A HYBRID GENETIC ALGORITHM FOR THE MAXIMUM LIKELIHOOD ESTIMATION OF MODELS WITH MULTIPLE EQUILIBRIA: A FIRST REPORT

2005 ◽  
Vol 01 (02) ◽  
pp. 295-303 ◽  
Author(s):  
VICTOR AGUIRREGABIRIA ◽  
PEDRO MIRA
Keyword(s):  
Genetic Algorithm ◽  
Maximum Likelihood ◽  
Multiple Equilibria ◽  
Structural Parameters ◽  
Hybrid Genetic Algorithm ◽  
Likelihood Estimation ◽  
Maximum Likelihood Estimates ◽  
Large Space ◽  
Pseudo Maximum Likelihood ◽  
Structural Econometric

This paper presents a hybrid genetic algorithm to obtain maximum likelihood estimates of parameters in structural econometric models with multiple equilibria. The algorithm combines a pseudo maximum likelihood (PML) procedure with a genetic algorithm (GA). The GA searches globally over the large space of possible combinations of multiple equilibria in the data. The PML procedure avoids the computation of all the equilibria associated with every trial value of the structural parameters.

scholarly journals Directional Selection and the Site-Frequency Spectrum

Genetics ◽  
2001 ◽  
Vol 159 (4) ◽  
pp. 1779-1788 ◽  
Author(s):  
Carlos D Bustamante ◽  
John Wakeley ◽  
Stanley Sawyer ◽  
Daniel L Hartl
Keyword(s):  
Maximum Likelihood ◽  
High Power ◽  
Negative Selection ◽  
Likelihood Estimation ◽  
Directional Selection ◽  
Likelihood Ratio Tests ◽  
Maximum Likelihood Estimates ◽  
Likelihood Methods ◽  
Ancestral States ◽  
Asymptotic Variances

Abstract In this article we explore statistical properties of the maximum-likelihood estimates (MLEs) of the selection and mutation parameters in a Poisson random field population genetics model of directional selection at DNA sites. We derive the asymptotic variances and covariance of the MLEs and explore the power of the likelihood ratio tests (LRT) of neutrality for varying levels of mutation and selection as well as the robustness of the LRT to deviations from the assumption of free recombination among sites. We also discuss the coverage of confidence intervals on the basis of two standard-likelihood methods. We find that the LRT has high power to detect deviations from neutrality and that the maximum-likelihood estimation performs very well when the ancestral states of all mutations in the sample are known. When the ancestral states are not known, the test has high power to detect deviations from neutrality for negative selection but not for positive selection. We also find that the LRT is not robust to deviations from the assumption of independence among sites.

scholarly journals The Weibull Birnbaum-Saunders Distribution And Its Applications

2020 ◽  
Vol 9 (1) ◽  
pp. 61-81
Author(s):  
Lazhar BENKHELIFA
Keyword(s):  
Maximum Likelihood ◽  
Estimation Method ◽  
Likelihood Estimation ◽  
Real Data ◽  
Reliability Estimation ◽  
Maximum Likelihood Estimates ◽  
Model Parameters ◽  
Data Sets ◽  
Proposed Model ◽  
Modeling Data

A new lifetime model, with four positive parameters, called the Weibull Birnbaum-Saunders distribution is proposed. The proposed model extends the Birnbaum-Saunders distribution and provides great flexibility in modeling data in practice. Some mathematical properties of the new distribution are obtained including expansions for the cumulative and density functions, moments, generating function, mean deviations, order statistics and reliability. Estimation of the model parameters is carried out by the maximum likelihood estimation method. A simulation study is presented to show the performance of the maximum likelihood estimates of the model parameters. The flexibility of the new model is examined by applying it to two real data sets.

MLML2R: an R package for maximum likelihood estimation of DNA methylation and hydroxymethylation proportions

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Samara F. Kiihl ◽  
Maria Jose Martinez-Garrido ◽  
Arce Domingo-Relloso ◽  
Jose Bermudez ◽  
Maria Tellez-Plaza
Keyword(s):  
Dna Methylation ◽  
Maximum Likelihood ◽  
Likelihood Estimation ◽  
Analytical Form ◽  
R Package ◽  
Maximum Likelihood Estimates ◽  
Computational Time ◽  
Iterative Approximation ◽  
Sequencing Technologies ◽  
Combining Data

Abstract Accurately measuring epigenetic marks such as 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) at the single-nucleotide level, requires combining data from DNA processing methods including traditional (BS), oxidative (oxBS) or Tet-Assisted (TAB) bisulfite conversion. We introduce the R package MLML2R, which provides maximum likelihood estimates (MLE) of 5-mC and 5-hmC proportions. While all other available R packages provide 5-mC and 5-hmC MLEs only for the oxBS+BS combination, MLML2R also provides MLE for TAB combinations. For combinations of any two of the methods, we derived the pool-adjacent-violators algorithm (PAVA) exact constrained MLE in analytical form. For the three methods combination, we implemented both the iterative method by Qu et al. [Qu, J., M. Zhou, Q. Song, E. E. Hong and A. D. Smith (2013): “Mlml: consistent simultaneous estimates of dna methylation and hydroxymethylation,” Bioinformatics, 29, 2645–2646.], and also a novel non iterative approximation using Lagrange multipliers. The newly proposed non iterative solutions greatly decrease computational time, common bottlenecks when processing high-throughput data. The MLML2R package is flexible as it takes as input both, preprocessed intensities from Infinium Methylation arrays and counts from Next Generation Sequencing technologies. The MLML2R package is freely available at https://CRAN.R-project.org/package=MLML2R.

ADAPTIVE ESTIMATION OF ERROR CORRECTION MODELS

1998 ◽  
Vol 14 (1) ◽  
pp. 44-69 ◽  
Author(s):  
Douglas J. Hodgson
Keyword(s):  
Maximum Likelihood ◽  
Error Correction ◽  
Adaptive Estimation ◽  
Kernel Estimation ◽  
Likelihood Estimation ◽  
Error Correction Models ◽  
Estimation Of Error ◽  
Vector Error Correction Models ◽  
Pseudo Maximum Likelihood ◽  
Nonparametric Kernel

This paper considers adaptive maximum likelihood estimation of reduced rank vector error correction models. It is shown that such models can be asymptotically efficiently estimated even in the absence of knowledge of the shape of the density function of the innovation sequence, provided that this density is symmetric. The construction of the estimator, involving the nonparametric kernel estimation of the unknown density using the residuals of a consistent preliminary estimator, is described, and its asymptotic distribution is derived. Asymptotic efficiency gains over the Gaussian pseudo–maximum likelihood estimator are evaluated for elliptically symmetric innovations.

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