Volumetric response of right ventricle during progressive supine exercise in men

Right ventricular (RV) adaptation to supine exercise has been studied in 10 young male volunteers by 81mKr electrocardiogram (ECG)-gated radionuclide ventriculography. During progressive supine exercise, the ejection fraction gradually increased from a mean value of 46% at rest up to 60% at a maximal exercise level. End-diastolic volume however remained unchanged at a low exercise level and even slightly decreased at a higher exercise level. Little or no change in end-diastolic volume and an increase in ejection fraction produced a significant decrease in end-systolic volume and a net increase in stroke volume. These results indicate that the Frank-Starling mechanism does not contribute to the increase in right ventricular stroke volume during progressive supine exercise, but the increase in right ventricular stroke volume rather seems related to an increased contractility, presumably mediated by an increased sympathetic activity.

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Effect of the mechanical ventilatory cycle on thermodilution right ventricular volumes and cardiac output

Journal of Applied Physiology ◽

10.1152/jappl.2000.89.1.89 ◽

2000 ◽

Vol 89 (1) ◽

pp. 89-96 ◽

Cited By ~ 42

Author(s):

A. B. Johan Groeneveld ◽

Remco R. Berendsen ◽

Anton J. Schneider ◽

Ioannis A. Pneumatikos ◽

Leo A. Stokkel ◽

...

Keyword(s):

Mechanical Ventilation ◽

Cardiac Output ◽

Ejection Fraction ◽

Right Ventricular ◽

Mean Value ◽

Mean Values ◽

Systolic Volume ◽

End Diastolic Volume ◽

Reliable Assessment ◽

End Systolic Volume

The purpose of this study was to evaluate right ventricular (RV) loading and cardiac output changes, by using the thermodilution technique, during the mechanical ventilatory cycle. Fifteen critically ill patients on mechanical ventilation, with 5 cmH2O of positive end-expiratory pressure, mean respiratory frequency of 18 breaths/min, and mean tidal volume of 708 ml, were studied with help of a rapid-response thermistor RV ejection fraction pulmonary artery catheter, allowing 5-ml room-temperature 5% isotonic dextrose thermodilution measurements of cardiac index (CI), stroke volume (SV) index, RV ejection fraction (RVEF), RV end-diastolic volume (RVEDV), and RV end-systolic volume (RVESV) indexes at 10% intervals of the mechanical ventilatory cycle. The ventilatory modulation of CI and RV volumes varied from patient to patient, and the interindividual variability was greater for the latter variables. Within patients also, RV volumes were modulated more by the ventilatory cycle than CI and SV index. Around a mean value of 3.95 ± 1.18 l · min−1 · m−2 (= 100%), CI varied from 87.3 ± 5.2 (minimum) to 114.3 ± 5.1% (maximum), and RVESV index varied between 61.5 ± 17.8 and 149.3 ± 34.1% of mean 55.1 ± 17.9 ml/m2 during the ventilatory cycle. The variations in the cycle exceeded the measurement error even though the latter was greater for RVEF and volumes than for CI and SV index. For mean values, there was an inspiratory decrease in RVEF and increase in RVESV, whereas a rise in RVEDV largely prevented a fall in SV index. We conclude that cyclic RV afterloading necessitates multiple thermodilution measurements equally spaced in the ventilatory cycle for reliable assessment of RV performance during mechanical ventilation of patients.

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Cross-sectional echocardiographic determination of right ventricular volume and myocardial mass in children. Normal values and values in children with interatrial communication

Cardiology in the Young ◽

10.1017/s1047951100004194 ◽

1997 ◽

Vol 7 (3) ◽

pp. 302-309 ◽

Cited By ~ 2

Author(s):

Zhen Jin ◽

Walter Briedigkeit ◽

Andreas Gamillscheg ◽

Felix Berger ◽

Jonathan R Skinner ◽

...

