Blood pressure changes PVAT function and transcriptome: use of the mid-thoracic aorta coarcted rat
2020 ◽
Vol 319
(6)
◽
pp. H1313-H1324
Keyword(s):
A mid-thoracic aorta coarcted rat was created to generate a stable pressure difference above versus below the coarctation ligature. This study determined that the PVAT around the thoracic aorta exposed to a higher pressure has a significantly reduced ability to assist stress relaxation versus that below the ligature and appears to retain the ability to be anticontractile. At the same time, the PVAT around the thoracic aorta exposed to higher pressure had a reduced adipogenic potential versus that below the ligature. Transcriptomics analyses indicated that PVAT below the coarctation showed the greatest number of DEGs with an increased profile of the synaptic neurotransmitter gene network.
2020 ◽
Vol 4
(11)
◽
Keyword(s):
Keyword(s):
1985 ◽
Vol 19
(4)
◽
pp. 524-526
2016 ◽
Vol 34
(Supplement 1)
◽
pp. e121
1997 ◽
Vol 32
(3)
◽
pp. 272-287
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