Effect of exercise on uterine blood flow in the pregnant Pygmy goat

1984 ◽  
Vol 246 (2) ◽  
pp. H207-H212 ◽  
Author(s):  
A. R. Hohimer ◽  
J. M. Bissonnette ◽  
J. Metcalfe ◽  
T. A. McKean
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Artery Blood Flow ◽  
Normal Birth Weight ◽  
Uterine Blood Flow ◽  
Normal Birth ◽  
Radioactive Microsphere ◽  
Radioactive Microsphere Technique ◽  
Placental Blood ◽  
Placental Blood Flow

Pygmy goats in the last third of pregnancy were trained to walk on a treadmill at rates up to 2.0 mph and up an inclination of 0-15 degrees. Electromagnetic flowmeters were placed unilaterally on a uterine artery, and measurements were made while the goats were standing quietly on the treadmill and during 5 min of exercise. Blood flow fell during exercise in all five animals studied, and this reduction was proportional to the level of exertion. At the highest level of exercise that these animals would voluntarily perform, uterine artery blood flow fell by 32 +/- 3 (SE) % (P less than 0.001) from control. In four additional animals the radioactive microsphere technique was used to measure uterine blood flow at rest and after 5-7 min of exercise. In these animals, exercise caused total uterine blood flow to fall by 18 +/- 10%; cotyledonary (placental) blood flow fell by 8 +/- 13%, while myoendometrial blood flow decreased by 52 +/- 12% (P less than 0.05). Thus nonplacental portions of the pregnant Pygmy goat uterus suffer major reductions in blood flow during exercise. This vasoconstriction may be due to exercise per se or to concomitant hypocapnia or hyperthermia. Singleton and twin kids born to animals that exercised were of normal birth weight.

Association of placental T2 relaxation times and uterine artery Doppler ultrasound measures of placental blood flow

Placenta ◽  
2013 ◽  
Vol 34 (6) ◽  
pp. 474-479 ◽  
Author(s):  
I. Derwig ◽  
G.J. Barker ◽  
L. Poon ◽  
F. Zelaya ◽  
P. Gowland ◽  
...  
Keyword(s):  
Blood Flow ◽  
Doppler Ultrasound ◽  
Uterine Artery ◽  
Relaxation Times ◽  
T2 Relaxation ◽  
Uterine Artery Doppler ◽  
Placental Blood ◽  
Placental Blood Flow

scholarly journals Maternal Blood Concentration of Tadalafil and Uterine Blood Flow in Pregnancy

Medicina ◽  
2019 ◽  
Vol 55 (10) ◽  
pp. 708
Author(s):  
Tanaka ◽  
Maki ◽  
Magawa ◽  
Nii ◽  
Tanaka ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pregnant Women ◽  
Blood Concentration ◽  
Uterine Artery ◽  
Maternal Blood ◽  
Artery Blood Flow ◽  
Uterine Blood Flow ◽  
Once Daily ◽  
Kinetics Of ◽  
The Ideal

: Background and Objectives: Tadalafil for treatment of fetal growth restriction (FGR) or preeclampsia is given once a day orally. The drug kinetics of tadalafil were investigated to determine the ideal dosage to promote uterine blood flow. Materials and Methods: We recruited five pregnant women with FGR or preeclampsia before administration of tadalafil, all of which were administered tadalafil (20 mg/day, once-daily dosing). The blood concentration of tadalafil was measured 1, 2, 4, 6, 8, and 24 h after administration, and uterine blood flow was measured before tadalafil administration and 2–4 and 20–24 h after. We then analyzed the correlation between tadalafil blood concentration and uterine artery blood flow. Results: The blood concentration of tadalafil correlated with uterine artery blood flow in pregnant women. The blood concentration of tadalafil and uterine artery blood flow decreased 5 h after administration of tadalafil. Conclusions: The blood concentration of tadalafil and uterine artery blood flow fluctuate in parallel, the latter was decreased by reduced blood concentration. Thus, a study of tadalafil administered twice a day in pregnant women will be needed to stabilize uterine artery blood flow.

