A NEW APPROACH FOR ASSESSMENT OF PULSE WAVE VELOCITY AT RADIAL ARTERY IN YOUNG AND MIDDLE-AGED HEALTHY HUMANS

Pulse wave velocity (PWV), based on two-site measurement, is a well-known predictor of arterial stiffness. Interest focused increasingly on simplifying the PWV measurement results in attempts at determining it at a single site. We aimed to validate a new tonometric method (IIM-2010A) for assessment of PWV at radial artery in healthy subjects <65 years of age. PWV measurements were performed in 46 healthy adults (25 men and 21 women) aged 21–65 years (39.6 ± 15.5 years) using Complior device and IIM-2010A respectively. In a subgroup of 21 humans, the measurements were repeated after 1 week using IIM-2010A with the same protocol. There was a strong correlation between PWV obtained by IIM-2010A and PWV obtained by Complior, as well as between pulse transit time (PTT) measurements (r = 0.79 and r = 0.85, respectively, P < 0.01 for both). Although PTT was significantly lower measured by IIM-2010A, no significant difference was found in PWV. The mean difference of PWV with SD was -0.1 ± 1.2 m/s between two repeated measurements at intervals of 1 week. Bland–Altman's plot indicated no trend for the reproducibility of measurements to vary with their underlying mean value. Intraclass correlation coefficient (= 0.87) confirmed this excellent week-to-week reproducibility of PWV. The method provides a simple, easily-obtainable, and reproducible measurement of PWV in young and middle-aged subjects, and has potential to detect premature arterial aging for the management of primary prevention.

Download Full-text

Validation of a novel and existing algorithms for the estimation of pulse transit time: advancing the accuracy in pulse wave velocity measurement

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00963.2012 ◽

2013 ◽

Vol 304 (11) ◽

pp. H1558-H1567 ◽

Cited By ~ 38

Author(s):

Orestis Vardoulis ◽

Theodore G. Papaioannou ◽

Nikolaos Stergiopulos

Keyword(s):

Pulse Wave Velocity ◽

Correlation Coefficient ◽

Wave Velocity ◽

Intraclass Correlation Coefficient ◽

Pulse Wave ◽

Intraclass Correlation ◽

Pulse Transit Time ◽

Second Derivative ◽

First Derivative ◽

Accuracy And Precision

The method used for pulse transit time (PTT) estimation critically affects the accuracy and precision of regional pulse wave velocity (PWV) measurements. Several methods of PTT estimation exist, often yielding substantially different PWV values. Since there is no analytic way to determine PTT in vivo, these methods cannot be validated except by using in silico or in vitro models of known PWV and PTT values. We aimed to validate and compare the most commonly used “foot-to-foot” algorithms, namely, the “ diastole-minimum,” “tangential,” “maximum first derivative,” and “maximum second derivative” methods. Also, we propose a new “diastole-patching” method aiming to increase the accuracy and precision in PWV measurements. We simulated 2,000 cases under different hemodynamic conditions using an accurate, validated, distributed, one-dimensional arterial model. The new algorithm detects and “matches” a specific region of the pressure wave foot between the proximal and distal waveforms instead of determining characteristic points. The diastole-minimum and diastole-patching methods showed excellent agreement compared with “real” PWV values of the model, as indicated by high values of the intraclass correlation coefficient (>0.86). The diastole-patching method resulted in low bias (absolute mean difference: 0.26 m/s). In contrast, PWV estimated by the maximum first derivative, maximum second derivative, and tangentia methods presented low to moderate agreement and poor accuracy (intraclass correlation coefficient: <0.79 and bias: >0.9 m/s). The diastole-patching method yielded PWV measurements with the highest agreement, accuracy, and precision and lowest variability.

Download Full-text

STRUCTURAL AND FUNCTIONAL VASCULAR CHANGES IN HIGH NORMAL ARTERIAL PRESSURE

BULGARIAN JOURNAL OF VETERINARY MEDICINE ◽

10.15547//tjs.2020.01.002 ◽

2020 ◽

Vol 23 (1) ◽

pp. 7-11

Author(s):

P. Nikolov

Keyword(s):

Arterial Pressure ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Pressure ◽

Pulse Wave ◽

Augmentation Index ◽

Aortic Pressure ◽

Large Arteries ◽

Central Aortic Pressure ◽

Significant Difference

The PURPUSE of the present study is changes in function and structure of large arteries in individuals with High Normal Arterial Pressure (HNAP) to be established. MATERIAL and METHODS: Structural and functional changes in the large arteries were investigated in 80 individuals with HNAP and in 45 with optimal arterial pressure (OAP). In terms of arterial stiffness, pulse wave velocity (PWV), augmentation index (AI), central aortic pressure (CAP), pulse pressure (PP) were followed up in HNAP group. Intima media thickness (IMT), flow-induced vasodilatation (FMD), ankle-brachial index (ABI) were also studied. RESULTS: Significantly increased values of pulse wave velocity, augmentation index, central aortic pressure, pulse pressure are reported in the HNAP group. In terms of IMT and ABI, being in the reference interval, there is no significant difference between HNAP and OAP groups. The calculated cardiovascular risk (CVR) in both groups is low. CONCLUSION: Significantly higher values of pulse wave velocity, augmentation index, central aortic pressure and pulse pressure in the HNAP group are reported.

