Update of the situation of clinical photodynamic therapy in Europe in the 2003–2018 period

2019 ◽  
Vol 23 (04n05) ◽  
pp. 347-357 ◽  
Author(s):  
Céline Frochot ◽  
Serge Mordon
Keyword(s):  
European Union ◽  
Clinical Trials ◽  
Photodynamic Therapy ◽  
Clinical Study ◽  
Clinical Studies ◽  
European Countries ◽  
The European Union ◽  
Critical Importance ◽  
Unknown Status ◽  
Study Completion

Photodynamic therapy has become of interest in many European countries. Since, most of national authorities and all medical journals require the registration of the clinical study on the database ClinicalTrials. gov in order to be published, information regarding clinical studies are now available. This article aims to synthetize data gathered thanks to this database. The keywords used for this analysis was: (i) status: “All studies “(recruiting, completed, terminated, we did not take into account unknown status), (ii) condition or disease: “Photodynamic Therapy”, (iii) country: name of each European country. Since 2003, 76 clinical trials were registered in Europe. Most clinical studies are performed in Germany (22), France (20) and UK (19). These 3 countries represent 80% of all studies performed in Europe. However 21 European countries have one or more studies on PDT. Clinical studies were mainly performed on skin. Actinic Keratosis treatment (20 studies) represents more than 45% of all studies. 21% were focused on eye, mainly on Age Macular Degeneration (AMD) (8 studies). In 2018, ten (10) clinical trials are in the recruitment phase. On November, 10, 2017, Padeliporfin (STEBA Biotech S.A, Luxembourg) obtained the marketing authorization throughout the European Union. Despite the critical importance of trial registration, compliance with requirements from governmental regulators which mandate the prospective registration of clinical trials has been imperfect. Besides, a large proportion of registry entries are never updated to reflect study completion. However, this review clearly demonstrated that PDT is progressively used in most European countries.

Library and Museum Collections Digitization Projects in Finland

2009 ◽  
pp. 95-100
Author(s):  
Yulia S. Chechikova
Keyword(s):  
European Union ◽  
Cultural Heritage ◽  
European Countries ◽  
Museum Collections ◽  
The European Union ◽  
Scientific Heritage

Digitization of a national cultural and scientific heritage is one of the long-term strategic problems of the European countries’ governments. Member countries of the European Union make major efforts in providing access to their cultural heritage. In the article the process of an access provision is described for Finland.

Money Matters: Dissecting the Relationship Between Gender Equality and Female Homicide Victimization Rates in the European Union

2016 ◽  
Vol 13 (5) ◽  
pp. 435-455 ◽  
Author(s):  
Janet P. Stamatel
Keyword(s):  
European Union ◽  
Gender Equality ◽  
European Countries ◽  
Curvilinear Relationship ◽  
Violent Victimization ◽  
The European Union ◽  
Homicide Victimization ◽  
The Relationship ◽  
Gender Specific ◽  
Victimization Rates

This study utilized a fairly new measure of gender equality from the European Union to dissect the relationship between gender-specific homicide victimization rates and different forms of gender equality across a sample of European countries. Results showed support for a curvilinear relationship between financial equality and female and male homicide victimization, providing support for amelioration and backlash theories, but no support for absolute economic marginalization. While there were some similarities between the female and male models, there were enough differences to warrant further investigations of gendered theories of violent victimization.

Development of European Union and joining perspective of Croatia

2007 ◽  
Vol 13 (2) ◽  
pp. 507-514
Author(s):  
Ivan Vuković
Keyword(s):  
European Union ◽  
Monetary Policy ◽  
Security Policy ◽  
Technological Development ◽  
Developed Countries ◽  
European Countries ◽  
The European Union ◽  
Demographic Development ◽  
The World ◽  
The Eu

