Rate of bone loss in postmenopausal and osteoporotic women

1982 ◽  
Vol 242 (2) ◽  
pp. E82-E86 ◽  
Author(s):  
J. F. Aloia ◽  
P. Ross ◽  
A. Vaswani ◽  
I. Zanzi ◽  
S. H. Cohn
Keyword(s):  
Bone Mass ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Rate Of Change ◽  
Total Body Calcium ◽  
Total Skeleton ◽  
Group A ◽  
Bone Mineral Measurements ◽  
Total Body ◽  
Group B

Regional and total bone mass were determined in three groups of women by photon absorptiometry of the distal radius [bone mineral content BMC)] and total body neutron activation analysis [total body calcium (TBCa)], respectively. There were three groups of patients: group A, osteoporotic women treated with a variety of pharmacologic agents; group B, osteoporotic women (controls) taking only calcium supplements; and group C, normal postmenopausal women. The mean TBCa and BMC were considerably higher in the postmenopausal women than in the osteoporotic women. The rate of change of bone mass in group C was -0.45%/yr and -0.9%/yr for the total skeleton and radius, respectively. Group B had no significant rate of loss, whereas group A demonstrated a significant increase in TBCa of 0.75%/yr with no change in the BMC of the radius. There were no significant between-subject correlations for the slopes (rates of change) of the two bone mineral measurements.

Skeletal mass in postmenopausal women.

1978 ◽  
Vol 235 (1) ◽  
pp. E82
Author(s):  
J F Aloia ◽  
S H Cohn ◽  
P Ross ◽  
A Vaswani ◽  
C Abesamis ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Mineral Content ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Content ◽  
Total Body Calcium ◽  
Skeletal Mass ◽  
Normal Women ◽  
Total Body

The techniques of photon absorptiometry of the radius and total body neutron activation analysis were used for the determination of bone mineral content and total body calcium, respectively. The subjects consisted of 71 normal women who were 1-5 yr postmenopausal and 44 osteoporotic women who had crush fractures of the dorsal spine. Both bone mineral content and total body calcium were corrected for age and body size by using the ratio of observed values to those predicted from previously derived equations. Discrimant analysis involving both osteoporotic and normal postmenopausal women resulted in the successful assignment of 81% of the 115 subjects to their correct group. Statistical analyses of the distribution of the bone mass of the postmenopausal women yielded no evidence to support the hypothesis that a subgroup exists with bone mass levels markedly different from the remainder of the women.

scholarly journals A Study of the Relationship between the Polymorphism and Mutation of rs682429 and rs3781590 in the LRP5 Gene and Bone Metabolism in Postmenopausal Type 2 Diabetic Women in Xinjiang

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Jun Li ◽  
SiYuan Li ◽  
HuiRong Zhao ◽  
JiaJia Li ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
X Ray ◽  
Group A ◽  
Mass Group ◽  
Group B ◽  
The Relationship ◽  
Group D

Objective. To explore the expression of the polymorphism and mutation of rs682429 and rs3781590 in the low-density lipoprotein receptor-related protein 5 (LRP5) genotype and to analyse the relationship of bone mineral density (BMD) and bone metabolism markers in postmenopausal women with type-2 diabetes mellitus (T2DM) in Xinjiang, China, to provide a basis for prevention and treatment of the disease. Methods. A total of 136 postmenopausal women were included in the study. According to the results of an oral glucose tolerance test (OGTT) and dual-energy X-ray (DEXA) determination of BMD, the study subjects were divided into 4 groups: group A: normal OGTT+normal bone mass group; group B: normal OGTT+osteoporotic (OP) group; group C: T2DM+normal bone mass group; group D: T2DM+osteoporotic (OP) group. Calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), and clinical biochemical data were determined; haemoglobin A1c (HbA1c) was measured by HPLC; BMD of the femoral neck, hip, and lumbar spine (L1-4) was measured by dual-energy X-ray (DEXA); and the rs682429 and rs3781590 polymorphisms of the LRP5 gene were detected by time-of-flight mass spectrometry (TOF MS). Results. (1) The rs682429 polymorphism of the LRP5 genotype distribution was statistically significant (P<0.05) in group B compared with group A. (2) The triglycerides (TG) of women with the CT/TT genotype (mutant type) were higher than those of women with the CC genotype (wild type) (2.37±1.30 vs. 1.52±0.83, P<0.05) at the rs3781590 site of the LRP5 gene in group D. (3) Multiple linear regression analysis showed that TG (β=0.034, P<0.05) and body mass index (BMI) (β=0.013, P<0.05) were the influencing factors of BMD (L1-4) in T2DM patients. TG (β=0.022, P<0.05), BMI (β=0.009, P<0.05), and duration of menopause (β=0.005, P<0.05) were the influencing factors of BMD (hip). Conclusion. (1) The rs682429 polymorphism site in the LRP5 gene may be involved in bone metabolism in postmenopausal women from Xinjiang. (2) The rs3781590 mutation in the LRP5 gene from these subjects may be involved in lipid metabolism. (3) Among postmenopausal women with type 2 diabetes mellitus and bone mass abnormality in the Xinjiang Shihezi area, high BMI and TG are protective factors against increased BMD. Duration of menopause is a risk factor for increased BMD.

