Role of t-tubule remodeling on mechanisms of abnormal calcium release during heart failure development in canine ventricle
2021 ◽
Vol 320
(4)
◽
pp. H1658-H1669
Keyword(s):
Three-dimensional analysis of t-tubule density showed t-tubule disruption throughout the whole myocyte in failing dog ventricle. A double-linear relationship between Ca2+ release and t-tubule density displays a steeper slope at t-tubule densities below a threshold value (∼1.5%) above which there is little effect on Ca2+ release (T-tubule reserve). T-tubule loss increases incidence of triggered Ca2+ waves. Chemically induced t-tubule disruption suggests that t-tubule loss alone is a critical component of abnormal Ca2+ cycling in heart failure.
2008 ◽
Vol 25
(9)
◽
pp. 983-992
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2016 ◽
Vol 121
(14)
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pp. 8429-8443
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2015 ◽
Vol 645-646
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pp. 968-971
2019 ◽
Vol 5
(3)
◽
pp. 1518-1533
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1992 ◽
Vol 436
(1897)
◽
pp. 405-415
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Keyword(s):
1978 ◽
Vol 36
(1)
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pp. 634-635