruoyun Lin ◽  
Tian Li ◽  
Feng Liu ◽  
Na Li
Keyword(s):  
Small Molecules ◽  
Reaction Rate ◽  
Initial Reaction Rate ◽  
Initial Reaction ◽  
Strand Displacement ◽  
Fast Detection ◽  
Dna Strand Displacement ◽  
Displacement Reactions ◽  
Dna Strand ◽  
Strand Displacement Reaction

Binding-induced DNA strand-displacement reactions diversify the applications beyond nucleic acids and small molecules.

Integrating DNA-Strand-Displacement Circuitry with Self-Assembly of Spherical Nucleic Acids

2015 ◽  
Vol 137 (44) ◽  
pp. 14107-14113 ◽  
Author(s):  
Dongbao Yao ◽  
Tingjie Song ◽  
Xianbao Sun ◽  
Shiyan Xiao ◽  
Fujian Huang ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Self Assembly ◽  
Strand Displacement ◽  
Dna Strand Displacement ◽  
Dna Strand ◽  
Spherical Nucleic Acids
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