Effects of chronic heroin abuse on bone and mineral metabolism

1993 ◽  
Vol 129 (1) ◽  
pp. 42-45 ◽  
Author(s):  
Mario Pedrazzoni ◽  
Pier P Vescovi ◽  
Letizia Maninetti ◽  
Massimo Michelini ◽  
Giulio Zaniboni ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Drug Discontinuation ◽  
Dual Photon Absorptiometry ◽  
Control Subjects ◽  
Opiate Abuse ◽  
Opioid Drugs ◽  
Group A ◽  
Group B

Though the chronic use of opiates can modify several body functions, only a few data are available on the effects of opioid drugs on mineral metabolism. We have examined the possible consequences of chronic opiate abuse on bone mass, bone turnover and calcium metabolism in 13 male chronic heroin users, examined 1–2 days after the last administration of the drug (group A), 14 former male heroin addicts, examined 4–24 months after drug discontinuation (group B), and 22 healthy, age- and sex-matched control subjects. In group A, the vertebral bone mineral density (measured by Dual-Photon Absorptiometry) was significantly lower (p <0.05) than in the control subjects, despite similar values of total body bone mineral, lean body and fat mass. Blood-ionised calcium and urinary calcium and hydroxyproline were significantly increased (p<0.01), whereas parathyroid hormone was lower than in controls (p<0.01). Bone alkaline phosphatase and osteocalcin, however, were not significantly different from the control values. LH and testosterone levels were low (p <0.01 vs controls). In contrast, group B subjects did not show significant differences from the control group. The chronic abuse of opioid drugs may be associated with altered bone metabolism and reduced trabecular bone mass, attributable, at least in part, to gonadal deficiency. These alterations seem reversible after drug discontinuation.

scholarly journals Bone Turnover Markers Relations to Postmenopausal Osteoporosis

2009 ◽  
Vol 28 (3) ◽  
pp. 161-165 ◽  
Author(s):  
Jasmina Jovčevska ◽  
Slavica Stratrova ◽  
Icko Gjorgovski ◽  
Todor Gruev ◽  
Mimoza Kotevska ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Mass ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
High Bone ◽  
Group A ◽  
Turnover Markers ◽  
Group B

Bone Turnover Markers Relations to Postmenopausal OsteoporosisOsteoporosis is a systemic disease characterized by low bone mass and high bone turnover markers in postmenopausal women (PM). The relationship between biochemical bone markers C-telopeptides of type 1 collagen (CTX) and osteocalcin (OC), and bone mineral density (BMD) in the postmenopausal period was examined in 104 PM women divided into three groups according to their BMD: group A - control PM with normal bone density, group B - osteopenic PM and group C - osteoporotic PM. Mean CTX values were highest in group C (0.54±0.24 ng/mL) compared to group B (0.44±0.21 ng/mL) (p<0.0001), and group A (0.33±0.13 ng/mL) (p<0.029). Mean OC levels in group C (26.83±9.91 ng/mL) were significantly higher compared to group A (20.47±7.03 ng/mL) (p<0.011) but not significantly higher compared to group B (24.11±8.38 ng/mL) (p>0.05). Postmenopause duration was longest in group C (13.1±8.31 yrs) compared to group B (9.6±6.24 yrs), and group A (8.15±6.86 yrs). Postmenopausal women developed osteoporosis with longer menopause duration. PM osteoporotic women were characterized by increased levels of bone turnover markers indicating increased rate of bone remodeling, which resulted in excessive bone resorption, and loss of bone mass. Long-term persistence of high bone resorption marker CTX, insufficiently compensated with bone formation marker OC, enabled osteoporosis development.

Oral alendronate induces progressive increases in bone mass of the spine, hip, and total body over 3 years in postmenopausal women with osteoporosis

Bone ◽  
1996 ◽  
Vol 18 (2) ◽  
pp. 141-150 ◽  
Author(s):  
J.P. Devogelaer ◽  
H. Broll ◽  
R. Correa-Rotter ◽  
D.C. Cumming ◽  
C. Nagant de Deuxchaisnes ◽  
...  
Keyword(s):  
Bone Mass ◽  
Postmenopausal Women ◽  
Total Body

scholarly journals Effect of dietary concentrate level on body immune response in calves fed a wheat straw-based diet : short communication

2000 ◽  
Vol 71 (4) ◽  
Author(s):  
A. Santra ◽  
N.N. Pathak
Keyword(s):  
Immune Response ◽  
Wheat Straw ◽  
Body Weight Gain ◽  
Total Body Weight ◽  
Differential Leukocyte Count ◽  
Concentrate Supplementation ◽  
Group A ◽  
Group Protein ◽  
Total Body ◽  
Group B

Twenty 9-month-old crossbred calves were divided into 2 equal groups (A and B; n = 10). The feeding trial was conducted for 119 days to study the effect of concentrate supplementation on body immune response and blood metabolites in calves. The concentrate and roughage (wheat straw) ratio in the diet of Groups A and B was 60:40 and 30:70, respectively. Daily dry matter intake was significantly (P < 0.01) higher in Group A than in Group B, which also resulted in significantly higher (P < 0.01) total body weight gain in the former group. Protein, albumin, globulin, total and differential leukocyte count in blood were similar in the 2 groups but blood glucose level was higher (P < 0.05) in the calves of Group A. There was no difference in body immune response between the groups, which indicated that body immune response of animals is not significantly influenced by restricted concentrate feeding.