In this paper we researched European Union starting with the Agreement from Maastrich from year 1992, even though the European Union has a long traditional history and its origin is founded on regulations of economical integrations in Europe beginning from the 1950’s through the Roman treaty from year 1957 and the forming of the European Union Committee in year 1965. Further we follow her expansion and introduction of the European economic and monetary policy, to last, the joining perspective of Croatia. According to the Agreement from Maastrich, European Union lies on three posts: 1) Legal-political and regulative post, 2) Economical post, where the forming of European economical and monetary policy is in the first plan, especially the introducing of Euro as the unique European currency, 3) Post of Mutual foreign security policy within European Union. In that context we need to highlight the research conducted here and in European Union, including the world, regarding development of European Union and its economical, legal, political and cultural, as well as foreign diplomatic results, which are all perspectives of European Union. All the scientists and researches which were involved in exploring the development of EU with its modern tendencies and development perspective, agree that extraordinary results are achieved regards to economical, legal, political, foreign-security and diplomatic views, even tough many repercussions exist in progress of some particular members and within the EU as a whole. The biggest controversy arises in the perspective and expanding of European Union regarding ratification of the Constitution of EU from particular country members, but especially after the referendum was refused from two European countries, France and Netherlands. According to some estimates, the Constitution of EU would have difficulty to be adopted in Switzerland and some other Scandinavian countries, but also in Great Britain and other very developed countries. However the European Community and European Union were developing and expanding towards third European countries, regardless of Constitutional non-existence, where we can assume that if and when the Constitution of EU will be ratified, the EU will further develop as one of the most modern communities. This will enable economical development, especially development of European business, unique European market and free trade of goods and services, market of financial capital and labour market in free movement of labour. Being that EU has become one of the most largest dominating markets in the world, it offers a possibility to all new members to divide labour by using modern knowledge and high technology which insure economical, social and political prosperity. This results to forming a society of European countries which will guarantee all rights and freedom of development for all nations and ethnic groups. As well as, all European countries with somewhat less sovereignty, but in international relations will be stronger and significant, not only in sense of economics, but also in politics and military diplomatic relations. Therefore, Croatia has no choice and perspective if she does not join the European Union till year 2010, but until than it needs to create its strategy of economical and scientific-technological development, including demographic development, which will insure equal progress of Croatia as an equal member of European Union.

Prospects for European Integration of the Republic of Moldova and the Constitutional Component

2021 ◽  
pp. 84-89
Author(s):  
K. Gylka
Keyword(s):  
European Union ◽  
European Economic Community ◽  
European Countries ◽  
Minority Languages ◽  
The European Union ◽  
Economic Community ◽  
European Continent ◽  
European Economic ◽  
Economic Relations ◽  
The Republic

The European Union (EU) is an economic and political union of 28 European countries. The population is 508 million people, 24 official and working languages and about 150 regional and minority languages. The origins of the European Union come from the European Coal and Steel Community (ECSC) and the European Economic Community (EEC), consisting of six states in 1951 - Belgium, France, Germany, Italy, Luxembourg and the Netherlands. These countries came together to put an end to the wars that devastated the European continent, and they agreed to share control over the natural resources needed for war (coal and steel). The founding members of ECSC have determined that this European project will not only be developed in order to share resources or to prevent various conflicts in the region. Thus, the Rome Treaty of 1957 created the European Economic Community (EEC), which strengthened the political and economic relations between the six founding states. The relevance of the topic stems from their desire of peoples and countries to live better. The purpose of the study is to identify the internal and external development mechanisms of European countries and, on this basis, to formulate a model of economic, legislative and social development for individual countries. The results of the study provide a practical guideline for determining the vector of the direction of efforts of political, economic, legislative, humanitarian, etc.

scholarly journals EMEA and Gene Therapy Medicinal Products Development in the European Union

2003 ◽  
Vol 2003 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Marisa Papaluca Amati ◽  
Francesco Pignatti ◽  
Alexis Nolte ◽  
Nirosha Amerasinghe ◽  
Daniel Gustafsson ◽  
...  
Keyword(s):  
Gene Therapy ◽  
European Union ◽  
Clinical Trials ◽  
Good Clinical Practice ◽  
Evaluation Agency ◽  
The European Union ◽  
Medicinal Products ◽  
Regulatory Processes ◽  
National Competent Authorities ◽  
Practice Implementation