Keyword(s):

Ejection Fraction ◽

Stroke Volume ◽

Right Ventricular ◽

Normal Values ◽

Muscle Volume ◽

Cross Sectional ◽

Interatrial Communication ◽

Systolic Volume ◽

End Diastolic Volume ◽

End Systolic Volume

AbstractCross-sectional echocardiography was performed on 108 healthy children (7 days – 17 years old) and 55 children (6 months - 16.5 years old) with interatrial communication. Right ventricular end-diastolic volume, end-systolic volume, stroke volume, ejection fraction, muscle volume, and the ratio of muscle to cavity were calculated on the basis of outlined cavity and myocardium of an apical fourchamber view.In the normal subjects right ventricular end-diastolic volume, end-systolic volume, stroke volume and muscle volume correlated with body surface area (end-diastolic volume: y=12.5x+7.8x2, r=0.99; end-systolic volume: y=4.8x+3.6x2, r=0.98; stroke volume: y=7.7x+4.2x2, r=0.98; muscle volume: y=14.1x+2.9x2, r=0.97), muscle/cavity ratio (0.85±0.17) and ejection fraction (58.9 ± 6.2%) were unrelated to body surface area. In the subjects with interatrial communication, the right ventricular volumes were significantly larger (p<0.001) than the normal values with a linear relationship to the ratio of pulmonary to systemic flows.Right ventricular volumes can be determined in normal children with acceptable repeatability using a standard apical four-chamber view. The growth related normal values provide a basis for future quantitative studies.

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Pulmonary artery hypertension in mitral stenosis: Role of right ventricular stroke volume, atrio-ventricular compliance, and pulmonary venous compliance

Journal of Anaesthesiology Clinical Pharmacology ◽

10.4103/0970-9185.94916 ◽

2012 ◽

Vol 28 (2) ◽

pp. 261 ◽

Cited By ~ 3

Author(s):

PraveenKumar Neema ◽

RameshChandra Rathod

Keyword(s):

Pulmonary Artery ◽

Stroke Volume ◽

Right Ventricular ◽

Mitral Stenosis ◽

Pulmonary Artery Hypertension ◽

Venous Compliance ◽

Ventricular Stroke Volume ◽

Ventricular Compliance ◽

Right Ventricular Stroke Volume

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Biplane ventriculography in the rat

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1986.250.1.h131 ◽

1986 ◽

Vol 250 (1) ◽

pp. H131-H136

Author(s):

J. L. Heckman ◽

L. Garvin ◽

T. Brown ◽

W. Stevenson-Smith ◽

W. P. Santamore ◽

...

Keyword(s):

Cardiac Output ◽

Left Ventricle ◽

Ejection Fraction ◽

Stroke Volume ◽

Methyl Methacrylate ◽

High Speed ◽

Water Displacement ◽

Systolic Volume ◽

End Diastolic Volume ◽

End Systolic Volume

Biplane ventriculography was performed on nine intact anesthetized rats. Images of the left ventricle large enough for analysis were obtained by placing the rats close to the radiographic tubes (direct enlargement). Sampling rates, adequate for heart rates of 500 beats/min, were obtained by filming at 500 frames/s. From the digitized silhouettes of the left ventricle the following information was obtained (means +/- SE): end-diastolic volume 0.60 +/- 0.03 ml, end-systolic volume 0.22 +/- 0.02 ml, stroke volume 0.38 +/- 0.02 ml, ejection fraction 0.63 +/- 0.02, cardiac output 118 +/- 7 ml/min, diastolic septolateral dimension 0.41 +/- 0.01 mm, diastolic anteroposterior dimension 0.40 +/- 0.01 mm, diastolic base-to-apex dimension 1.58 +/- 0.04 mm. To determine the accuracy with which the volume of the ventricle could be measured, 11 methyl methacrylate casts of the left ventricle were made. The correlation was high (r = 0.99 +/- 0.02 ml E) between the cast volumes determined by water displacement and by use of two monoplane methods (Simpson's rule of integration and the area-length method applied to the analysis of the anteroposterior films) and a biplane method (area-length). These results demonstrate that it is possible to obtain accurate dimensions and volumes of the rat left ventricle by use of high-speed ventriculography.

