scholarly journals NUMERICAL INVESTIGATION OF THE RELEASE OF DRUG FROM A DRUG-DELIVERY DEVICE

2012 ◽  
Vol 09 ◽  
pp. 119-126
Author(s):  
M. GARSHASBI ◽  
H. KAMAL GHARIBI
Keyword(s):  
Drug Delivery ◽  
Moving Boundary ◽  
Numerical Solutions ◽  
The Body ◽  
Moving Boundary Problem ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Finite Differences Method ◽  
Dominant Process ◽  
Drug Delivery Devices

In this study a mathematical model for the release of drug from porous, nonswelling transdermal drug-delivery devices to a perfect sink is considered. The drug is postulated to diffuse in both the solvent-filled pores and the body of the polymer. The limit in which the dissolution of drug is the dominant process is considered and a moving boundary problem governing drug release is derived. This model is solved numerically under some spacial conditions. Furthermore, another limit case in which the dissolution process is not so rapid is investigated and analytical and numerical solutions based on Fourier series solution and finite differences method are derived. Finally, the numerical and analytical solutions are compared to show the ability of the proposed numerical procedures.

scholarly journals Mathematical Model for Estimating Parameters of Swelling Drug Delivery Devices in a Two-Phase Release

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2921
Author(s):  
Amanina Setapa ◽  
Naveed Ahmad ◽  
Shalela Mohd Mahali ◽  
Mohd Cairul Iqbal Mohd Amin
Keyword(s):  
Mathematical Model ◽  
Drug Delivery ◽  
Diffusion Coefficient ◽  
Drug Release ◽  
Effective Diffusion Coefficient ◽  
Moving Boundary ◽  
Effective Diffusion ◽  
Moving Boundary Problem ◽  
Two Phase ◽  
Drug Delivery Devices

Various swelling drug delivery devices are promising materials for control drug delivery because of their ability to swell and release entrapped therapeutics, in response to physiological stimuli. Previously, many mathematical models have been developed to predict the mechanism of drug release from a swelling device. However, some of these models do not consider the changes in diffusion behaviour as the device swells. Therefore, we used a two-phase approach to simplify the mathematical model considering the effect of swelling on the diffusion coefficient. We began by defining a moving boundary problem to consider the swelling process. Landau transformation was used for mitigating the moving boundary problem. The transformed problem was analytically solved using the separation of variables method. Further, the analytical solution was extended to include the drug release in two phases where each phase has distinct diffusion coefficient and continuity condition was applied. The newly developed model was validated by the experimental data of bacterial cellulose hydrogels using the LSQCURVEFIT function in MATLAB. The numerical test showed that the new model exhibited notable improvement in curve fitting, and it was observed that the initial effective diffusion coefficient of the swelling device was lower than the later effective diffusion coefficient.

scholarly journals Novel Drug Delivery Device Using Silicone: Controlled Release of Insoluble Drugs or Two Kinds of Water-Soluble Drugs

2003 ◽  
Vol 51 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Masako Kajihara ◽  
Toshihiko Sugie ◽  
Hiroo Maeda ◽  
Akihiko Sano ◽  
Keiji Fujioka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Water Soluble ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Water Soluble Drugs ◽  
Insoluble Drugs ◽  
Novel Drug

An electrochemical intraocular drug delivery device

2008 ◽  
Vol 143 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Po-Ying Li ◽  
Jason Shih ◽  
Ronalee Lo ◽  
Saloomeh Saati ◽  
Rajat Agrawal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Intraocular Drug Delivery

Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers

2007 ◽  
Vol 9 (6) ◽  
pp. 845-853 ◽  
Author(s):  
Won Hyoung Ryu ◽  
Murty Vyakarnam ◽  
Ralph S. Greco ◽  
Fritz B. Prinz ◽  
Rainer J. Fasching
Keyword(s):  
Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Micro Structuring
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