JOINT IMPACTS OF THERAPY DURATION, DRUG EFFICACY AND TIME LAG IN IMMUNE EXPANSION ON IMMUNITY BOOSTING BY ANTIVIRAL THERAPY

Antiviral drug therapy that targets on boosting virus-specific immune response has become very promising in controlling the virus, especially when completely eradicating the virus from the host turns out to be difficult. Using a concrete viral infection model that incorporates the time lag needed for the expansion of immune cells, we numerically explored the joint impacts of the duration of therapy, the efficacy of the drugs and the time lag in immune expansion on immunity boosting for a single phase of therapy. Our findings reveal that a single phase of therapy can establish sustained immunity if the therapy is stopped in a suitable range of timing and large time lag in the expansion of immune cells and too strong or too weak therapy would lead to a failure in immunity boosting. Our findings may provide some insights on designing efficient and rational therapy strategies in boosting sustained immunity.