Download Full-text

Short-term atorvastatin therapy improves arterial stiffness of middle-aged systemic lupus erythematosus patients with pathological pulse wave velocity

Lupus ◽

10.1177/0961203316662719 ◽

2016 ◽

Vol 26 (4) ◽

pp. 355-364 ◽

Cited By ~ 9

Author(s):

R Castejon ◽

A Castañeda ◽

A Sollet ◽

S Mellor-Pita ◽

P Tutor-Ureta ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Arterial Stiffness ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Lupus Erythematosus ◽

Pulse Wave ◽

Middle Aged ◽

Systemic Lupus ◽

Short Term ◽

Atorvastatin Therapy

Download Full-text

Association between pulse wave velocity and hot flashes/sweats in middle-aged women

Scientific Reports ◽

10.1038/s41598-017-13395-z ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 3

Author(s):

Ruwei Yang ◽

Yang Zhou ◽

Changbin Li ◽

Minfang Tao

Keyword(s):

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Hot Flashes ◽

Middle Aged

Download Full-text

Effects of Pomegranate Juice Supplementation on Pulse Wave Velocity and Blood Pressure in Healthy Young and Middle-aged Men and Women

Plant Foods for Human Nutrition ◽

10.1007/s11130-012-0295-z ◽

2012 ◽

Vol 67 (3) ◽

pp. 309-314 ◽

Cited By ~ 45

Author(s):

Anthony Lynn ◽

Hiba Hamadeh ◽

Wing Chi Leung ◽

Jean M. Russell ◽

Margo E. Barker

Keyword(s):

Blood Pressure ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Pomegranate Juice ◽

Middle Aged ◽

Men And Women

Download Full-text

Association Between Erectile Dysfunction and Asymptomatic Cardiovascular Damage in Middle-Aged Men

Medicina ◽

10.3390/medicina49120080 ◽

2014 ◽

Vol 49 (12) ◽

pp. 80 ◽

Cited By ~ 1

Author(s):

Vilma Dženkevičiūtė ◽

Žaneta Petrulionienė ◽

Virginijus Šapoka ◽

Vytautas Kasiulevičius

Keyword(s):

Erectile Dysfunction ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Atherosclerotic Plaque ◽

Erectile Function ◽

Pulse Wave ◽

Middle Aged ◽

Early Marker ◽

Cv Disease ◽

Plaque Count

Background and Objective. It has been proposed that the same cardiovascular risk (CV) factors predispose middle-aged men to the development of both coronary artery disease and erectile dysfunction (ED). Moreover, several recently published studies have identified ED as a possible early marker of CV disease. The aim of this particular study was to evaluate the association between ED and early asymptomatic heart and vascular damage in middle-aged men with CV risk factors. Material and Methods. In this case-control study, the International Index of Erectile Function (IIEF) questionnaire was employed to assess the erectile function of the study participants and to allocate them either into the ED group (N=21; mean IIEF score, 18.15 [SD, 2.54]; mean age, 48.2 years [SD, 4.4]) or the control group (N=24; mean IIEF score, 23.45 [SD, 0.99]; mean age, 46.8 years [SD, 3.1]). Additionally, pulse wave velocity, augmentation index, pulse pressure, carotid intima media thickness (IMT), and atherosclerotic plaque count were determined, and echocardiography was performed in every subject. Results. The mean IMT and left ventricular mass index (LVMI) of both carotid arteries in the ED group were significantly higher when compared with controls (598.57 vs. 535.54 mm·10–3, P=0.03, and 107.26 vs. 98.67 g/m2, P=0.04, respectively). Using multiple regression analysis, an independent association between the IIEF score and the LVMI was found (P=0.002). No significant differences in the results of pulse wave velocity, atherosclerotic plaque count, and other laboratory tests were found between the 2 study groups. Conclusions. The study suggests that ED is associated with a higher LVMI and may be an early marker of CV disease.

Download Full-text

Biomechanics and Blood Pressure with Modeling of Pulse Wave Velocity Based on Multiple Linear Regression

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.952.261 ◽

2014 ◽

Vol 952 ◽

pp. 261-264

Author(s):

Long Jia

Keyword(s):

Blood Pressure ◽

Linear Regression ◽

Pulse Wave Velocity ◽

Regression Model ◽

Multiple Linear Regression ◽

Wave Velocity ◽

Pulse Wave ◽

Model Assessment ◽

Practical Test ◽

Significant Difference

The purpose of present study is to build a multiple linear regression model using biomechanical theory to assess the relationship of pulse wave velocity (PWV) with blood pressure, height and age. By testing the PWV, blood pressure, height, weight of 164 female adults aged above 45 and existing data, the author constructed a multiple linear regression equation. Through comparing the practical test PWV values with the estimate values from regression model, the result showed that there was no significant difference between the model assessment and practical test values (t=0.833, p=.423>.05). Therefore, the regression model is fit for assessing PWV value by height, age, systolic and diastolic pressure.

Download Full-text