scholarly journals A cost-effective micromilling platform for rapid prototyping of microdevices

TECHNOLOGY ◽  
2016 ◽  
Vol 04 (04) ◽  
pp. 234-239 ◽  
Author(s):  
Daniel P. Yen ◽  
Yuta Ando ◽  
Keyue Shen
Keyword(s):  
Rapid Prototyping ◽  
Low Cost ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Multi Scale ◽  
Organ On A Chip

Micromilling has great potential in producing microdevices for lab-on-a-chip and organ-on-a-chip applications, but has remained under-utilized due to the high machinery costs and limited accessibility. In this paper, we assessed the machining capabilities of a low-cost 3-D mill in polycarbonate material, which were showcased by the production of microfluidic devices. The study demonstrates that this particular mill is well suited for the fabrication of multi-scale microdevices with feature sizes from micrometers to centimeters.

THEORETICAL ANALYSES FOR LASER MACHINING MICROCHANNELS AND DEMONSTRATION OF THEIR USES IN MANUFACTURE OF A MICROFLUIDIC OPTICAL SWITCH

2006 ◽  
Vol 13 (06) ◽  
pp. 795-802 ◽  
Author(s):  
DANIEL LIM ◽  
ERNA GONDO SANTOSO ◽  
KIM MING TEH ◽  
STEPHEN WAN ◽  
H. Y. ZHENG
Keyword(s):  
Fluid Flow ◽  
Optical Switch ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Laser Machining ◽  
Machining Parameters ◽  
Flow Channels ◽  
Cost Effective Method ◽  
Theoretical Analyses

Silicon has been widely used to fabricate microfluidic devices due to the dominance of silicon microfabrication technologies available. In this paper, theoretical analyses are carried out to suggest suitable laser machining parameters to achieve required channel geometries. Based on the analyses, a low-power CO 2 laser was employed to create microchannels in Acrylic substrate for the use of manufacturing an optical bubble switch. The developed equations are found useful for selecting appropriate machining parameters. The ability to use a low-cost CO 2 laser to fabricate microchannels provides an alternative and cost-effective method for prototyping fluid flow channels, chambers and cavities in microfluidic lab chips.

scholarly journals Safe and cost-effective rapid-prototyping of multilayer PMMA microfluidic devices

2016 ◽  
Vol 20 (12) ◽  
Author(s):  
Antonio Liga ◽  
Jonathan A. S. Morton ◽  
Maïwenn Kersaudy-Kerhoas
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Devices ◽  
Cost Effective

scholarly journals Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

TECHNOLOGY ◽  
2017 ◽  
Vol 05 (01) ◽  
pp. 1-12 ◽  
Author(s):  
Aslihan Gokaltun ◽  
Martin L. Yarmush ◽  
Ayse Asatekin ◽  
O. Berk Usta
Keyword(s):  
Rapid Prototyping ◽  
Biomedical Applications ◽  
Gas Permeability ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Mature Stage ◽  
Major Drawback ◽  
Pdms Surface ◽  
Recent Advances ◽  
Hydrophobic Recovery

In the last decade microfabrication processes including rapid prototyping techniques have advanced rapidly and achieved a fairly mature stage. These advances have encouraged and enabled the use of microfluidic devices by a wider range of users with applications in biological separations and cell and organoid cultures. Accordingly, a significant current challenge in the field is controlling biomolecular interactions at interfaces and the development of novel biomaterials to satisfy the unique needs of the biomedical applications. Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. The popularity of this material is the result of its low cost, simple fabrication allowing rapid prototyping, high optical transparency, and gas permeability. However, a major drawback of PDMS is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. This results in significant nonspecific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances in surface molecular treatments to prevent fouling of PDMS surfaces towards improving its utility and expanding its use cases in biomedical applications.

Droplet generation in cross-flow for cost-effective 3D-printed “plug-and-play” microfluidic devices

RSC Advances ◽  
2016 ◽  
Vol 6 (84) ◽  
pp. 81120-81129 ◽  
Author(s):  
Jia Ming Zhang ◽  
Andres A. Aguirre-Pablo ◽  
Er Qiang Li ◽  
Ulrich Buttner ◽  
Sigurdur T. Thoroddsen
Keyword(s):  
Low Cost ◽  
Cross Flow ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Droplet Generation ◽  
Channel Design ◽  
Plug And Play ◽  
3D Printed

Novel low-cost 3D-printed plug-and-play microfluidic devices have been developed for droplet generation and applications. By combining a commercial tubing with the printed channel design we can generate well-controlled droplets down to 50 μm.

scholarly journals Negligible-cost microfluidic device fabrication using 3D-printed interconnecting channel scaffolds

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0245206
Author(s):  
Harry Felton ◽  
Robert Hughes ◽  
Andrea Diaz-Gaxiola
Keyword(s):  
Rapid Prototyping ◽  
Point Of Care ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Microfluidic Devices ◽  
Device Fabrication ◽  
Appropriate Technology ◽  
Channel Cross Section ◽  
Microfluidic Systems ◽  
3D Printed

This paper reports a novel, negligible-cost and open-source process for the rapid prototyping of complex microfluidic devices in polydimethylsiloxane (PDMS) using 3D-printed interconnecting microchannel scaffolds. These single-extrusion scaffolds are designed with interconnecting ends and used to quickly configure complex microfluidic systems before being embedded in PDMS to produce an imprint of the microfluidic configuration. The scaffolds are printed using common Material Extrusion (MEX) 3D printers and the limits, cost & reliability of the process are evaluated. The limits of standard MEX 3D-printing with off-the-shelf printer modifications is shown to achieve a minimum channel cross-section of 100×100 μm. The paper also lays out a protocol for the rapid fabrication of low-cost microfluidic channel moulds from the thermoplastic 3D-printed scaffolds, allowing the manufacture of customisable microfluidic systems without specialist equipment. The morphology of the resulting PDMS microchannels fabricated with the method are characterised and, when applied directly to glass, without plasma surface treatment, are shown to efficiently operate within the typical working pressures of commercial microfluidic devices. The technique is further validated through the demonstration of 2 common microfluidic devices; a fluid-mixer demonstrating the effective interconnecting scaffold design, and a microsphere droplet generator. The minimal cost of manufacture means that a 5000-piece physical library of mix-and-match channel scaffolds (100 μm scale) can be printed for ~$0.50 and made available to researchers and educators who lack access to appropriate technology. This simple yet innovative approach dramatically lowers the threshold for research and education into microfluidics and will make possible the rapid prototyping of point-of-care lab-on-a-chip diagnostic technology that is truly affordable the world over.

Low-cost rapid prototyping and assembly of open microfluidic device for 3D vascularized organ-on-a-chip

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Qinyu Li ◽  
Kai Niu ◽  
Ding Wang ◽  
Lian Xuan ◽  
Xiaolin Wang
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Device ◽  
Biomedical Engineering ◽  
Low Cost ◽  
Human Diseases ◽  
Microfabricated Devices ◽  
Organ On A Chip

Reconstruction of 3D vascularized microtissue within microfabricated devices has rapidly developed in biomedical engineering, which can better mimic tissue microphysiological function and accurately model human diseases in vitro. However, the...

Low-cost rapid prototyping of glass microfluidic devices using a micromilling technique

2018 ◽  
Vol 22 (8) ◽  
Author(s):  
Xiaoyong Ku ◽  
Zongwei Zhang ◽  
Xiaolong Liu ◽  
Li Chen ◽  
Gang Li
Keyword(s):  
Rapid Prototyping ◽  
Low Cost ◽  
Microfluidic Devices
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