The Structure and Release Kinetics of Ca–Al Layered Double Hydroxide by Intercalating with Diclofenac Sodium

NANO ◽  
2020 ◽  
Vol 15 (03) ◽  
pp. 2050028
Author(s):  
Yingying Ma ◽  
Shuhua Zhang ◽  
Yu Wang ◽  
Zhenlin Jiang ◽  
Nengshuo Fu ◽  
...  
Keyword(s):  
Side Effects ◽  
Layered Double Hydroxide ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Diclofenac Sodium ◽  
Basal Spacing ◽  
Release Kinetic ◽  
Edge Structure ◽  
X Ray ◽  
Double Hydroxide

Diclofenac sodium (DS) is an aryl acetic acid nonsteroidal anti-inflammatory drug which is widely used in various types of chronic bone and joint pains, but its terminal plasma half life is short, often accompanied with gastrointestinal side effects. We try to find an inexpensive and effective drug carrier to prolong the administration interval, maintain a stable blood concentration and reduce side effects. In our work, DS had been intercalated into a layered inorganic host, Ca–Al layered double hydroxide (LDH) by co-precipitation under a nitrogen atmosphere to control the release. X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) and transmission electron microscope (TEM) were used to investigate the change of chemical structure and morphological structure when DS was inserted into the interlayer of LDH. X-ray photoelectron spectroscopy (XPS) and X-ray absorption near edge structure (XANES) were employed to characterize the electron binding energy of calcium and aluminum cations both on the surface and in the bulk of the samples. The results of absorption peaks, morphologies and the basal spacing increased from 8.6[Formula: see text]Å to 29.59[Formula: see text]Å gave the evidences for the intercalation of DS into the interlayer of CaAl-LDH. The results of XPS and XANES spectra revealed the complexation of –OH and [Formula: see text] with Ca[Formula: see text] and Al[Formula: see text] were both were affected by the loading of DS with CaAl-LDH, but no new chemical bonds were formed. Inductively coupled plasma optical emission spectroscopy (ICP-OES) analysis showed the dissolving process of Ca and Al ions from CaAl-LDH in the solution. In addition, the results of the drug release profile and release kinetic of intercalated LDHs showed that release behavior of DS from intercalated compounds was well controlled.

scholarly journals Synthesis and Characterization of Layered-Double Hydroxide 3-(4-Hydroxyphenyl) Propionate Nanocomposite

Nano Hybrids ◽  
2014 ◽  
Vol 7 ◽  
pp. 53-67 ◽  
Author(s):  
Ahmad Siti Nurasikin ◽  
Hashim Norhayati ◽  
Nur Hidayah Yusri ◽  
Illyas Md Isa ◽  
Azlan Kamari ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Layered Double Hydroxide ◽  
Ftir Spectra ◽  
Basal Spacing ◽  
Exchange Method ◽  
X Ray ◽  
Ion Exchange Method ◽  
Double Hydroxide ◽  
Thermal Stability Of

A new layered-double hydroxide-3-(4-hydroxyphenyl) propionate (LDH-HPP) has been synthesized by intercalation of 3-(4-hydroxyphenyl) propionic acid (HPP) into Zn-Al-layered double hydroxide (LDH) by ion-exchange method. PXRD, FTIR, TGA/DTG, compositional studies and FESEM were used to characterize the synthesized nanocomposite. The intercalation of HPP into the interlayer gallery space of LDH was characterized by x-ray diffractogram showed expanded basal spacing of the value of 17.1 Å. The FTIR spectra of LDH-HPP nanocomposite synthesis by 0.025M HPP resembled a mixture of both FTIR spectra of HPP and LDH. Thermal analysis of LDH-HPP nanocomposite shows a better thermal stability as compared to the pure HPP, which proved that the intercalation of HPP into LDH interlayer enhanced the thermal stability of the HPP.

scholarly journals Homogeneous Incorporation of Gallium into Layered Double Hydroxide Lattice for Potential Radiodiagnostics: Proof-of-Concept