Fragility Vertebral Compression Fractures in Postmenopausal Women: The Role of a Fracture Liaison Service Program

2020 ◽  
pp. 000313482093325
Author(s):  
Avery Jackson ◽  
Tarik Wasfie ◽  
Caramarie Brock ◽  
Stefanija Galovska ◽  
Melany Smalley ◽  
...  
Keyword(s):  
Vitamin D ◽  
Postmenopausal Women ◽  
Fragility Fractures ◽  
Fracture Liaison Service ◽  
Vertebral Compression Fractures ◽  
Compression Fractures ◽  
Vitamin D Levels ◽  
Group A ◽  
Group B ◽  
Fracture Liaison

Background As the aging population increases in the United States, so has the prevalence of osteoporosis (10.2 million adults aged 50 years and older in 2010). Programs to manage the increased incidence of fragility fractures in such patients particularly the postmenopausal women are the priority. Programs such as the Fracture Liaison Service (FLS) might be the answer. Methods Data of 256 postmenopausal women with vertebral compression fractures treated with vertebroplasty between 2012 and 2017 were divided into 2 groups. Group A were patients seen between 2012 and 2014 before the establishment of the FLS program at the clinic. Group B were patients seen between 2015 and 2017 who presented to the FLS program in our clinic. Data collected included demographics, refracture rates, dual-energy X-ray absorptiometry (DEXA) scan T-scores, fracture risk score (FRAX), serum calcium and vitamin D levels, and comorbid conditions. Results There were 103 female patients with a mean age of 79.75 years (standard deviation [SD] ± 10.86) in group A, while group B had 153 patients with a mean age of 75.66 years (SD ± 10.78). There was no significant difference in the DEXA scan T-scores, FRAX scores, and mean serum calcium and vitamin D levels; however, there was a significant reduction in the refracture rate for vertebral compression fractures ( P = .003). Conclusion FLS programs, when implemented, will have a beneficial effect in reducing refracture rates of postmenopausal women with osteoporotic fragility fractures.

Serum Osteocalcin and Total Body Calcium in Normal Pre- and Postmenopausal Women and Postmenopausal Osteoporotic Patients*

1987 ◽  
Vol 64 (4) ◽  
pp. 681-685 ◽  
Author(s):  
SEIICHI YASUMURA ◽  
JOHN F. ALOIA ◽  
CAREN M. GUNDBERG ◽  
JAMES YEH ◽  
ASHOK N. VASWANI ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Serum Osteocalcin ◽  
Total Body Calcium ◽  
Total Body

scholarly journals Adiposity, Insulin Resistance, and Bone Mass in Children and Adolescents

2018 ◽  
Vol 104 (3) ◽  
pp. 892-899 ◽  
Author(s):  
Joseph M Kindler ◽  
Andrea J Lobene ◽  
Kara A Vogel ◽  
Berdine R Martin ◽  
Linda D McCabe ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Insulin Resistance ◽  
Waist Circumference ◽  
Bone Mass ◽  
Bone Mineral ◽  
Fat Mass ◽  
Areal Bone Mineral Density ◽  
Mineral Density ◽  
Total Body ◽  
The Relationship

Abstract Context Insulin resistance is an adverse health outcome that accompanies obesity. Fat mass is negatively associated with the bone mass after adjustment for confounders. Insulin resistance might be an intermediary in this relationship. Objective To determine whether insulin resistance is an intermediary in the relationship between adiposity and bone mass in adolescents. Design Cross-sectional secondary analysis of baseline data from a previous randomized trial. Setting University research facility. Participants A total of 240 adolescents (68% female), aged 7 to 15 years. Main Outcome Measures Using dual energy x-ray absorptiometry, bone mineral content (BMC), areal bone mineral density, lean mass, and fat mass were measured. Skeletal sites of interest included the total body and lumbar spine (LS). Waist circumference was measured using an anthropometric tape measure. Insulin and glucose were measured in fasting sera, and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Path analysis was performed to determine whether the relationship between adiposity and bone was mediated through insulin resistance. Results Fat mass (r = 0.467; P &lt; 0.001) and waist circumference (r = 0.487; P &lt; 0.001) correlated positively with HOMA-IR. Controlling for race, sex, maturation, lean mass, and height, fat mass, waist circumference, and HOMA-IR were negatively associated with LS BMC and total body areal bone mineral density (P &lt; 0.05 for all). Additionally, path models for fat mass (95% CI, −5.893 to −0.956) and waist circumference (95% CI, −15.473 to −2.124) showed a negative relationship with LS BMC via HOMA-IR. Conclusions These results support an intermediary role of insulin resistance in the relationship between adiposity and LS bone mass.

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