Chronic alterations in ovine maternal corticosteroid levels influence uterine blood flow and placental and fetal growth

2005 ◽  
Vol 288 (1) ◽  
pp. R54-R61 ◽  
Author(s):  
Ellen Jensen ◽  
Charles E. Wood ◽  
Maureen Keller-Wood
Keyword(s):  
Blood Flow ◽  
Plasma Cortisol ◽  
Somatic Growth ◽  
Maternal Plasma ◽  
Control Group ◽  
Uterine Blood Flow ◽  
Arterial Blood ◽  
Placental Blood ◽  
Low Cortisol ◽  
Placental Blood Flow

Previous work from this laboratory demonstrated that the elevation of maternal plasma corticosteroid concentrations during pregnancy is important for the support of fetal development. Reducing ovine maternal plasma cortisol concentrations to nonpregnant levels stimulates homeostatic responses that defend fetal blood volume. The present study was designed to test the hypothesis that chronic decreases or increases in maternal plasma cortisol concentration alter uterine and placental blood flow and morphology. Three groups of pregnant ewes and their fetuses were chronically catheterized and studied: ewes infused with cortisol (1 mg·kg−1·day−1; high cortisol), ewes adrenalectomized and underreplaced with cortisol (0.5 mg·kg−1·day−1; low cortisol), and control ewes. The normal increment in uterine blood flow between 120 and 130 days was eliminated in the low-cortisol ewes; conversely, uterine blood flow was increased in the high-cortisol group compared with the control group. Fetal arterial blood pressure was increased in the high-cortisol group compared with controls, but there was no increase in fetal arterial pressure from 120 to 130 days of gestation in the low-cortisol group. The fetuses of both low-cortisol and high-cortisol groups had altered placental morphology, with increased proportions of type B placentomes, and overall reduced fetal placental blood flow. The rate of fetal somatic growth was impaired in both low-cortisol and high-cortisol groups compared with the fetuses in the intact group. The results of this study demonstrate that maternal plasma cortisol during pregnancy is an important contributor to the maternal environment supporting optimal conditions for fetal homeostasis and somatic growth.

The role of thromboxane in the uterotrophic response in the gravid normotensive and spontaneously hypertensive rat

1992 ◽  
Vol 135 (2) ◽  
pp. 257-261 ◽  
Author(s):  
M. B. Kerr ◽  
K. Marshall ◽  
J. Senior
Keyword(s):  
Blood Flow ◽  
Spontaneously Hypertensive Rat ◽  
Clinical Indication ◽  
Uterine Blood Flow ◽  
Spontaneously Hypertensive ◽  
Uteroplacental Blood Flow ◽  
Placental Blood ◽  
Prophylactic Use ◽  
Placental Blood Flow

ABSTRACT The role of thromboxane in the gravid normotensive (CD) and hypertensive (SHR) rat was investigated (by utilizing two thromboxane receptor-blocking drugs, EP092 and AH23848) both at mid-gestation and at term. The parameters examined were uterine blood flow (blood flows were measured by the microsphere technique) and uterine weight and placental blood flow at term, fetal mass and number. At mid-gestation EP092 significantly (P< 0·005) increased uterine blood flow in both strains whilst the increases seen with AH23848 were not statistically significant. At term (day 22 in the CD and day 23 in the SHR rat) the antagonists increased uterine blood flow in the CD rats alone. However, at this time the antagonists caused an increase in placental blood flow in both strains. Thromboxane appears to be involved in the regulation of uteroplacental blood flow. The observation that the antagonists were able to potentiate blood flow by mid-gestation may provide a clinical indication with respect to potential prophylactic use of this class of compounds in cases of pregnancy-induced hypertension in women. Journal of Endocrinology (1992) 135, 257–261

Effects of intravenous infusions of noradrenaline into the pregnant ewe on uterine blood flow, fetal renal function, and lung liquid flow

