scholarly journals Maternal and neonatal response to COVID-19

2020 ◽  
Vol 319 (2) ◽  
pp. E315-E319 ◽  
Author(s):  
Thea N. Golden ◽  
Rebecca A. Simmons
Keyword(s):  
Preterm Birth ◽  
Severe Acute Respiratory Syndrome ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Newborn Health ◽  
Maternal And Newborn Health ◽  
Placental Infection ◽  
Neonatal Response ◽  
Maternal Disease ◽  
Maternal And Newborn

The risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to maternal and newborn health has yet to be determined. Several reports suggest pregnancy does not typically increase the severity of maternal disease; however, cases of preeclampsia and preterm birth have been infrequently reported. Reports of placental infection and vertical transmission are rare. Interestingly, despite lack of SARS-CoV-2 placenta infection, there are several reports of significant abnormalities in placenta morphology. Continued research on pregnant women infected with SARS-CoV-2 and their offspring is vitally important.

scholarly journals Provision of intensive care to severely ill pregnant women is associated with reduced mortality: Results from the WHO Multicountry Survey on Maternal and Newborn Health

2020 ◽  
Vol 150 (3) ◽  
pp. 346-353
Author(s):  
Fabiano M. Soares ◽  
Rodolfo C. Pacagnella ◽  
Özge Tunçalp ◽  
José G. Cecatti ◽  
Joshua P. Vogel ◽  
...  
Keyword(s):  
Intensive Care ◽  
Pregnant Women ◽  
Newborn Health ◽  
Maternal And Newborn Health ◽  
Maternal And Newborn

scholarly journals Rates and risk factors for preterm birth and low birthweight in the global network sites in six low- and low middle-income countries

2020 ◽  
Vol 17 (S3) ◽  
Author(s):  
Yamini V. Pusdekar ◽  
Archana B. Patel ◽  
Kunal G. Kurhe ◽  
Savita R. Bhargav ◽  
Vanessa Thorsten ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Preterm Birth ◽  
Newborn Health ◽  
Maternal And Newborn Health ◽  
Middle Income ◽  
Factors Associated ◽  
Middle Income Countries ◽  
Health Registry ◽  
Maternal And Newborn

Abstract Background Preterm birth continues to be a major public health problem contributing to 75% of the neonatal mortality worldwide. Low birth weight (LBW) is an important but imperfect surrogate for prematurity when accurate assessment of gestational age is not possible. While there is overlap between preterm birth and LBW newborns, those that are both premature and LBW are at the highest risk of adverse neonatal outcomes. Understanding the epidemiology of preterm birth and LBW is important for prevention and improved care for at risk newborns, but in many countries, data are sparse and incomplete. Methods We conducted data analyses using the Global Network’s (GN) population-based registry of pregnant women and their babies in rural communities in six low- and middle-income countries (Democratic Republic of Congo, Kenya, Zambia, Guatemala, India and Pakistan). We analyzed data from January 2014 to December 2018. Trained study staff enrolled all pregnant women in the study catchment area as early as possible during pregnancy and conducted follow-up visits shortly after delivery and at 42 days after delivery. We analyzed the rates of preterm birth, LBW and the combination of preterm birth and LBW and studied risk factors associated with these outcomes across the GN sites. Results A total of 272,192 live births were included in the analysis. The overall preterm birth rate was 12.6% (ranging from 8.6% in Belagavi, India to 21.8% in the Pakistani site). The overall LBW rate was 13.6% (ranging from 2.7% in the Kenyan site to 21.4% in the Pakistani site). The overall rate of both preterm birth and LBW was 5.5% (ranging from 1.2% in the Kenyan site to 11.0% in the Pakistani site). Risk factors associated with preterm birth, LBW and the combination were similar across sites and included nulliparity [RR − 1.27 (95% CI 1.21–1.33)], maternal age under 20 [RR 1.41 (95% CI 1.32–1.49)] years, severe antenatal hemorrhage [RR 5.18 95% CI 4.44–6.04)], hypertensive disorders [RR 2.74 (95% CI − 1.21–1.33], and 1–3 antenatal visits versus four or more [RR 1.68 (95% CI 1.55–1.83)]. Conclusions Preterm birth, LBW and their combination continue to be common public health problems at some of the GN sites, particularly among young, nulliparous women who have received limited antenatal care services. Trial registration The identifier of the Maternal and Newborn Health Registry at ClinicalTrials.gov is NCT01073475.Trial registration: The identifier of the Maternal and Newborn Health Registry at ClinicalTrials.gov is NCT01073475.

