EXPRESSION OF CYTOKINES IN THE DORSAL ROOT GANGLION CELL BODY IN AN EXPERIMENTAL MODEL OF ENTRAPMENT NEUROPATHY

Hand Surgery ◽  
1998 ◽  
Vol 03 (02) ◽  
pp. 175-183 ◽  
Author(s):  
S. Yamamoto ◽  
M. Ochi ◽  
N. Shu ◽  
K. Ryoke ◽  
H. Yamaguchi
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Motor Nerve ◽  
Recovery Process ◽  
Motor Nerve Conduction Velocity ◽  
Entrapment Neuropathy ◽  
Dorsal Root Ganglion Cell ◽  
Silicone Tube ◽  
Male Wistar Rats ◽  
Tgf Β1

An experimental entrapment neuropathy model was produced by wrapping the sciatic nerve with a silicone tube using 54 adult male Wistar rats. We observed the changes in expression of IL-1 and TGF-β1 in the dorsal root ganglion during the formation as well as recovery process after removal of the tube, together with electrophysiological changes. Expression of IL-1 reached its peak 2 months after tubing, while expression of TGF-β1 peaked at 6 months and thereafter slowly decreased. Motor nerve conduction velocity (MNCV) significantly decreased 8 months after tubing. Removal of the silicone tube at 8 months after tubing, induced a significant increase in the level of IL-1 expression at 1 month after the removal, and that in the level of TGF-β1 expression at 2 months after the removal, at which time MNCV began to show a significant recovery. We have concluded from these results that IL-1 and TGF-β1 are deeply involved in the formation as well as the recovery process of entrapment neuropathy.

The generation of rat dorsal root ganglion cell lines to identify the target of KW-7158, a novel treatment for overactive bladder

2011 ◽  
Vol 71 (3) ◽  
pp. 278-288 ◽  
Author(s):  
Yoichi Nishiya ◽  
Sachiko Yokokawa ◽  
Ayumu Fukuda ◽  
Tsuyoshi Yamagata ◽  
Atsushi Inayoshi ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Overactive Bladder ◽  
Ganglion Cell ◽  
Cell Lines ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Cell ◽  
Novel Treatment

scholarly journals 3D-Printed pHEMA Materials for Topographical and Biochemical Modulation of Dorsal Root Ganglion Cell Response

2017 ◽  
Vol 9 (36) ◽  
pp. 30318-30328 ◽  
Author(s):  
Adina Badea ◽  
Joselle M. McCracken ◽  
Emily G. Tillmaand ◽  
Mikhail E. Kandel ◽  
Aaron W. Oraham ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Ganglion Cell ◽  
Cell Response ◽  
Dorsal Root ◽  
Biochemical Modulation ◽  
Dorsal Root Ganglion Cell ◽  
3D Printed

Dorsal root ganglion stimulation for the treatment of severe intractable pain related to obturator nerve entrapment neuropathy: A case report

2020 ◽  
Vol 198 ◽  
pp. 106138 ◽  
Author(s):  
Reda Tolba ◽  
Alvah Tyson Wickboldt ◽  
Ashley Peairs ◽  
Hossam Eldin Mohamed ◽  
Myles Storey ◽  
...  
Keyword(s):  
Case Report ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Obturator Nerve ◽  
Nerve Entrapment ◽  
Entrapment Neuropathy ◽  
Intractable Pain

Selective Reinnervation of Regenerating Mixed Nerve Fibres Across a Silicone Tube Gap

1996 ◽  
Vol 21 (5) ◽  
pp. 660-663 ◽  
Author(s):  
Z-J. LUO ◽  
S-B. LU
Keyword(s):  
Dorsal Root ◽  
Tibial Nerve ◽  
Motor Nerve ◽  
Sensory Nerve ◽  
Nerve Fibres ◽  
Silicone Tube ◽  
Spinal Dorsal ◽  
Sensory Axons ◽  
Target Organs ◽  
Mixed Nerve

This study investigated specific regeneration of a mixed motor and sensory nerve by the method of spinal dorsal root ganglions resection. A 10 mm segment of tibial nerve was resected and the nerve ends inserted in a silicone tube. Fourteen weeks later, dorsal root ganglia from L6 to S1 were resected on the experiment side. Twenty weeks later, the regenerating motor nerve fibres of mixed nerves selectively grew into motor branches. The rate of misdirected growth in mixed nerves was less than 6%. These results suggest that regenerating motor and sensory axons of mixed nerves are able to select their distal target organs accurately. Better results may be obtained using the entubulation repair method.

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