1995 ◽  
Vol 73 (2) ◽  
pp. 202-208 ◽  
Author(s):  
A. D. Stevens ◽  
E. R. Lumbers
Keyword(s):  
Blood Flow ◽  
Arterial Pressure ◽  
Liquid Flow ◽  
Urine Flow ◽  
Uterine Blood Flow ◽  
Water Excretion ◽  
Fetal Urine ◽  
Placental Blood ◽  
Lung Liquid ◽  
Placental Blood Flow

To determine the effects on the fetus of high maternal levels of noradrenaline, experiments were carried out in 17 pregnant ewes (123–137 days gestation). Intravenous infusion of 40 mg/min of norepinephrine to the ewe for 1.5 h increased maternal arterial pressure and significantly decreased maternal placental blood flow (p < 0.05). Fetal arterial pressure did not change, but fetal arterial [Formula: see text] fell (p < 0.01) and [Formula: see text] rose (p < 0.01). Fetal urine flow fell and osmolality rose (p < 0.01), fetal lung liquid flow and osmolar excretion fell (p < 0.01, p < 0.05, respectively), and the lung sodium:potassium ratio changed. These effects of high levels of maternal noradrenaline were transient, i.e., 2.5 h after the infusion of noradrenaline had finished, fetal urine flow and lung liquid flow had both returned to control values and fetal [Formula: see text] was significantly depressed relative to control values (p < 0.01). It is concluded that high levels of maternal catecholamines reduce placental blood flow and cause small changes in fetal oxygenation. These changes are sufficient to transiently affect fetal water excretion and to reduce lung liquid flow.Key words: maternal noradrenaline, uterine blood flow, fetal oxygen, lung liquid, blood volume, fetal, renal.

scholarly journals USING RESULTS OF FIRST-TRIMESTER BIOCHEMICAL SCREENING AND UTERINE ARTERY PULSATILITY INDEX FOR INCLUSION IN RISK GROUPS FOR FETAL GROWTH RESTRICTION

2017 ◽  
pp. 52-56
Author(s):  
R. S. Zamaleeva ◽  
N. A. Cherepanova ◽  
D. V. Frizin ◽  
A. V. Frizina
Keyword(s):  
Blood Flow ◽  
Fetal Growth ◽  
Uterine Artery ◽  
Risk Group ◽  
Risk Groups ◽  
First Trimester ◽  
Maternity Unit ◽  
Biochemical Screening ◽  
Placental Blood ◽  
Placental Blood Flow

Objective: to study the combined use of first-trimester biochemical screening results and uterine artery pulsality index (PI) for inclusion in risk group for fetal growth restriction (FGR), improvement of pregnancy outcomes in women from the risk group for the development of FGR.Material and methods. The work is based on the results of studies conducted from 2009 to 2014 in the maternity unit of Republican Clinical Hospital № 2 MoH in the Republic of Tatarstan which is the clinical facility for the Department of Obstetrics and Gynecology № 1 of the Continuing Medical Education Institution “Kazan State Medical University” MoH RF, and maternity unit and prenatal clinic of the Volzhskaya Central City Hospital in the Mari El Republic. First-trimester biochemical screening results and uterine artery PI were the basis for the formation of FGR risk groups. Pregnancy and delivery outcomes in 156 pregnant women with a risk for the development of FGR and in 25 healthy controls were evaluated. In order to improve the placental blood flow based on the proven safety profile, all women with FGR received dipyridamole in the II trimester of pregnancy for at least 3 weeks.Conclusion: concomitant decrease in PAPP-A MoM and increase in uterine artery PI provide the most valuable information for forecasting FGR. Administration of dipyridamole by women with FGR helps to improve placental blood flow, prevents degenerative changes in the placenta, and promotes live births even in III degree FGR. 

Placental Blood Flow and Fetal Weight following Uterine Artery Ligation

Neonatology ◽  
1986 ◽  
Vol 49 (3) ◽  
pp. 172-180 ◽  
Author(s):  
Thomas Jansson ◽  
Magnus Thordstein ◽  
Ingemar Kjellmer
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Fetal Weight ◽  
Artery Ligation ◽  
Uterine Artery Ligation ◽  
Placental Blood ◽  
Placental Blood Flow
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