scholarly journals Setting up a maternal and newborn health programme

2019 ◽  
pp. 294-312
Author(s):  
Ted Lankester
Keyword(s):  
Pregnant Women ◽  
Postnatal Care ◽  
Causes Of Death ◽  
Newborn Health ◽  
Traditional Birth Attendants ◽  
Maternal And Newborn Health ◽  
Remote Areas ◽  
Birth Attendants ◽  
Health Programme ◽  
Maternal And Newborn

This chapter discusses causes of death and disability from preventable causes in both mothers and newborns. It outlines what can be done to maximize the health of pregnant women, mothers, and newborns through preparing the community, encouraging birth plans, and setting up antenatal, neonatal, and postnatal care. It describes the ongoing value of traditional birth attendants (TBAs) and midwives in remote areas when carefully trained, while emphasizing the need for facility-based delivery when available and the need to ensure that patients are treated with dignity and understanding. As in other chapters, it summarizes ways to keep records and evaluate the programme.

scholarly journals Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman

2020 ◽  
Author(s):  
Sam Schoenmakers ◽  
Pauline Snijder ◽  
Robert M Verdijk ◽  
Thijs Kuiken ◽  
Sylvia S M Kamphuis ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Vertical Transmission ◽  
Neonatal Intensive Care ◽  
Quantitative Polymerase Chain Reaction ◽  
Antigen Expression ◽  
Fetal Distress ◽  
Adverse Outcomes ◽  
Placental Infection ◽  
Emergency Cesarean ◽  
Increased Risk

Abstract Background In general, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy is not considered to be an increased risk for severe maternal outcomes but has been associated with an increased risk for fetal distress. Maternal-fetal transmission of SARS-CoV-2 was initially deemed uncertain; however, recently a few cases of vertical transmission have been reported. The intrauterine mechanisms, besides direct vertical transmission, leading to the perinatal adverse outcomes are not well understood. Methods Multiple maternal, placental, and neonatal swabs were collected for the detection of SARS-CoV-2 using real-time quantitative polymerase chain reaction (RT-qPCR). Serology of immunoglobulins against SARS-CoV-2 was tested in maternal, umbilical cord, and neonatal blood. Placental examination included immunohistochemical investigation against SARS-CoV-2 antigen expression, with SARS-CoV-2 ribonucleic acid (RNA) in situ hybridization and transmission electron microscopy. Results RT-qPCRs of the oropharynx, maternal blood, vagina, placenta, and urine were all positive over a period of 6 days, while breast milk, feces, and all neonatal samples tested negative. Placental findings showed the presence of SARS-CoV-2 particles with generalized inflammation characterized by histiocytic intervillositis with diffuse perivillous fibrin depositions with damage to the syncytiotrophoblasts. Conclusions Placental infection by SARS-CoV-2 leads to fibrin depositions hampering fetal-maternal gas exchange with resulting fetal distress necessitating a premature emergency cesarean section. Postpartum, the neonate showed a fetal or pediatric inflammatory multisystem-like syndrome with coronary artery ectasia temporarily associated with SARS-CoV-2 for which admittance and care on the neonatal intensive care unit (NICU) were required, despite being negative for SARS-CoV-2. This highlights the need for awareness of adverse fetal and neonatal outcomes during the current coronavirus disease 2019 pandemic, especially considering that the majority of pregnant women appear asymptomatic.

scholarly journals Maternal and newborn health risks of climate change: A call for awareness and global action

2021 ◽  
Author(s):  
Nathalie Roos ◽  
Sari Kovats ◽  
Shakoor Hajat ◽  
Veronique Filippi ◽  
Matthew Chersich ◽  
...  
Keyword(s):  
Climate Change ◽  
Health Risks ◽  
Newborn Health ◽  
Maternal And Newborn Health ◽  
Global Action ◽  
Maternal And Newborn
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