Nanomaterials ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 44
Author(s):  
Do-Gak Jeung ◽  
Tae-Hyun Kim ◽  
Jae-Min Oh
Keyword(s):  
Electron Microscopy ◽  
Layered Double Hydroxide ◽  
Inductively Coupled Plasma ◽  
Hydrothermal Reaction ◽  
Edge Structure ◽  
X Ray ◽  
Inductively Coupled ◽  
Diffraction Patterns ◽  
Double Hydroxide ◽  
X Ray Absorption

Trivalent gallium ion was successfully incorporated into chemically well-defined MgAl-layered double hydroxide (LDH) frameworks through postsynthetic hydrothermal treatment. Quantitative analysis with inductively coupled plasma-mass spectroscopy exhibited that Ga3+ was first incorporated into LDH through partial dissolution-precipitation at the edge of LDH particle and homogeneously distributed throughout the particle by substitution of Ga3+ for Al3+ in LDH frame works. The powder X-ray diffraction patterns showed that the Ga3+ incorporation did not affect the crystal structure without evolution of unexpected impurities. The morphology and surface property of LDH evaluated by scanning electron microscopy and light scattering showed the preservation of physicochemical properties throughout 24 h of hydrothermal reaction. The distribution of incorporated Ga3+ was visualized with energy dispersive spectroscopy-assisted transmission electron microscopy, suggesting the homogeneous location of Ga3+ in an LDH particle. The X-ray absorption near-edge structure and extended X-ray absorption fine structure suggested that the Ga moiety was immobilized in LDH from 0.5 h and readily crystallized upon reaction time.

A square planar [NiCl4]2− ion in the layered double hydroxide Al2Li(OH)6 [NiCl4]1/2

Clay Minerals ◽  
1997 ◽  
Vol 32 (2) ◽  
pp. 299-305 ◽  
Author(s):  
K. Okada ◽  
F. Matsushita ◽  
S. Hayashi
Keyword(s):  
Layered Double Hydroxide ◽  
Basal Spacing ◽  
Hexagonal Cell ◽  
Tetrahedral Structure ◽  
X Ray ◽  
Square Planar ◽  
Spin Resonance ◽  
Double Hydroxide ◽  
X Ray Absorption ◽  
No Absorption

AbstractThe layered double hydroxide (LDH) Al2Li(OH)6[NiCl4]1/2 was synthesized by anion exchange of Al2Li(OH)6(NO3) and the coordination structure of [NiCl4]2− in the interlayers was investigated. The LDH had a hexagonal cell with a = 5.06 and c = 23.06 Å. Since the basal spacing of one layer was 7.7 Å, the interlayer distance was calculated to be 2.9 Å and was too narrow for the usual tetrahedral NiCl4 structure. From extended X-ray absorption fine structure (EXAFS) measurements, the first neighbour Ni-Cl distances in the LDH were 2.10 Å which was compatible with four-fold coordination. Since the electron spin resonance (ESR) spectrum of the LDH showed no absorption, the [NiCl4]2− structure was considered to be square planar, rather than the usual tetrahedral structure in the interlayers of LDH.

scholarly journals Effects of polymer intercalation in calcium silicate hydrates on drug loading capacities and drug release kinetics: an X-ray absorption near edge structure study

2017 ◽  
Vol 95 (11) ◽  
pp. 1122-1129 ◽  
Author(s):  
Xiaoxuan Guo ◽  
Jin Wu ◽  
Yun-Mui Yiu ◽  
Yongfeng Hu ◽  
Ying-Jie Zhu ◽  
...  
Keyword(s):  
Drug Release ◽  
Calcium Silicate ◽  
Release Kinetics ◽  
Drug Carrier ◽  
Drug Loading ◽  
Precipitation Reaction ◽  
Edge Structure ◽  
X Ray ◽  
Drug Release Kinetics ◽  
X Ray Absorption

Different calcium silicate hydrate (CSH)/polymer composites are synthesized by using a controlled precipitation reaction between calcium salt and silicate salt, followed by the addition of various polymer solutions at room temperature. X-ray absorption near edge structure (XANES) spectroscopy has been used to extensively investigate the structural changes after hybrid biomaterials formation and the drug–carrier interactions on the molecular level. We find that the polymers alter the structure of CSH to various degrees and that this behaviour further influences the drug loading capacities and drug release kinetics.