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The effect of left ventricle ischemia severity on cardiac performance appeared on ejection fraction using radioactive TC 99m MIBI in comparison with echocardiography

Journal of Physics Conference Series ◽

10.1088/1742-6596/2114/1/012006 ◽

2021 ◽

Vol 2114 (1) ◽

pp. 012006

Author(s):

M K Mohammed ◽

S I Essa

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Mean Value ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Systolic Volume ◽

End Diastolic Volume ◽

Significant Difference ◽

End Systolic Volume ◽

The Mean

Abstract Ischemic heart disease is a major causes of heart failure. Heart failure patients have predominantly left ventricular dysfunction (systolic or diastolic dysfunction, or both). Acute heart failure is most commonly caused by reduced myocardial contractility, and increased LV stiffness. We performed echocardiography and gated SPECT with Tc99m MIBI within 263 patients and 166 normal individuals. Left ventricular end systolic volume (LVESV), left ventricular end diastolic volume (LVEDV), and left ventricular ejection fraction (LVEF) were measured. For all degrees of ischemia, there was a significant difference between ejection fraction values measured by SPECT and echocardiography, and there were no significant differences among end systolic volume and end diastolic volume value calculated by two methods for all cases. The mean value for EDV (ECHO)/EDV (SPECT) was 1.07 ± 0.31 for degree (1, 2); in the degree 3 the mean value was 1.02 ± 0.08, and 1.005 ± 0.07 for degree 4. The mean value for ESV (ECHO)/ESV (SPECT) was 1.08 ± 0.34 for degree (1, 2); while 1.03 ± 0.12, 1.021 ± 0.128 for degree 3 and 4 respectively. This study was showed a good relation between left ventricular size and ejection fraction measured by SPECT with Tc99m, and echocardiography.

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Rapid in vivo determinations of instantaneous right ventricular pressure and volume in dogs

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1988.254.4.h622 ◽

1988 ◽

Vol 254 (4) ◽

pp. H622-H630 ◽

Cited By ~ 1

Author(s):

F. Schwiep ◽

S. S. Cassidy ◽

M. Ramanathan ◽

R. L. Johnson

Keyword(s):

Ejection Fraction ◽

Right Ventricular ◽

Systolic Volume ◽

Pentobarbital Anesthesia ◽

End Diastolic Volume ◽

End Systolic Volume ◽

Radiopaque Markers ◽

Four Levels ◽

Isovolumic Relaxation

We have developed a method for measuring in vivo canine right ventricular (RV) volume at a frequency of 60 Hz. In six dogs (17-22 kg), under pentobarbital anesthesia, 18 radiopaque markers were surgically implanted in the RV myocardium to maximally represent the RV shell. The xyz-coordinates of the markers were obtained from biplane cineradiographic recordings. RV volume was calculated from the polyhedron created by the markers by decomposing the polyhedron into 24 tetrahedrons, each of whose volumes could be solved from the xyz-coordinates of markers. RV volume was obtained each 16.7 ms, permitting detailed representation if RV volume dynamics. RV end-diastolic volume, end-systolic volume, and ejection fraction averaged 41.3 +/- 10.9, 23.0 +/- 5.8, and 0.44 +/- 0.05 ml, respectively. By simultaneously measuring RV pressure, RV pressure-volume loops were constructed that demonstrated that RV ejection occurred without significant isovolumic contraction, although isovolumic relaxation occurred at end systole. RV systolic elastance was determined in two dogs by imposing four levels of RV afterload. Maximal systolic elastance averaged 4.14 mmHg/ml under control conditions and 9.20 mmHg/ml during dobutamine infusion.

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