The evaluation of quality, safety, and efficacy of medicinal products by the European Medicines Evaluation Agency (EMEA) via the centralized procedure is the only available regulatory procedure for obtaining marketing authorization for gene therapy (GT) medicinal products in the European Union. The responsibility for the authorization of clinical trials remains with the national competent authorities (NCA) acting in a harmonized framework from the scientific viewpoint. With the entry into force of a new directive on good clinical practice implementation in clinical trials as of 1 May 2004, procedural aspects will also be harmonized at EU level. Scientifically sound development of medicinal products is the key for the successful registration of dossiers and for contributing to the promotion and protection of public health. The objective of this paper is to introduce the EMEA regulatory processes and scientific activities relevant to GT medicinal products.

scholarly journals New regulation for clinical trials in the European Union: review and discussion

2019 ◽  
Vol 1 (30) ◽  
pp. 26-32
Author(s):  
Bakhyt Sarymsakova ◽  
◽  
Gaukhar Kuanova ◽  
Keyword(s):  
European Union ◽  
Clinical Trials ◽  
The European Union

scholarly journals International legal experience in combating illegal migration by sea

2021 ◽  
Vol 66 ◽  
pp. 284-287
Author(s):  
O.O. Kukshynova ◽  
A. O. Samoilenko
Keyword(s):  
European Union ◽  
Legal Framework ◽  
Legal Regulation ◽  
European Countries ◽  
The European Union ◽  
Illegal Migration ◽  
Illegal Migrants ◽  
Theoretical Approaches ◽  
The Impact ◽  
Treaty Of Amsterdam

This article highlights the impact of international law on the global process of illegal migration, reveals a number of international problems related to international migration, in particular by sea, identifies the main factors influencing illegal migration in general, indicates the state of illegal migration in various European Union countries. attention is paid to such important international legal instruments as the Schengen Agreement of 1985 and 1990, the Dublin Convention of 1990, the Maastricht Treaty of 1992 and the Treaty of Amsterdam of 1997. The article also focuses on the European Union agency, which deals with the protection of external borders and their protection from illegal migrants, in particular, by sea.The analysis of theoretical and practical aspects of combating illegal migration by sea at the international level, as well as in the development of scientific and theoretical approaches to solving migration problems, characterizes the legal regulation of combating illegal migration by maritime transport and maritime participation established intergovernmental bodies. The main tools of the European Union to combat illegal migration by sea, which can be used to improve the legal regulation of migration authorities of other countries, as well as substantiate the organizational and legal framework of European countries in the field of legal support to combat illegal migration by sea.The actions of European states represented by the relevant state bodies in solving the problems of illegal migration with the help of merchant fleets of European countries are studied. The article pays attention to the influence of illegal migration on the formation and change of legal awareness of society, as the beginning of the formation of criminogenic factors among illegal migrants in the host country.

scholarly journals Acquisition practice prior to commercial use in the European Union

2012 ◽  
pp. 153-158
Author(s):  
Ágnes Barbara Berde
Keyword(s):  
European Union ◽  
Research Programme ◽  
European Countries ◽  
Special Role ◽  
The European Union ◽  
Pilot Projects ◽  
Business Innovation ◽  
Innovation Research ◽  
New Methods ◽  
Europe 2020

The target of 3% of GDP spent on R&D by the Lisbon priorities seems to be still far away from the reality in some European countries and at EU level as well. The economic crisis determined the priorities and it makes more complicated to dedicate more budget on Research and Development. New methods, new measures are needed in the European Union. Measures that supporting the demand side of the innovation and generates market-pull affects. The Europe 2020 Innovation Union Flagship Initiative dedicates a special role to precommercial procurement for the upcoming 10 years. Nowadays, there are more and more European countries running pilot projects adapting the American SBIR (Small Business Innovation Research) programme.

Sign in / Sign up

Export Citation Format

Share Document