GRAFTING INTERLAYER MoO42- IN Mg/Al LAYERED DOUBLE HYDROXIDE BY THERMAL TREATMENT BELOW COLLAPSING THE LAYERED STRUCTURE

2012 ◽  
Vol 06 ◽  
pp. 127-132
Author(s):  
Kennichi Muranishi ◽  
Akihiro Shimamura ◽  
Masashi Kurashina ◽  
Eiji Kanezaki
Keyword(s):  
Thermal Analysis ◽  
Differential Thermal Analysis ◽  
Thermal Treatment ◽  
Layered Double Hydroxide ◽  
Interlayer Spacing ◽  
Basal Spacing ◽  
X Ray Diffraction ◽  
X Ray ◽  
Interlayer Anion ◽  
Double Hydroxide

Some kinds of Mg / Al layered double hydroxide (LDH) with oxometalate have been prepared by mean of anion exchange. Products were characterized by powder X-ray diffraction (XRD), chemical analysis and Thermogravimetry - Differential Thermal Analysis (TG-DTA). Results showed that the basal spacing of heated LDH decreased with heating to 300 °C. This revealed the decrease of interlayer spacing and the interlayer anion being grafted to the layer of LDH because the decreased interlayer spacing of the heated LDH was smaller than the size of the interlayer anion.

Design of An electrochemical platform for Determination of Diclofenac Sodium utilizing a Graphenized Pencil Graphite Electrode Modified with Cu-Al Layered Double Hydroxide/ Chicken Feet Yellow Membrane

2021 ◽  
Author(s):  
Younes Bahadori ◽  
Habib Razmi
Keyword(s):  
Electrochemical Sensor ◽  
Layered Double Hydroxide ◽  
Graphite Electrode ◽  
Diclofenac Sodium ◽  
Pencil Graphite Electrode ◽  
Double Hydroxide

A novel electrochemical sensor based on the Cu-Al layered double hydroxide (Cu-Al LDH) by chicken feet yellow membrane (CFYM) on graphenized pencil graphite electrode (GPGE) was designed. The present modified...

scholarly journals Ion Exchange of Benzoate in Ni-Al-Benzoate Layered Double Hydroxide by Amoxicillin

2019 ◽  
Vol 17 (1) ◽  
pp. 1043-1049
Author(s):  
Dian Windy Dwiasi ◽  
Mudasir Mudasir ◽  
Roto Roto
Keyword(s):  
Ion Exchange ◽  
Anion Exchange ◽  
Layered Double Hydroxide ◽  
Exchange Process ◽  
X Ray ◽  
Batch Technique ◽  
Pseudo Second Order ◽  
Ft Ir ◽  
Double Hydroxide ◽  
Benzoate Anion

AbstractThe Ni-Al-NO3 layered double hydroxide (LDH) compound has been intercalated with benzoate anion through an anion exchange process for amoxicillin drug adsorption. The purpose of this research is to synthesize Ni-Al-NO3, ion exchange with benzoate anion to form Ni-Al-Benzoate, and then applying it as an adsorbent of amoxicillin. The adsorption process was carried out using the batch technique. The materials synthesized in this study were characterized by Fourier Transform Infrared Spectroscopy (FT-IR), X-ray ray diffraction (XRD), and Thermogravimetric Analysis/Differential Thermal Analysis (TGA/DTA). The exchange of benzoate in Ni-Al-Benzoate LDH by amoxicillin was followed by UV-Vis spectrophotometry. The pH, LDH amount, and contact time are optimized. The adsorption of amoxicillin by Ni-Al-Benzoate is fit to the pseudo-second-order kinetics model, with an adsorption capacity of 40 mg/ g. The results showed that anion exchange was successfully carried out between benzoate anion and amoxicillin.

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